Macrophage podosomes assemble at the leading lamella by growth and fragmentation

Journal of Cell Biology

Volumn 161, Issue 4, 2003, Pages 697-705

  Evans, James G ^a,b   Correia, Ivan ^b   Krasavina, Olga ^b   Watson, Nicki ^b   Matsudaira, Paul ^a,b,c  

^a BioImaging Center   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Actin; Adhesion; Fluorescence microscopy; Kymography; Microtubules

Indexed keywords

BETA ACTIN; INTEGRIN; L FIMBRIN; MEMBRANE PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL FRACTIONATION; CELL GROWTH; CELL ORGANELLE; CELL STRUCTURE; COMPLEX FORMATION; GENETIC TRANSFECTION; LAMELLAR BODY; MACROPHAGE; MICROTUBULE; MOUSE; NONHUMAN; PODOSOME; POLARIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STRATUM CORNEUM;

ACTINS; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELL POLARITY; CELL SIZE; FIBRIN; HUMANS; MACROPHAGES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROTUBULES; MODELS, BIOLOGICAL; PSEUDOPODIA; TIME FACTORS;

ANIMALIA;

EID: 0037512351     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200212037     Document Type: Article

References (32)

1. Babb, S.G., P. Matsudaira, M. Sato, I. Correia, and S.S. Lim. 1997. Fimbrin in podosomes of monocyte-derived osteoclasts. Cell Motil. Cytoskeleton. 37:308-325.
2. Beningo, K.A., M. Dembo, I. Kaverina, J.V. Small, and Y.L. Wang. 2001. Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J. Cell Biol. 153:881-888.
3. Buck, K.B., and J.Q. Zheng. 2002. Growth cone turning induced by direct local modification of microtubule dynamics. J. Neurosci. 22:9358-9367.
4. Correia, I., D. Chu, Y.H. Chou, R.D. Goldman, and P. Matsudaira. 1999. Integrating the actin and vimentin cytoskeletons, adhesion-dependent formation of fimbrin-vimentin complexes in macrophages. J. Cell Biol. 146:831-842.
5. Elbaum, M., A. Chausovsky, E.T. Levy, M. Shtutman, and A.D. Bershadsky. 1999. Microtubule involvement in regulating cell contractility and adhesion-dependent signalling: a possible mechanism for polarization of cell motility. Biochem. Soc. Symp. 65:147-172.
6. Geiger, B., and A. Bershadsky. 2001. Assembly and mechanosensory function of focal contacts. Curr. Opin. Cell Biol. 13:584-592.
7. Geiger, B., Z. Avnur, G. Rinnerthaler, H. Hinssen, and V.J. Small. 1984. Microfilament-organizing centers in areas of cell contact: cytoskeletal interactions during cell attachment and locomotion. J. Cell Biol. 99:83s-91s.
8. Izzard, C.S., and L.R. Lochner. 1976. Cell-to-substrate contacts in living fibroblasts: an interference reflexion study with an evaluation of the technique. J. Cell Sci. 21:129-159.
9. Kanehisa, J., T. Yamanaka, S. Doi, K. Turksen, J.N. Heersche, J.E. Aubin, and H. Takeuchi. 1990. A band of F-actin containing podosomes is involved in bone resorption by osteoclasts. Bone. 11:287-293.
10. Kato, T., and T. Akisaka. 1994. The cytoskeletal framework of chick osteoclasts in resin-less sections. J. Anat. 185:599-607.
11. Kaverina, I., O. Krylyshkina, and J.V. Small. 1999. Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J. Cell Biol. 146:1033-1044.
12. Lauffenburger, D.A., and A.F. Horwitz. 1996. Cell migration: a physically integrated molecular process. Cell. 84:359-369.
13. Linder, S., D. Nelson, M. Weiss, and M. Aepfelbacher. 1999. Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages. Proc. Natl. Acad. Sci. USA. 96:9648-9653.
14. Linder, S., K. Hufner, U. Wintergerst, and M. Aepfelbacher. 2000. Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages. J. Cell Sci. 113:4165-4176.
15. Marchisio, P.C., D. Cirillo, A. Teti, A. Zambonin-Zallone, and G. Tarone. 1987. Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions. Exp. Cell Res. 169:202-214.
16. Marchisio, P.C., L. Bergui, G.C. Corbascio, O. Cremona, N. D'Urso, M. Schena, L. Tesio, and F. Caligaris-Cappio. 1988. Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes. Blood. 72:830-833.
17. Mizutani, K., H. Miki, H. He, H. Maruta, and T. Takenawa. 2002. Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res. 62:669-674.
18. Ochoa, G.C., V.I. Slepnev, L. Neff, N. Ringstad, K. Takei, L. Daniell, W. Kim, H. Cao, M. McNiven, R. Baron, and P. De Camilli. 2000. A functional link between dynamin and the actin cytoskeleton at podosomes. J. Cell Biol. 150:377-389.
19. Pfaff, M., and P. Jurdic. 2001. Podosomes in osteoclast-like cells: strucrural analysis and cooperative roles of paxillin, proline-rich tyrosine kinase 2 (Pyk2) and integrin alphaVbeta3. J. Cell Sci. 114:2775-2786.
20. Reinhard, M., M. Halbrugge, U. Scheer, C. Wiegand, B.M. Jockusch, and U. Walter. 1992. The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. EMBO J. 11:2063-2070.
21. Ridley, A.J., H.F. Paterson, C.L. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70:401-410.
22. Rottner, K., A. Hall, and J.V. Small. 1999. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol. 9:640-648.
23. Smilenov, L.B., A. Mikhailov, R.J. Pelham, E.E. Marcantonio, and G.G. Gundersen. 1999. Focal adhesion motility revealed in stationary fibroblasts. Science. 286:1172-1174.
24. Svitkina, T.M., and G.G. Borisy. 1998. Correlative light and electron microscopy of the cytoskeleton of cultured cells. Methods Enzymol. 298:570-592.
25. Tanaka, E., and M.W. Kirschner. 1995. The role of microtubules in growth cone turning at substrate boundaries. J. Cell Biol. 128:127-137.
26. Tarone, G., D. Cirillo, F.G. Giancotti, P.M. Comoglio, and P.C. Marchisio. 1985. Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp. Cell Res. 159:141-157.
27. Trotter, J.A. 1981. The organization of actin in spreading macrophages. The actincytoskeleton of peritoneal macrophages is linked to the substratum via transmembrane connections. Exp. Cell Res. 132:235-248.
28. Volberg, T., B. Geiger, Z. Kam, R. Pankov, I. Simcha, H. Sabanay, J.L. Coll, E. Adamson, and A. Ben-Ze'ev. 1995. Focal adhesion formation by F9 embryonal carcinoma cells after vinculin gene disruption. J. Cell Sci. 108:2253-2260.
29. Volkman, B.F., K.E. Prehoda, J.A. Scott, F.C. Peterson, and W.A. Lim. 2002. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell. 111:565-576.
30. Waterman-Storer, C.M., R.A. Worthylake, B.P. Liu, K. Burridge, and E.D. Salmon. 1999. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat. Cell Biol. 1:45-50.
31. Zamir, E., M. Katz, Y. Posen, N. Erez, K.M. Yamada, B.Z. Katz, S. Lin, D.C. Lin, A. Bershadsky, Z. Kam, and B. Geiger. 2000. Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat. Cell Biol. 2:191-196.
32. Zhou, F.Q., C.M. Waterman-Storer, and C.S. Cohan. 2002. Focal loss of actin bundles causes microtubule redistribution and growth cone turning. J. Cell Biol. 157:839-849.