Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 2, 2006, Pages

  Hinton, M ^a,b   Mellow, L ^b   Halayko, A J ^a,b   Gutsol, A ^b   Dakshinamurti, S ^a,b,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b MANITOBA INSTITUTE OF CHILD HEALTH   (Canada)

^c WS012 Women's Hospital   (Canada)

Author keywords

Persistent pulmonary hypertension of the newborn; Pulmonary hypertension; Smooth muscle

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; FURA 2 ACETOXYMETHYL ESTER; INOSITOL TRISPHOSPHATE; RYANODINE; THROMBOXANE; THROMBOXANE RECEPTOR STIMULATING AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; MACROCYCLIC COMPOUND; NIFEDIPINE; OXAZOLE DERIVATIVE; THROMBOXANE RECEPTOR; XESTOSPONGIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; HYPERSENSITIVITY; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MUSCLE CELL; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; SWINE; ANIMAL; ANOXIA; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; HEART VENTRICLE; HISTOLOGY; HUMAN; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PERSISTENT FETUS CIRCULATION; VASOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ANIMALS, NEWBORN; ANOXIA; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HEART VENTRICLES; HUMANS; INFANT, NEWBORN; MACROCYCLIC COMPOUNDS; MUSCLE CELLS; NIFEDIPINE; ORGAN SIZE; OXAZOLES; PERSISTENT FETAL CIRCULATION SYNDROME; PULMONARY ARTERY; RECEPTORS, THROMBOXANE; RYANODINE; SWINE; VASOCONSTRICTION;

EID: 33644847002     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00307.2005     Document Type: Article

References (57)

