Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: A role for CPI-17

Pediatric Pulmonology

Volumn 40, Issue 5, 2005, Pages 398-407

  Dakshinamurti, S ^a,b   Mellow, L ^a   Stephens, N L ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b WS012 Women's Hospital   (Canada)

Author keywords

Hypoxia; Myosin light chain phosphatase; Pulmonary hypertension; Smooth muscle

Indexed keywords

BINDING PROTEIN; ENZYME INHIBITOR; MYOSIN LIGHT CHAIN KINASE; MYOSIN LIGHT CHAIN PHOSPHATASE; PHOSPHOPROTEIN; PROTEIN KINASE C; PROTEIN KINASE C RELATED PHOSPHATASE INHIBITOR; PROTEIN SUBUNIT; REGULATOR PROTEIN; REGULATOR PROTEIN CPI 17; THREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBSTRATE; IN VITRO STUDY; IN VIVO STUDY; LUNG ARTERY; LUNG CIRCULATION; NEONATAL CIRCULATORY TRANSITION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PULMONARY HYPERTENSION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SWINE; TISSUE HOMOGENATE; TISSUE LEVEL; UPREGULATION; VASODILATATION;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; HEART VENTRICLES; HYPERTENSION, PULMONARY; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; MYOSIN-LIGHT-CHAIN KINASE; MYOSIN-LIGHT-CHAIN PHOSPHATASE; ORGAN SIZE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PULMONARY ARTERY; SWINE; UP-REGULATION;

EID: 27544460168     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/ppul.20290     Document Type: Article

References (48)

