The relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies

Food and Chemical Toxicology

Volumn 44, Issue 4, 2006, Pages 528-537

  Amacher, David E ^a   Schomaker, Shelli J ^a   Boldt, Sherri E ^a   Mirsky, Michael ^a  

^a PFIZER INC   (United States)

Author keywords

Cytochrome P450; Liver histology; Liver hypertrophy; Microsomal enzyme induction; Monkey; Serum enzymes

Indexed keywords

4 NITROANISOLE; BETA NAPHTHOFLAVONE; CYTOCHROME P450; DEXAMETHASONE; ETHOXYRESORUFIN DEETHYLASE; ETHYLMORPHINE; ETHYLMORPHINE N DEMETHYLASE; ISONIAZID; METHOXYRESORUFIN DEETHYLASE; METHYLCELLULOSE; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; RESORUFIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; HISTOPATHOLOGY; LIVER CELL DAMAGE; LIVER TOXICITY; LIVER WEIGHT; MALE; MONKEY; NONHUMAN;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; HAPLORHINI; LIVER; MALE; MICROSOMES, LIVER; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; SPECIES SPECIFICITY; TOXICITY TESTS;

ANIMALIA; MACACA FASCICULARIS;

EID: 33644871567     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.08.027     Document Type: Article

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