1. 2+ entry in porcine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 286: L909-L917, 2004.
2. Badesch DB, Orton EC, Zapp LM, Westcott JY, Hester J, Voelkel NF, and Stenmark KR. Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension. Am J Respir Cell Mol Biol 1: 489-498, 1989.
3. Bolla M, You D, Loufrani L, Levy BI, Levy-Toledano S, Habib A, and Henrion D. Cyclooxygenase involvement in thromboxane-dependent contraction in rat mesenteric resistance arteries. Hypertension 43: 1264-1269, 2004.
4. Bonnet S, Belus A, Hyvelin JM, Roux E, Marthan R, and Savineau JP. Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery. Am J Physiol Lung Cell Mol Physiol 281: L193-L201, 2001.
5. Bonnet S, Dubuis E, Vandier C, Martin S, Marthan R, and Savineau JP. Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing. Cardiovasc Res 53: 1019-1028, 2002.
6. + channels in the remission phase of pulmonary hypertension in chronic obstructive pulmonary diseases. Cardiovasc Res 60: 326-336, 2003.
7. + channels and pulmonary vasoconstriction: role of protein kinase Czeta. Circ Res 93: 656-663, 2003.
8. Coker RK and Laurent GJ. Pulmonary fibrosis: cytokines in the balance. Eur Respir J 11: 1218-1221, 1998.
9. Dakshinamurti S. Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn. Pediatr Pulmonol 39: 492-503, 2005.
10. Dakshinamurti S, Mellow L, and Stephens NL. Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17. Pediatr Pulmonol 4: 398-407, 2005.
11. De Beaufort AJ, Bakker AC, van Tol MJ, Poorthuis BJ, Schrama AJ, and Berger HM. Meconium is a source of pro-inflammatory substances and can induce cytokine production in cultured A549 epithelial cells. Pediatr Res 54: 491-495, 2003.
12. Dipp M, Nye PC, and Evans AM. Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle. Am J Physiol Lung Cell Mol Physiol 281: L318-L325, 2001.
13. Dogan S, Turnbaugh D, Zhang M, Cofie DQ, Fugate RD, and Kem DC. Thromboxane A2 receptor mediation of calcium and calcium transients in rat cardiomyocytes. Life Sci 60: 943-952, 1997.
14. Dorn GW II and Becker MW. Thromboxane A2 stimulated signal transduction in vascular smooth muscle. J Pharmacol Exp Ther 265: 447-456, 1993.
15. Drummond RM and Wadsworth RM. Contraction of the sheep middle cerebral, pulmonary and coronary arteries initiated by release of intracellular calcium. J Auton Pharmacol 14: 109-121, 1994.
16. Ermert M, Kuttner D, Eisenhardt N, Dierkes C, Seeger W, and Ermert L. Cyclooxygenase-2-dependent and thromboxane-dependent vascular and bronchial responses are regulated via p38 mitogen-activated protein kinase in control and endotoxin-primed rat lungs. Lab Invest 83: 333-347, 2003.
17. 2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 285: L1233-L1245, 2003.
18. Fike CD and Kaplowitz MR. Effect of chronic hypoxia on pulmonary vascular pressures in isolated lungs of newborn pigs. J Appl Physiol 77: 2853-2862, 1994.
19. Fike CD, Kaplowitz MR, and Pfister SL. Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. Am J Physiol Lung Cell Mol Physiol 284: L316-L323, 2003.
20. Fike CD, Pfister SL, Kaplowitz MR, and Madden JA. Cyclooxygenase contracting factors and altered pulmonary vascular responses in chronically hypoxic newborn pigs. J Appl Physiol 92: 67-74, 2002.
21. Fredberg JJ. Bronchospasm and its biophysical basis in airway smooth muscle. Respir Res 5: 2, 2004.
22. 2+-sensitization of smooth muscle. FEBS Lett 440: 183-187, 1998.
23. Goldman AP, Tasker RC, Haworth SG, Sigston PE, and Macrae DJ. Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics 98: 706-713, 1996.
24. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
25. Habib A, FitzGerald GA, and Maclouf J. Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets. J Biol Chem 274: 2645-2651, 1999.
26. Hall SM, Hislop AA, Wu Z, and Haworth SG. Remodelling of the pulmonary arteries during recovery from pulmonary hypertension induced by neonatal hypoxia. J Pathol 203: 575-583, 2004.
27. Hammerman C, Komar K, and Abu-Khudair H. Hypoxic vs septic pulmonary hypertension. Selective role of thromboxane mediation. Am J Dis Child 142: 319-325, 1988.
28. Hellstrand P and Nordstrom I. Cross-bridge kinetics during shortening in early and sustained contraction of intestinal smooth muscle. Am J Physiol Cell Physiol 265: C695-C703, 1993.
29. 2+ in 5-HT(1B/1D) receptor-mediated contraction of the rabbit isolated renal artery. Br J Pharmacol 130: 835-842, 2000.
30. 2+ sensitivity in rabbit pulmonary artery smooth muscle. Pflügers Arch 417: 21-28, 1990.
31. Janiak R, Wilson SM, Montague S, and Hume JR. Heterogeneity of calcium stores and elementary release events in canine pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol 280: C22-C33, 2001.
32. Jiang MJ, Chan CF, and Chang YL. Intracellular calcium and myosin light chain phosphorylation during U46619-activated vascular contraction. Life Sci 54: 2005-2013, 1994.
33. i rise in rabbit pulmonary arterial smooth muscle cells. Life Sci 70: 2321-2333, 2002.
34. Ko FN. Low-affinity thromboxane receptor mediates proliferation in cultured vascular smooth muscle cells of rats. Arterioscler Thromb Vasc Biol 17: 1274-1282, 1997.
35. 2+-free media are mediated by different signal transduction pathways in rat aorta. Br J Pharmacol 110: 875-881, 1993.
36. Lakshminrusimha S and Steinhorn RH. Pulmonary vascular biology during neonatal transition. Clin Perinatol 26: 601-619, 1999.
37. Lei Y, Zhen J, Ming XL, and Jian HK. Induction of higher expression of IL-beta and TNF-alpha, lower expression of IL-10 and cyclic guanosine monophosphate by pulmonary arterial hypertension following cardiopulmonary bypass. Asian J Surg 25: 203-208, 2002.
38. Liu F, Wu JY, Beasley D, and Orr JA. TxA2-induced pulmonary artery contraction requires extracellular calcium. Respir Physiol 109: 155-166, 1997.
39. McLeod KA, Gerlis LM, and Williams GJ. Morphology of the elastic pulmonary arteries in pulmonary hypertension: a quantitative study. Cardiol Young 9: 364-370, 1999.
40. Miyagi Y, Kobayashi S, Nishimura J, Fukui M, and Kanaide H. Resting load regulates cytosolic calcium-force relationship of the contraction of bovine cerebrovascular smooth muscle. J Physiol 484: 123-137, 1995.
41. Murray R and FitzGerald GA. Regulation of thromboxane receptor activation in human platelets. Proc Natl Acad Sci USA 86: 124-128, 1989.
42. Nakayama DK, Motoyama EK, Evans R, and Hannakan C. Relation between arterial hypoxemia and plasma eicosanoids in neonates with congenital diaphragmatic hernia. J Surg Res 53: 615-620, 1992.
43. i to hypoxia in pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol 283: L1143-L1150, 2002.
44. Parameswaran K, Janssen LJ, and O'Byrne PM. Airway hyperresponsiveness and calcium handling by smooth muscle: a "deeper look". Chest 121: 621-624, 2002.
45. Peacock AJ, Scott P, Plevin R, Wadsworth R, and Welsh D. Hypoxia enhances proliferation and generation of IP3 in pulmonary artery fibroblasts but not in those from the mesenteric circulation. Chest 114: 24S, 1998.
46. Porter VA, Reeve HL, and Cornfield DN. Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated. Am J Physiol Lung Cell Mol Physiol 279: L751-L757, 2000.
47. Reynolds PR, Mucenski ML, Le Cras TD, Nichols WC, and Whitsett JA. Midkine is regulated by hypoxia and causes pulmonary vascular remodeling. J Biol Chem 279: 37124-37132, 2004.
48. 2+ sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium dependent. Am J Physiol Lung Cell Mol Physiol 284: L1121-L1126, 2003.
49. Saetre T, Hoiby EA, Aspelin T, Lermark G, and Lyberg T. Acute serogroup A streptococcal shock: a porcine model. J Infect Dis 182: 133-141, 2000.
50. i, and ET-1-induced responses in chronically hypoxic pulmonary myocytes. Am J Physiol Lung Cell Mol Physiol 279: L884-L894, 2000.
51. Soukka H, Viinikka L, and Kaapa P. Involvement of thromboxane A2 and prostacyclin in the early pulmonary hypertension after porcine meconium aspiration. Pediatr Res 44: 838-842, 1998.
52. Takahashi N, Takeuchi K, Abe T, Sugawara A, and Abe K. Immunolocalization of rat thromboxane receptor in the kidney. Endocrinology 137: 5170-5173, 1996.
53. ++ concentration and tension in human umbilical artery. Am J Obstet Gynecol 172: 1414-1421, 1995.
54. Tozzi CA, Christiansen DL, Poiani GJ, and Riley DJ. Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility. Am J Respir Crit Care Med 149: 1317-1326, 1994.
55. Tulloh RM, Hislop AA, and Haworth SG. Role of NO in recovery from neonatal hypoxic pulmonary hypertension. Thorax 54: 796-804, 1999.
56. 2+ store and mitochondria in rat aortic smooth muscle cells. Biochem J 357: 363-371, 2001.
57. Walsh-Sukys MC, Tyson JE, Wright LL, Bauer CR, Korones SB, Stevenson DK, Verter J, Stoll BJ, Lemons JA, Papile LA, Shankaran S, Donovan EF, Oh W, Ehrenkranz RA, and Fanaroff AA. Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes. Pediatrics 105: 14-20, 2000.