1. Haworth SG. Development of the normal and hypertensive pulmonary vasculature. Exp Physiol 1995;80:843-853.
2. Walsh-Sukys MC, Tyson JE, Wright LL, Bauer CR, Korones SB, Stevenson DK, Verter J, Stoll BJ, Lemons JA, Papile LA, Shankaran S, Donovan EF, Oh W, Ehrenkranz RA, Fanaroff AA. Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes. Pediatrics 2000;105:14-20.
3. Finer NN, Barrington KJ. Nitric oxide for respiratory failure in infants born at or near term. Cochrane Database Syst Rev 2001; 4:CD000399.
4. Hammerman C, Komar K, Abu-Khudair H, Olsen T. Oxygen transport in newborn piglets with pulmonary hypertension. Crit Care Med 1988;16:773-778.
5. Fike CD, Kaplowitz MR. Effect of chronic hypoxia on pulmonary vascular pressures in isolated lungs of newborn pigs. J Appl Physiol 1994;77:2853-2862.
6. Belik J, Halayko AJ, Rao K, Stephens NL. Pulmonary and systemic vascular smooth muscle mechanical characteristics in newborn sheep. Am J Physiol 1992;263:881-886.
7. Tulloh RM, Hislop AA, Boels PJ, Deutsch J, Haworth SG. Chronic hypoxia inhibits postnatal maturation of porcine intrapulmonary artery relaxation. Am J Physiol 1997;272:2436-2445.
8. Gordon JB, Halla TR, Fike CD, Madden JA. Mediators of alkalosis-induced relaxation in pulmonary arteries from normoxic and chronically hypoxic piglets. Am J Physiol 1999;276:155-163.
9. Feng J, Ito M, Nishikawa M, Okinaka T, Isaka N, Hartshorne DJ, Nakano T. Dephosphorylation of distinct sites on the 20 kDa myosin light chain by smooth muscle myosin phosphatase. FEBS Lett 1999;448:101-104.
10. Kitazawa T, Somlyo AP. Desensitization and muscarinic resensitization of force and myosin light chain phosphorylation to cytoplasmic Ca2+ in smooth muscle. Biochem Biophys Res Commun 1990;172:1291-1297.
11. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol/(Lond) 2000;522:177-185.
12. Jiang H, Rao K, Liu X, Liu G, Stephens NL. Increased Ca2+ and myosin phosphorylation, but not calmodulin activity in sensitized airway smooth muscles. Am J Physiol 1995;268:739-746.
13. Liu X, Halayko AJ, Liu G, Rao K, Jiang H, Stephens NL. Myosin light chain phosphatase activity in ragweed pollen-sensitized canine tracheal smooth muscle. Am J Respir Cell Mol Biol 1994; 11:676-681.
14. Belik J, Majumdar R, Fabris VE, Kerc E, Pato MD. Myosin light chain phosphatase and kinase abnormalities in fetal sheep pulmonary hypertension. Pediatr Res 1998;43:57-61.
15. Wang Z, Lanner MC, Jin N, Swartz D, Li L, Rhoades RA. Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells: role of Rho-kinase. Am J Respir Cell Mol Biol 2003;29:465-471.
16. Smith PG, Tokui T, Ikebe M. Mechanical strain increases contractile enzyme activity in cultured airway smooth muscle cells. Am J Physiol 1995;268:999-1005.
17. Hartshorne DJ. Myosin phosphatase: subunits and interactions. Acta Physiol Scand 1998;164:483-493.
18. Muranyi A, MacDonald JA, Deng JT, Wilson DP, Haystead TA, Walsh MP, Erdodi F, Kiss E, Wu Y, Hartshorne DJ. Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. Biochem J 2002;366:211-216.
19. Borman MA, MacDonald JA, Muranyi A, Hartshorne DJ, Haystead TA. Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition. J Biol Chem 2002;277:23441-23446.
20. Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ, Nakano T. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem 1999; 274:37385-37390.
21. Velasco G, Armstrong C, Morrice N, Frame S, Cohen P. Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin. FEBS Lett 2002;527:101-104.
22. Hayashi Y, Senba S, Yazawa M, Brautigan DL, Eto M. Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa. J Biol Chem 2001;276:39858-39863.
23. Deng JT, Sutherland C, Brautigan DL, Eto M, Walsh MP. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Biochem J 2002;367:517-524.
24. Takizawa N, Koga Y, Ikebe M. Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase. Biochem Biophys Res Commun 2002;297:773-778.
25. MacDonald JA, Eto M, Borman MA, Brautigan DL, Haystead TA. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. FEBS Lett 2001;493:91-94.
26. Eto M, Kitazawa T, Yazawa M, Mukai H, Ono Y, Brautigan DL. Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. J Biol Chem 2001;276:29072-29078.
27. Niiro N, Koga Y, Ikebe M. Agonist-induced changes in the phosphorylation of the myosin-binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle. Biochem J 2003; 369:117-128.
28. Fike CD, Pfister SL, Kaplowitz MR, Madden JA. Cyclooxygenase contracting factors and altered pulmonary vascular responses in chronically hypoxic newborn pigs. J Appl Physiol 2002;92: 67-74.
29. Arrigoni FI, Vallance P, Haworth SG, Leiper JM. Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation 2003;107:1195-1201.
30. Shime N, Hashimoto S, Hiramatsu N, Oka T, Kageyama K, Tanaka Y. Hypoxic gas therapy using nitrogen in the preoperative management of neonates with hypoplastic left heart syndrome. Pediatr Crit Care Med 2000;1:38-41.
31. Haworth SG, Hislop AA. Effect of hypoxia on adaptation of the pulmonary circulation to extra-uterine life in the pig. Cardiovasc Res 1982;16:293-303.
32. Etter EF, Eto M, Wardle RL, Brautigan DL, Murphy RA. Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation. J Biol Chem 2001; 276:34681-34685.
33. Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, Nakano T. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 2003;92:411-418.
34. Pato MD, Adelstein RS. Characterization of a Mg2+-dependent phosphatase from turkey gizzard smooth muscle. J Biol Chem 1983;258:7055-7058.
35. Pato MD, Tulloch AG, Walsh MP, Kerc E. Smooth muscle phosphatases: structure, regulation, and function. Can J Physiol Pharmacol 1994;72:1427-1433.
36. Fike CD, Kaplowitz MR. Longitudinal distribution of pulmonary vascular pressures as a function of postnatal age in rabbits. J Appl Physiol 1991;71:2160-2167.
37. Goldman AP, Tasker RC, Haworth SG, Sigston PE, Macrae DJ. Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics 1996;98: 706-713.
38. Ishihara H, Martin BL, Brautigan DL, Karaki H, Ozaki H, Kato Y, Fusetani N, Watabe S, Hashimoto K, Uemura D, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun 1989;159:871-877.
39. Takai A, Troschka M, Mieskes G, Somlyo AV. Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2. Biochem J 1989;262: 617-623.
40. Gong MC, Cohen P, Kitazawa T, Ikebe M, Masuo M, Somlyo AP, Somlyo AV. Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle. J Biol Chem 1992;267:14662-14668.
41. Mitsui T, Inagaki M, Ikebe M. Purification and characterization of smooth muscle myosin-associated phosphatase from chicken gizzards. J Biol Chem 1992;267:16727-16735.
42. Chu Y, Wilson SE, Schlender KK. A latent form of protein phosphatase 1 alpha associated with bovine heart myofibrils. Biochim Biophys Acta 1994;1208:45-54.
43. Wang Z, Jin N, Ganguli S, Swartz DR, Li L, Rhoades RA. Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction. Am J Respir Cell Mol Biol 2001;25:628-635.
44. Bailly K, Ridley AJ, Hall SM, Haworth SG. RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific. Circ Res 2004;94:1383-1391.
45. Kitazawa T, Takizawa N, Ikebe M, Eto M. Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle. J Physiol/ (Lond) 1999;520:139-152.
46. Kitazawa T, Eto M, Woodsome TP, Khalequzzaman M. Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca(2+) sensitization in rabbit smooth muscle. J Physiol/(Lond) 2003;546:879-889.
47. Woodsome TP, Eto M, Everett A, Brautigan DL, Kitazawa T. Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. J Physiol/(Lond) 2001;535:553-564.
48. Takizawa N, Niiro N, Ikebe M. Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17. FEBS Lett 2002;515:127-132.