Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons

Molecular Pharmacology

Volumn 69, Issue 3, 2006, Pages 813-822

  Gu, Zhenglin ^a   Jiang, Qian ^a   Yuen, Eunice Y ^a   Yan, Zhen ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2 AMINOETHOXYDIPHENYLBORANE; 3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALPHA METHYLSEROTONIN; AMPA RECEPTOR; CARBACHOL; DOPAMINE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR 1; GLUTAMIC ACID; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PACLITAXEL; PD 168077; PROTEIN KINASE (CALCIUM,CALMODULIN) II; QUINPIROLE; SULPIRIDE; UNCLASSIFIED DRUG; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; BENZAMIDE DERIVATIVE; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; N ((4 (2 CYANOPHENYL) 1 PIPERAZINYL)METHYL) 3 METHYLBENZAMIDE; N-((4-(2-CYANOPHENYL)-1-PIPERAZINYL)METHYL)-3-METHYLBENZAMIDE; PIPERAZINE DERIVATIVE; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; CYTOSOL; DRUG INHIBITION; DRUG MECHANISM; DRUG MIXTURE; ENZYME PHOSPHORYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SYNAPTIC TRANSMISSION; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; NERVE CELL; PHOSPHORYLATION; PROTEIN TRANSPORT; SYNAPSE;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BENZAMIDES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; EXCITATORY AMINO ACID AGONISTS; NEURONS; PHOSPHORYLATION; PIPERAZINES; PREFRONTAL CORTEX; PROTEIN TRANSPORT; RATS; RECEPTORS, AMPA; RECEPTORS, DOPAMINE D4; SYNAPSES;

EID: 33644848393     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.018853     Document Type: Article

References (55)

1. Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Boles Ponto LL, and Hichwa RD (1997) Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients. Lancet 349:1730-1734.
2. Barria A, Muller D, Derkach V, Griffith LC, and Soderling TR (1997) Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science (Wash DC) 276:2042-2045.
3. Bayer KU, De Koninck P, Leonard AS, Hell JW, and Schulman H (2001) Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature (Lond) 411:801-805.
4. Braff DL and Geyer MA (1990) Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 47:181-188.
5. Braun AP and Schulman H (1995) The multifunctional calcium/calmodulin- dependent protein kinase: from form to function. Annu Rev Physiol 57:417-445.
6. Brozoski TJ, Brown RM, Rosvold HE, and Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science (Wash DC) 205:929-932.
7. 1A receptors regulate AMPA receptor channels through inhibiting CaMKII in prefrontal cortical pyramidal neurons. J Biol Chem 277:36553-36562.
8. Carlsson A, Waters N, Holm-Waters S, Tedroff J, Nilsson M, and Carlsson ML (2001) Interactions between monoamines, glutamate and GABA in schizophrenia: new evidence. Annu Rev Pharmacol Toxicol 41:237-260.
9. Chen C, Rainnie DG, Greene RW, and Tonegawa S (1994) Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science (Wash DC) 266:291-294.
10. 2+/calmodulin- kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionate type glutamate receptors. Proc Natl Acad Sci USA 96:3269-3274.
11. 2+/ calmodulin-dependent protein kinase II and a-actinin-1 in a calcium-dependent manner. J Neurosci 22:7879-7891.
12. 4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci 19:9550-9556.
13. Fong DK, Rao A, Crump FT, and Craig AM (2002) Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/ calmodulin-dependent kinase II. J Neurosci 22:2153-2164.
14. Frankland PW, O'Brien C, Ohno M, Kirkwood A, and Silva AJ (2001) Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature (Lond) 411:309-313.
15. Gardoni F, Caputi A, Cimino M, Pastorino L, Cattabeni F, and Di Luca M (1998) Calcium/ calmodulin-dependent protein kinase II is associated with NR2A/B subunits of NMDA receptor in postsynaptic densities. J Neurochem 71:1733-1741.
16. Glase SA, Akunne HC, Georgic LM, Heffner TG, MacKenzie RG, Manley PJ, Pugsley TA, and Wise LD (1997) Substituted [(4-phenylpiperazinyl)-methyl] benzamides: selective dopamine D4 agonists. J Med Chem 40:1771-1772.
17. Goldman-Rakic PS (1994) Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci 6:348-357.
18. Goldman-Rakic PS (1995) Cellular basis of working memory. Neuron 14:477-485.
19. Grace AA (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41:1-24.
20. 4 receptors in prefrontal cortex. Mol Pharmacol 66:948-955.
21. Gu Z, Zhong P, and Yan Z (2003) Activation of muscarinic receptors inhibits β-amyloid peptide -induced signaling in cortical slices. J Biol Chem 278:17546-17556.
22. Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, and Malinow R (2000) Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science (Wash DC) 287:2262-2267.
23. Hudmon A and Schulman H (2002) Neuronal CA2/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. Annu Rev Biochem 71:473-510.
24. Jentsch JD, Redmond DE Jr, Elsworth JD, Taylor JR, Youngren KD, and Roth RH (1997) Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science (Wash DC) 277:953-955.
25. Jentsch JD, Taylor JR, Redmond DE Jr, Elsworth JD, Youngren KD, and Roth RH (1999) Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology 142:78-84.
26. Kapur S and Remington G (2001) Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia. Annu Rev Med 52:503-517.
27. Kennedy MB (2000) Signal-processing machines at the postsynaptic density. Science (Wash DC) 290:750-754.
28. Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, et al. (1996) 3-((4-(4-Chlorophenyl) piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem 39:1941-1942.
29. Leonard AS, Lim IA, Hemsworth DE, Horne MC, and Hell JW (1999) Calcium/ calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA 96:3239-3244.
30. Lewis DA and Lieberman JA (2000) Catching up on schizophrenia: natural history and neurobiology. Neuron 28:325-334.
31. Malenka RC and Nicoll RA (1999) Long-term potentiation - a decade of progress? Science (Wash DC) 285:1870-1874.
32. Mammen AL, Kameyama K, Roche KW, and Huganir RL (1997) Phosphorylation of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. J Biol Chem 272:32528-32533.
33. Marie RM and Defer GL (2003) Working memory and dopamine: clinical and experimental clues. Curr Opin Neurol 16:S29-35.
34. McGhie A and Chapman J (1961) Disorders of attention and perception in early schizophrenia. Br J Med Psychol 34:102-116.
35. McGlade-McCulloh E, Yamamoto H, Tan SE, Brickey DA, and Soderling TR (1993) Phosphorylation and regulation of glutamate receptors by calcium/calmodulindependent protein kinase II. Nature (Lond) 362:640-642.
36. 2+-triggered molecular switch. Cell 44:861-870.
37. 4 receptors in GABAergic neurons of the primate brain. Nature (Lond) 381:245-248.
38. Oak JN, Oldenhof J, and Van Tol HH (2000) The dopamine D(4) receptor: one decade of research. Eur J Pharmacol 405:303-327.
39. 2+/calmodulin- dependent protein kinase binds to actin filaments in a calmodulin-sensitive manner. FEBS Lett 208:423-426.
40. 4 receptor. J Pharmacol Exp Ther 283:636-647.
41. Pawson T and Scott JD (1997) Signaling through scaffold, anchoring and adapter proteins. Science (Wash DC) 278:2075-2080.
42. 4 receptors are supersensitive to ethanol, cocaine and methamphetamine. Cell 90:991-1001.
43. Seeman P, Guan HC, and Van Tol HH (1993) Dopamine D4 receptors elevated in schizophrenia. Nature (Lond) 365:441-445.
44. Shen K and Meyer T (1999) Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Science (Wash DC) 284:162-166.
45. Shen K, Teruel MN, Subramanian K, and Meyer T (1998) CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIIalpha/beta heterooligomers to dendritic spines. Neuron 21:593-606.
46. Silva AJ, Stevens CF, Tonegawa S, and Wang Y (1992) Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (Wash DC) 257:201-206.
47. 2+/calmodulin-dependent protein kinase II. J Biol Chem 276:3719-3722.
48. Soderling TR and Derkach VA (2000) Postsynaptic protein phosphorylation and LTP. Trends Neurosci 23:75-80.
49. Strack S, McNeill RB, and Colbran RJ (2000) Mechanism and regulation of calcium/ calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 275:23798-23806.
50. Strack S and Colbran RJ (1998) Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 273:20689-20692.
51. Vallano ML, Goldenring JR, Lasher RS, and Delorenzo RJ (1986) Association of calcium/calmodulin-dependent kinase with cytoskeletal preparations: phosphorylation of tubulin, neurofilament and microtubule-associated proteins. Ann NY Acad Sci 466:357-374.
52. 4 receptor with high affinity for the antipsychotic clozapine. Nature (Lond) 350:610-614.
53. 2+/calmodulin-dependent protein kinase II and α-actinin. J Neurosci 21:423-433.
54. 4 signaling in prefrontal cortex. J Neurosci 23:9852-9861.
55. Wedzony K, Chocyk A, Mackowiak M, Fijal K, and Czyrak A (2000) Cortical localization of dopamine D4 receptors in the rat brain-immunocytochemical study. J Physiol Pharmacol 51:205-221.