Low-affinity thromboxane receptor mediates proliferation in cultured vascular smooth muscle cells of rats

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 7, 1997, Pages 1274-1282

  Ko, Feng N ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Mitogen activated protein kinase; Proliferation; Protein kinase C; Thromboxane receptor; Vascular smooth muscle cell

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITIDE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; STAUROSPORINE; THROMBOXANE; THROMBOXANE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; DNA SYNTHESIS; LIGAND BINDING; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR SMOOTH MUSCLE;

EID: 0030758513     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.7.1274     Document Type: Article

References (20)

1. Ip JH, Fuster V, Badimon L. Syndrome of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol. 1990;15:1667-1687.
2. Ross R. The pathogenesis of atherosclerosis: an update. N Engl J Med. 1986;314:488-500.
3. Olivetti G, Melissari M, Marchetti G, Anversa P. Quantitative structural changes of the rat thoracic aorta in early spontaneous hypertension: tissue composition, hypertrophy, and hyperplasia of smooth muscle cells. Circ Res. 1982;51:19-26.
4. Cutilletta AF, Benjamin M, Culpepper WS, Oparil S. Myocardial hypertrophy and ventricular performance in the absence of hypertension in spontaneously hypertensive rats. J Mol Cell Cardiol. 1978;10:689-703.
5. Uehara Y, Ishimitsu T, Kimura K, Ishii M, Ikeda T, Sugimoto T. Regulatory effects of eicosanoids on thymidine uptake by vascular smooth muscle cells of rats. Prostaglandins. 1988;36:847-857.
6. Hirata Y, Takagi Y, Fukuda Y, Marumo F. Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis. 1989;78:225-228.
7. Majack RA. Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures. J Cell Biol. 1987;105:465-471.
8. Newby AC, George SJ. Proposed roles of growth factors in mediating smooth muscle proliferation in vascular pathologies. Cardiovasc Res. 1993;27:1173-1183.
9. 2 in blood vessel walls and its physiological significance: relevance to thrombosis and hypertension. Prostaglandins Med. 1980;4:431-438.
10. 2 in Dahl genetic strain susceptible to salt-induced hypertension. Prostaglandins. 1987;33:727-738.
11. Ishimitsu T, Uehara Y, Ishii M, Ikeda T, Matsuoka H, Sugimoto T. Thromboxane and vascular smooth muscle cell growth in genetically hypertensive rats. Hypertension. 1988;12:46-51.
12. Osborne JA, Lefer AM. Cardioprotective actions of thromboxane receptor antagonist in ischemic atherosclerotic rabbits. Am J Physiol. 1988;255:H318-H324.
13. 2 receptors: evidence for different subclasses in the rat. Biochem Pharmacol. 1991;42:537-544.
14. 2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies. J Biol Chem. 1994;269:6109-6116.
15. Ko FN, Yu SM, Kang YF, Teng CM. Characterization of the thromboxane (TP-) receptor subtype involved in proliferation in cultured vascular smooth muscle cells of rat. Br J Pharmacol. 1995;116:1801-1808.
16. Ross R. The smooth muscle cell, II: growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol. 1971;50:172-186.
17. Lowry DH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
18. Alexander SPH, Kendall DA, Hill SJ. Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex. Br J Pharmacol. 1989;98:1241-1248.
19. 2+ indicators with improved fluorescence properties. J Biol Chem. 1985;260:3440-3450.
20. Tobe K, Kadowaki T, Tamemoto H, Ueki K, Hara K, Koshio O, Momomura K, Gotoh Y, Nishida E, Akamuma Y, Yazaki Y, Kasuga M. Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. J Biol Chem. 1991;266:24793-24803.