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Volumn 6, Issue 2, 2006, Pages 157-165

Inherited disposition to cardiac myxoma development

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN;

EID: 33644846508     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1798     Document Type: Review
Times cited : (31)

References (109)
  • 1
    • 21344457592 scopus 로고
    • Epileptiform attacks due to myxoma of the right auricle
    • Kendall, D. & Symonds, B. Epileptiform attacks due to myxoma of the right auricle. Br. Heart J. 14, 139-143 (1952).
    • (1952) Br. Heart J. , vol.14 , pp. 139-143
    • Kendall, D.1    Symonds, B.2
  • 3
    • 0018928973 scopus 로고
    • A syndrome of various cutaneous pigmented lesions, myxoid neurofibromata and atrial myxoma: The NAME syndrome
    • Atherton, D. J., Pitcher, D. W., Wells, R. S. & MacDonald, D. M. A syndrome of various cutaneous pigmented lesions, myxoid neurofibromata and atrial myxoma: the NAME syndrome. Br. J. Dermatol. 103, 421-429 (1980).
    • (1980) Br. J. Dermatol. , vol.103 , pp. 421-429
    • Atherton, D.J.1    Pitcher, D.W.2    Wells, R.S.3    MacDonald, D.M.4
  • 4
    • 0015876146 scopus 로고
    • Lentiginosis and left atrial myxoma
    • Rees, J. R., Ross, F. G. M. & Keen, G. Lentiginosis and left atrial myxoma. Brit Heart J. 35, 874-876 (1973).
    • (1973) Brit Heart J. , vol.35 , pp. 874-876
    • Rees, J.R.1    Ross, F.G.M.2    Keen, G.3
  • 5
    • 0026092853 scopus 로고
    • Autosomal dominant transmission of the NAME syndrome (nevi, atrial myxoma, mucinosis of the skin and endocrine overactivity)
    • Koopman, R. J. & Happle, R. Autosomal dominant transmission of the NAME syndrome (nevi, atrial myxoma, mucinosis of the skin and endocrine overactivity). Hum. Genet. 86, 300-304 (1991).
    • (1991) Hum. Genet. , vol.86 , pp. 300-304
    • Koopman, R.J.1    Happle, R.2
  • 6
    • 0022397926 scopus 로고
    • The complex of myxomas, spotty pigmentation, and endocrine overactivity
    • Carney, J. A., Gordon, H., Carpenter, P. C., Shenoy, B. V. & Go, V. L. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine 64, 270-283 (1985). Elegant clinical description of the syndrome that bears the eponym Carney complex.
    • (1985) Medicine , vol.64 , pp. 270-283
    • Carney, J.A.1    Gordon, H.2    Carpenter, P.C.3    Shenoy, B.V.4    Go, V.L.5
  • 7
    • 0023092343 scopus 로고
    • 'Syndrome myxoma': A subset of patients with cardiac myxoma associated with pigmented skin lesions and peripheral and endocrine neoplasms
    • Vidaillet, H. J. Jr, Seward, J. B., Fyke, F. E. 3rd, Su, W. P. & Tajik, A. J. 'Syndrome myxoma': a subset of patients with cardiac myxoma associated with pigmented skin lesions and peripheral and endocrine neoplasms. Br. Heart J. 57, 247-255 (1987).
    • (1987) Br. Heart J. , vol.57 , pp. 247-255
    • Vidaillet Jr., H.J.1    Seward, J.B.2    Fyke III, F.E.3    Su, W.P.4    Tajik, A.J.5
  • 8
    • 4644277913 scopus 로고    scopus 로고
    • Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice
    • Veugelers, M. et al. Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proc. Natl Acad. Sci. USA 101, 14222-14227 (2004). Comprehensive survey of PRKAR1A mutations in CNC and description of the histological, biochemical and genetic features of a genetically engineered mouse model of CNC.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 14222-14227
    • Veugelers, M.1
  • 9
    • 3342914030 scopus 로고    scopus 로고
    • Mutation of perinatal myosin heavy chain associated with a Carney complex variant
    • Veugelers, M. et al. Mutation of perinatal myosin heavy chain associated with a Carney complex variant. N. Engl. J. Med. 351, 460-469 (2004). Describes the identification of a gene that is responsible for trismus-pseudocamptodactyly syndrome and a variant form of CNC that includes trismus-pseudocamptodactyly.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 460-469
    • Veugelers, M.1
  • 12
    • 0029643775 scopus 로고
    • Cardiac myxomas
    • Reynen, K. Cardiac myxomas. N. Engl. J. Med. 333, 1610-1617 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1610-1617
    • Reynen, K.1
  • 13
    • 0015596534 scopus 로고
    • Structural features of cardiac myxomas: Histology, histchemistry and electron microscopy
    • Ferrans, V. J. & Roberts, W. C. Structural features of cardiac myxomas: histology, histchemistry and electron microscopy. Hum. Pathol. 4, 111-146 (1973).
    • (1973) Hum. Pathol. , vol.4 , pp. 111-146
    • Ferrans, V.J.1    Roberts, W.C.2
  • 14
    • 0024373684 scopus 로고
    • The identity and histogenesis of cardiac myxomas: A controversy put to rest
    • Lie, J. T. The identity and histogenesis of cardiac myxomas: a controversy put to rest. Arch. Pathol. Lab. 113, 724-726 (1989).
    • (1989) Arch. Pathol. Lab. , vol.113 , pp. 724-726
    • Lie, J.T.1
  • 15
    • 0037061884 scopus 로고    scopus 로고
    • A 27-year-old woman with two intracardiac masses and a history of endocrinopathy
    • Basson, C. T. & Aretz, H. T. A 27-year-old woman with two intracardiac masses and a history of endocrinopathy. N. Engl. J. Med. 346, 1152-1158 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1152-1158
    • Basson, C.T.1    Aretz, H.T.2
  • 16
    • 0022633003 scopus 로고
    • The significance of multiple, recurrent, and 'complex' cardiac myxomas
    • McCarthy, P. M. et al. The significance of multiple, recurrent, and 'complex' cardiac myxomas. J. Thorac. Cardiovasc. Surg. 91, 389-396 (1986).
    • (1986) J. Thorac. Cardiovasc. Surg. , vol.91 , pp. 389-396
    • McCarthy, P.M.1
  • 17
    • 0034853288 scopus 로고    scopus 로고
    • Clinical and molecular features of the Carney complex: Diagnostic criteria and recommendations for patient evaluation
    • Stratakis, C. A., Kirschner, L. S. & Carney, J. A. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J. Clin. Endocrinol. Metab. 86, 4041-4046 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4041-4046
    • Stratakis, C.A.1    Kirschner, L.S.2    Carney, J.A.3
  • 18
    • 85047691288 scopus 로고
    • Cutaneous myxomas. A major component of the complex of myxomas, spotty pigmentation, and endocrine overactivity
    • Carney, J. A., Headington, J. T. & Su, W. P. Cutaneous myxomas. A major component of the complex of myxomas, spotty pigmentation, and endocrine overactivity. Arch. Dermatol. 122, 790-798 (1986).
    • (1986) Arch. Dermatol. , vol.122 , pp. 790-798
    • Carney, J.A.1    Headington, J.T.2    Su, W.P.3
  • 19
    • 23044468132 scopus 로고    scopus 로고
    • The Carney complex: Unusual skin findings and recurrent cardiac myxoma
    • Bennett, K. R. et al. The Carney complex: unusual skin findings and recurrent cardiac myxoma. Arch. Dermatol. 141, 916-918 (2005).
    • (2005) Arch. Dermatol. , vol.141 , pp. 916-918
    • Bennett, K.R.1
  • 20
    • 0023226653 scopus 로고
    • Ocular pigmented spots and eyelid myxomas
    • Kennedy, R. H., Waller, R. R. & Carney, J. A. Ocular pigmented spots and eyelid myxomas. Am. J. Ophthal. 104, 533-538 (1987).
    • (1987) Am. J. Ophthal. , vol.104 , pp. 533-538
    • Kennedy, R.H.1    Waller, R.R.2    Carney, J.A.3
  • 21
    • 0019959530 scopus 로고
    • Primary adrenocortical nodular dysplasia with Cushing's syndrome and cardiac myxomas: A peculiar familial disease
    • Schweizer-Cagianut, M., Salomon, F. & Hedinger, C. E. Primary adrenocortical nodular dysplasia with Cushing's syndrome and cardiac myxomas: a peculiar familial disease. Virchows. Arch. Path. Anat. 397, 183-192 (1982).
    • (1982) Virchows. Arch. Path. Anat. , vol.397 , pp. 183-192
    • Schweizer-Cagianut, M.1    Salomon, F.2    Hedinger, C.E.3
  • 22
    • 12244284607 scopus 로고    scopus 로고
    • Pituitary adenoma in Carney complex: An immunohistochemical, ultrastructural, and immunoelectron microscopic study
    • Kurtkaya-Yapicier, O. et al. Pituitary adenoma in Carney complex: an immunohistochemical, ultrastructural, and immunoelectron microscopic study. Ultrastruct. Pathol. 26, 345-353 (2002).
    • (2002) Ultrastruct. Pathol. , vol.26 , pp. 345-353
    • Kurtkaya-Yapicier, O.1
  • 23
    • 0030835716 scopus 로고    scopus 로고
    • Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex)
    • Stratakis, C. A. et al. Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex) J. Clin. Endocrinol. Metab. 82, 2037-2043 (1997).
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 2037-2043
    • Stratakis, C.A.1
  • 24
    • 0029129214 scopus 로고
    • Carney complex: Report of three cases
    • Radin, R. & Kempf, R. A. Carney complex: report of three cases. Radiology 196, 383-386 (1995).
    • (1995) Radiology , vol.196 , pp. 383-386
    • Radin, R.1    Kempf, R.A.2
  • 26
    • 0027393813 scopus 로고
    • Psammomatous melanotic schwannoma: A new cutaneous marker for Carney's complex
    • Utiger, C. A. & Headington, J. T. Psammomatous melanotic schwannoma: a new cutaneous marker for Carney's complex. Arch. Dermatol. 129, 202-204 (1993).
    • (1993) Arch. Dermatol. , vol.129 , pp. 202-204
    • Utiger, C.A.1    Headington, J.T.2
  • 27
    • 0344011545 scopus 로고    scopus 로고
    • Cutaneous psammomatous melanotic schwannoma: Non-recurrence with surgical excision
    • Claessens, N. et al. Cutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision. Am. J. Clin. Dermatol. 4, 799-802 (2003).
    • (2003) Am. J. Clin. Dermatol. , vol.4 , pp. 799-802
    • Claessens, N.1
  • 28
    • 0025783744 scopus 로고
    • Myxoid fibroadenoma and allied conditions (myxomatosis) of the breast. A heritable disorder with special associations including cardiac and cutaneous myxomas
    • Carney, J. A. & Toorkey, B. C. Myxoid fibroadenoma and allied conditions (myxomatosis) of the breast. A heritable disorder with special associations including cardiac and cutaneous myxomas. Am. J. Surg. Pathol. 15, 713-721 (1991).
    • (1991) Am. J. Surg. Pathol. , vol.15 , pp. 713-721
    • Carney, J.A.1    Toorkey, B.C.2
  • 29
    • 0025899534 scopus 로고
    • Ductal adenoma of the breast with tubular features. a probable component of the complex of myxomas, spotty pigmentation, endocrine overactivity, and schwannomas
    • Carney, J. A. & Toorkey, B. C. Ductal adenoma of the breast with tubular features. A probable component of the complex of myxomas, spotty pigmentation, endocrine overactivity, and schwannomas. Am. J. Surg. Pathol. 15, 722-731 (1991).
    • (1991) Am. J. Surg. Pathol. , vol.15 , pp. 722-731
    • Carney, J.A.1    Toorkey, B.C.2
  • 30
    • 0034534363 scopus 로고    scopus 로고
    • Ovarian lesions in Carney complex: Clinical genetics and possible predisposition to malignancy
    • Stratakis, C. A. et al. Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy. J. Clin. Endocrinol. Metab. 85, 4359-4366 (2000).
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 4359-4366
    • Stratakis, C.A.1
  • 31
    • 0020790041 scopus 로고
    • Myxoid tumor of the uterus and right atrial myxomas
    • Barlow, J. F. et al. Myxoid tumor of the uterus and right atrial myxomas. S. D. J. Med. 36, 9-13 (1983).
    • (1983) S. D. J. Med. , vol.36 , pp. 9-13
    • Barlow, J.F.1
  • 32
    • 0030049026 scopus 로고    scopus 로고
    • Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2
    • Stratakis, C. A. et al. Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. J. Clin. Invest. 97, 699-705 (1996). Survey of clinical features of CNC and a potential CNC locus on chromosome 2, although several families that were subsequently described were shown to be associated with PRKAR1A defects on chromosome 17 (see references 33-35).
    • (1996) J. Clin. Invest. , vol.97 , pp. 699-705
    • Stratakis, C.A.1
  • 33
    • 0032497947 scopus 로고    scopus 로고
    • Identification of a novel genetic locus for familial cardiac myxomas and Carney complex
    • Casey, M. et al. Identification of a novel genetic locus for familial cardiac myxomas and Carney complex. Circulation 98, 2560-2566 (1998). Demonstration that the most important gene defect that causes CNC is associated with chromosome 17.
    • (1998) Circulation , vol.98 , pp. 2560-2566
    • Casey, M.1
  • 34
    • 18544406892 scopus 로고    scopus 로고
    • Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex
    • Casey, M. et al. Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex. J. Clin. Invest. 106, R31-R38 (2000). Initial published report that mutations in the PRKAR1A gene cause CNC.
    • (2000) J. Clin. Invest. , vol.106
    • Casey, M.1
  • 35
    • 0033812849 scopus 로고    scopus 로고
    • Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex
    • Kirschner, L. S. et al. Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex. Nature Genet. 26, 89-92 (2000). Identification of mutations in the PRKAR1A gene that cause CNC.
    • (2000) Nature Genet. , vol.26 , pp. 89-92
    • Kirschner, L.S.1
  • 36
    • 0025940335 scopus 로고
    • The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase
    • Boshart, M., Weih, F., Nichols, M. & Schutz, G. The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell 66, 849-859 (1991).
    • (1991) Cell , vol.66 , pp. 849-859
    • Boshart, M.1    Weih, F.2    Nichols, M.3    Schutz, G.4
  • 37
    • 0025944522 scopus 로고
    • Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A
    • Jones, K. W., Shapero, M. H., Chevrette, M. & Fournier, R. E. Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A. Cell 66, 861-872 (1991).
    • (1991) Cell , vol.66 , pp. 861-872
    • Jones, K.W.1    Shapero, M.H.2    Chevrette, M.3    Fournier, R.E.4
  • 38
    • 0024218550 scopus 로고
    • Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches
    • McKnight, G. S. et al. Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches. Recent Prog. Horm. Res. 44, 307-335 (1988).
    • (1988) Recent Prog. Horm. Res. , vol.44 , pp. 307-335
    • McKnight, G.S.1
  • 39
    • 0021280745 scopus 로고
    • Rat adipose tissue cAMP-dependent protein kinase: A unique form of type II
    • Beebe, S. J. & Corbin, J. D. Rat adipose tissue cAMP-dependent protein kinase: a unique form of type II. Mol. Cell. Endocrinol. 36, 67-78 (1984).
    • (1984) Mol. Cell. Endocrinol. , vol.36 , pp. 67-78
    • Beebe, S.J.1    Corbin, J.D.2
  • 40
    • 0025810398 scopus 로고
    • Cyclic nucleotide-dependent protein kinases
    • Scott, J. D. Cyclic nucleotide-dependent protein kinases. Pharmacol. Ther. 50, 123-145 (1991).
    • (1991) Pharmacol. Ther. , vol.50 , pp. 123-145
    • Scott, J.D.1
  • 41
    • 0025330489 scopus 로고
    • cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes
    • Taylor, S. S., Buechler, J. A. & Yonemoto, W. cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Ann. Rev. Biochem. 59, 971-1005 (1990). Review of PKA structure and function.
    • (1990) Ann. Rev. Biochem. , vol.59 , pp. 971-1005
    • Taylor, S.S.1    Buechler, J.A.2    Yonemoto, W.3
  • 42
    • 0034642302 scopus 로고    scopus 로고
    • Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex
    • Kirschner, L. S. et al. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex. Hum. Mol. Genet. 9, 3037-3046 (2000). Survey of PRKAR1A mutations in CNC and illustration of NMD of mutant alleles.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 3037-3046
    • Kirschner, L.S.1
  • 43
    • 0030920219 scopus 로고    scopus 로고
    • Interaction of the regulatory and catalytic subunits of the cAMP-dependent protein kinase. Electrostatic sites on the type Iα regulatory subunit
    • Gibson, R. M., Ji-Buechler, Y. & Taylor, S. S. Interaction of the regulatory and catalytic subunits of the cAMP-dependent protein kinase. Electrostatic sites on the type Iα regulatory subunit. J. Biol. Chem. 272, 16343-16350 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 16343-16350
    • Gibson, R.M.1    Ji-Buechler, Y.2    Taylor, S.S.3
  • 44
    • 0031463936 scopus 로고    scopus 로고
    • Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit
    • Gibson, R. M. & Taylor, S. S. Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit. J. Biol. Chem. 272, 31998-32005 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 31998-32005
    • Gibson, R.M.1    Taylor, S.S.2
  • 45
    • 0036907704 scopus 로고    scopus 로고
    • Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: Augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD
    • Groussin, L. et al. Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. Am. J. Hum. Genet. 71, 1433-1442 (2002).
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1433-1442
    • Groussin, L.1
  • 47
    • 0032837376 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in health and disease
    • Frischmeyer, P. A. & Dietz, H. C. Nonsense-mediated mRNA decay in health and disease. Hum. Mol. Genet. 8, 1893-1900 (1999).
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1893-1900
    • Frischmeyer, P.A.1    Dietz, H.C.2
  • 48
    • 20744431604 scopus 로고    scopus 로고
    • PRKAR1A gene mutation in patients with cardiac myxoma
    • Mabuchi, T. et al. PRKAR1A gene mutation in patients with cardiac myxoma. Int. J. Cardiol. 102, 273-277 (2005).
    • (2005) Int. J. Cardiol. , vol.102 , pp. 273-277
    • Mabuchi, T.1
  • 49
    • 0036291278 scopus 로고    scopus 로고
    • Mutations of the gene encoding the protein kinase A type I-α regulatory subunit (PRKAR1A) in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas' (Carney complex)
    • Stratakis, C. A. Mutations of the gene encoding the protein kinase A type I-α regulatory subunit (PRKAR1A) in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas' (Carney complex). Ann. NY Acad. Sci. 968, 3-21 (2002).
    • (2002) Ann. NY Acad. Sci. , vol.968 , pp. 3-21
    • Stratakis, C.A.1
  • 50
    • 0032428008 scopus 로고    scopus 로고
    • Characterization of the adrenal gland pathology of Carney complex, and molecular genetics of the disease
    • Taymans, S. E., Kirschner, L. S., Giatzakis, C. & Stratakis, C. A. Characterization of the adrenal gland pathology of Carney complex, and molecular genetics of the disease. Endocr. Res. 24, 863-864 (1998).
    • (1998) Endocr. Res. , vol.24 , pp. 863-864
    • Taymans, S.E.1    Kirschner, L.S.2    Giatzakis, C.3    Stratakis, C.A.4
  • 51
    • 0031690215 scopus 로고    scopus 로고
    • Evidence for a second genetic locus in Carney complex
    • Irvine, A. D. et al. Evidence for a second genetic locus in Carney complex. Br. J. Dermatol. 139, 572-576 (1998).
    • (1998) Br. J. Dermatol. , vol.139 , pp. 572-576
    • Irvine, A.D.1
  • 52
    • 0023714421 scopus 로고
    • A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit Cα
    • Maldonado, F. & Hanks, S. K. A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit Cα. Nucleic Acids Res. 16, 8189-8190 (1988).
    • (1988) Nucleic Acids Res. , vol.16 , pp. 8189-8190
    • Maldonado, F.1    Hanks, S.K.2
  • 53
    • 0025343605 scopus 로고
    • Molecular cloning of a tissue-specific protein kinase (Cγ) from human testis - Representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase
    • Beebe, S. J. et al. Molecular cloning of a tissue-specific protein kinase (Cγ) from human testis - representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol. Endocrinol. 4, 465-475 (1990).
    • (1990) Mol. Endocrinol. , vol.4 , pp. 465-475
    • Beebe, S.J.1
  • 54
    • 0030587442 scopus 로고    scopus 로고
    • The gene encoding the catalytic subunit C-α of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1
    • Tasken, K. et al. The gene encoding the catalytic subunit C-α of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. Genomics 36, 535-538 (1996).
    • (1996) Genomics , vol.36 , pp. 535-538
    • Tasken, K.1
  • 55
    • 84915472581 scopus 로고
    • Assignment of the gene encoding the catalytic subunit Cβ of cAMP-dependent protein kinase to the p36 band on chromosome 1
    • Berube, D. et al. Assignment of the gene encoding the catalytic subunit Cβ of cAMP-dependent protein kinase to the p36 band on chromosome 1. Cytogenet. Cell. Genet. 58, 1850 (1991).
    • (1991) Cytogenet. Cell. Genet. , vol.58 , pp. 1850
    • Berube, D.1
  • 56
    • 0025940335 scopus 로고
    • The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase
    • Boshart, M., Weih, F., Nichols, M. & Schutz, G. The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell 66, 849-859 (1991).
    • (1991) Cell , vol.66 , pp. 849-859
    • Boshart, M.1    Weih, F.2    Nichols, M.3    Schutz, G.4
  • 57
    • 0032526464 scopus 로고    scopus 로고
    • Mapping of the gene encoding the regulatory subunit RII-α of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2
    • Tasken, K., Naylor, S. L., Solberg, R. & Jahnsen, T. Mapping of the gene encoding the regulatory subunit RII-α of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2. Genomics 50, 378-381 (1998).
    • (1998) Genomics , vol.50 , pp. 378-381
    • Tasken, K.1    Naylor, S.L.2    Solberg, R.3    Jahnsen, T.4
  • 58
    • 0026661540 scopus 로고
    • Mapping of the regulatory subunits RI-β and RII-β of cAMP-dependent protein kinase genes on human chromosome 7
    • Solberg, R. et al. Mapping of the regulatory subunits RI-β and RII-β of cAMP-dependent protein kinase genes on human chromosome 7. Genomics 14, 63-69 (1992).
    • (1992) Genomics , vol.14 , pp. 63-69
    • Solberg, R.1
  • 59
    • 0034241380 scopus 로고    scopus 로고
    • Specificity in the cAMP-PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA
    • Skalhegg, B. S. & Tasken, K. Specificity in the cAMP-PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Front. Biosci. 5, D678-D693 (2000).
    • (2000) Front. Biosci. , vol.5
    • Skalhegg, B.S.1    Tasken, K.2
  • 60
    • 0016430836 scopus 로고
    • The distribution and dissociation of cyclic adenosine 3′:5′-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues
    • Corbin, J. D., Keely, S. L. & Park, C. R. The distribution and dissociation of cyclic adenosine 3′:5′-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J. Biol. Chem. 250, 218-225 (1975).
    • (1975) J. Biol. Chem. , vol.250 , pp. 218-225
    • Corbin, J.D.1    Keely, S.L.2    Park, C.R.3
  • 61
    • 0011564219 scopus 로고
    • Genetic characterization of a brainspecific form of the type I regulatory subunit of cAMP-dependent protein kinase
    • Clegg, C. H., Cadd, G. G. & McKnight, G. S. Genetic characterization of a brainspecific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc. Natl Acad. Sci. USA 85, 3703-3707 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 3703-3707
    • Clegg, C.H.1    Cadd, G.G.2    McKnight, G.S.3
  • 62
    • 10044253425 scopus 로고    scopus 로고
    • AKAP signalling complexes: Focal points in space and time
    • Wong, W. & Scott, J. D. AKAP signalling complexes: focal points in space and time. Nature Rev. Mol. Cell Biol. 5, 959-970 (2004).
    • (2004) Nature Rev. Mol. Cell Biol. , vol.5 , pp. 959-970
    • Wong, W.1    Scott, J.D.2
  • 63
    • 0035957525 scopus 로고    scopus 로고
    • The biological functions of A-kinase anchor proteins
    • Feliciello, A., Gottesman, M. E. & Awedimento, E. V. The biological functions of A-kinase anchor proteins. J. Mol. Biol. 308, 99-114 (2001).
    • (2001) J. Mol. Biol. , vol.308 , pp. 99-114
    • Feliciello, A.1    Gottesman, M.E.2    Awedimento, E.V.3
  • 64
    • 0028588997 scopus 로고
    • A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP
    • Rubin, C. S. A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. Biochim. Biophys. Acta. 1224, 467-479 (1994).
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 467-479
    • Rubin, C.S.1
  • 65
    • 0035298062 scopus 로고    scopus 로고
    • Type I protein kinase a is localized to interphase microtubules and strongly associated with the mitotic spindle
    • Imaizumi-Scherrer, T., Faust, D. M., Barradeau, S., Hellio, R. & Weiss, M. C. Type I protein kinase a is localized to interphase microtubules and strongly associated with the mitotic spindle. Exp. Cell Res. 264, 250-265 (2001).
    • (2001) Exp. Cell Res. , vol.264 , pp. 250-265
    • Imaizumi-Scherrer, T.1    Faust, D.M.2    Barradeau, S.3    Hellio, R.4    Weiss, M.C.5
  • 66
    • 0027730774 scopus 로고
    • A-kinase anchoring proteins: A key to selective activation of cAMP-responsive events?
    • Coghlan, V. M., Bergeson, S. E., Langeberg, L., Nilaver, G. & Scott, J. D. A-kinase anchoring proteins: a key to selective activation of cAMP-responsive events? Mol. Cell. Biochem. 127-128, 309-319 (1993).
    • (1993) Mol. Cell. Biochem. , vol.127-128 , pp. 309-319
    • Coghlan, V.M.1    Bergeson, S.E.2    Langeberg, L.3    Nilaver, G.4    Scott, J.D.5
  • 67
    • 0028810676 scopus 로고
    • Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells
    • Lin, R. Y., Moss, S. B. & Rubin, C. S. Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. J. Biol. Chem. 270, 27804-27811 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 27804-27811
    • Lin, R.Y.1    Moss, S.B.2    Rubin, C.S.3
  • 68
    • 0030570773 scopus 로고    scopus 로고
    • Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain
    • Trendelenburg, G., Hummel, M., Riecken, E. O. & Hanski, C. Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. Biochem. Biophys. Res. Commun. 225, 313-319 (1996).
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 313-319
    • Trendelenburg, G.1    Hummel, M.2    Riecken, E.O.3    Hanski, C.4
  • 69
    • 0030881687 scopus 로고    scopus 로고
    • D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
    • Huang, L. J., Durick, K., Weiner, J. A., Chun, J. & Taylor, S. S. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc. Natl Acad. Sci. USA 94, 11184-11189 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 11184-11189
    • Huang, L.J.1    Durick, K.2    Weiner, J.A.3    Chun, J.4    Taylor, S.S.5
  • 70
    • 0035853041 scopus 로고    scopus 로고
    • Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein
    • Wang, L. et al. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc. