Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination

Journal of Neuroscience Research

Volumn 73, Issue 4, 2003, Pages 465-470

  Rasband, Matthew N ^a,b   Kagawa, Tetsushi ^c   Park, Eunice W ^a   Ikenaka, Kazuhiro ^c   Trimmer, James S ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Demyelination; Myelin; Node of Ranvier; Oligodendrocyte; Sodium channels

Indexed keywords

PROTEOLIPID PROTEIN; SODIUM CHANNEL;

ADULT DISEASE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEMYELINATION; DISEASE COURSE; DISEASE SEVERITY; ELECTRIC POTENTIAL; IMAGE ANALYSIS; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MOUSE; MYELINATION; NERVE FIBER; NERVE FIBER MEMBRANE; NERVE INJURY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RANVIER NODE; RETINA GANGLION CELL; TRANSGENIC MOUSE; WILD TYPE;

AGING; ANIMALS; AXONS; BLOTTING, WESTERN; CELL ADHESION MOLECULES, NEURONAL; CHRONIC DISEASE; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MYELIN PROTEOLIPID PROTEIN; OPTIC NERVE; PEPTIDES; PROTEIN ISOFORMS; RANVIER'S NODES; RETINAL GANGLION CELLS; SODIUM CHANNELS;

EID: 0043123387     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10675     Document Type: Article

References (30)

1. Arroyo EJ, Xu T, Grinspan J, Lambert S, Levinson SR, Brophy PJ, Peles E, Scherer SS. 2002. Genetic dysmyelination alters the molecular architecture of the nodal region. J Neurosci 22:1726-1737.
2. Bhat MA, Rios JC, Lu Y, Garcia-Fresco GP, Ching W, St Martin M, Li J, Einheber S, Chesler M, Rosenbluth J, Salzer JL, Bellen HJ. 2001. Axonglia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 30:369-383.
3. Boiko T, Rasband MN, Levinson SR, Caldwell JH, Mandel G, Trimmer JS, Matthews G. 2001. Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron 30:91-104.
4. Boucher SE, Cypher MA, Carlock LR, Skoff RP. 2002. Proteolipid protein gene modulates viability and phenotype of neurons. J Neurosci 22:1772-1783.
5. Caldwell JH, Schaller KL, Lasher RS, Peles E, Levinson SR. 2000. Sodium channel Nav1.6 is localized at nodes of ranvier, dendrites, and synapses. Proc Natl Acad Sci USA 97:5616-5620.
6. Dugandzija-Novakovic S, Koszowski AG, Levinson SR, Shrager P. 1995. Clustering of Na+ channels and node Ranvier Formation in remyelinating axons. J Neurosci 15:492-503.
7. Dupree JL, Girault JA, Popko B. 1999. Axo-glial interactions regulate the localization of axonal paranodal proteins. J Cell Biol 147:1145-1151.
8. Einheber S, Zanazzi G, Ching W, Scherer S, Milner TA, Peles E, Salzer JL. 1997. The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination. J Cell Biol 139:1495-1506.
9. Gong B, Rhodes KJ, Bekele-Arcuri Z, Trimmler JS. 1999. Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain. J Comp Neurol 412:342-352.
10. Hinson AW, Gu XQ, Dib-Hajj S, Black JA, Waxman SG. 1997. Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro. Glia 21:339-349.
11. Inoue Y, Kagawa T, Matsumura Y, Ikenaka K, Mikoshiba K. 1996. Cell death of oligodendrocytes or demyelination induced by overexpression of proteolipid protein depending on expressed gene dosage. Neurosci Res 25:161-172.
12. Ishibashi T, Dupree JL, Ikenaka K, Hirahara Y, Honke K, Peles E, Popko B, Suzuki K, Nishino H, Baba H. 2002. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J Neurosci 22:6507-6514.
13. Jenkins SM, Bennett V. 2002. Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. Proc Natl Acad Sci USA 99:2303-2308.
14. Kagawa T, Ikenaka K, Inoue Y, Kuriyama S, Tsujii T, Nakao J, Nakajima K, Aruga J, Okano H, Mikoshiba K. 1994. Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron 13:427-442.
15. Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA. 2001. Differential control of clustering of the sodium channels Nav1.2 and Nav1.6 at developing CNS nodes of Ranvier. Neuron 30:105-119.
16. Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC. 2001. Contactin associates with Na+ channels and increases their functional expression. J Neurosci 21:7517-7525.
17. Kearney JA, Buchner DA, De Haan G, Adamska M, Levin SI, Furay AR, Albin RL, Jones JM, Montal M, Stevens MJ, Sprunger LK, Meisler MH. 2002. Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Nav1.6). Hum Mol Genet 11:2765-2775.
18. Lambert S, Davis JQ, Bennett V. 1997. Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. J Neurosci 17:7025-7036.
19. Mandel G, Cooperman SS, Maue RA, Goodman RH, Brehm P. 1988. Selective induction of brain type II Na+ channels by nerve growth factor. Proc Natl Acad Sci USA 85:924-928.
20. Menegoz M, Gaspar P, Le Bert M, Galvez T, Burgaya F, Palfrey C, Ezan P, Arnos F, Girault JA. 1997. Paranodin, a glycoprotein of neuronal paranodal membranes. Neuron 19:319-331.
21. Noebels JL, Marcom PK, Jalilian-Tehrani MH. 1991. Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. Nature 352:431-434.
22. Peles E, Nativ M, Lustig M, Grumet M, Schilling J, Martinez R, Plowman GD, Schlessinger J. 1997. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J 16:978-988.
23. Rasband MN, Peles E, Trimmer JS, Levinson SR, Lux SE, Shrager P. 1999. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci 19:7516-7528.
24. Rasband MN, Trimmer JS. 2001. Developmental clustering of ion channels at and near the node of Ranvier. Dev Biol 236:5-16.
25. Rasband MN, Trimmer JS, Schwarz TL, Levinson SR, Ellisman MH, Schachner M, Shrager P. 1998. Potassium channel distribution, clustering, and function in remyelinating rat axons. J Neurosci 18:36-47.
26. Rhodes KJ, Strassle BW, Monaghan MM, Bekele-Arcuri Z, Matos MF, Trimmer JS. 1997. Association and colocalization of the Kvβ1 and Kvβ2 beta-subunits with Kv1 alpha-subunits in manunalian brain K+ channel complexes. J Neurosci 17:8246-8258.
27. Smith MR, Smith RD, Plummer NW, Meisler MH, Goldin AL. 1998. Functional analysis of the mouse Scn8a sodium channel. J Neurosci 18:6093-6102.
28. Waxman SG. 2001. Transcriptional channelopathies: an emerging class of disorders. Nat Rev Neurosci 2:652-659.
29. Westenbroek RE, Merrick DK, Catterall WA. 1989. Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons. Neuron 3:695-704.
30. Westenbroek RE, Noebels JL, Catterall WA. 1992. Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain. J Neurosci 12:2259-2267.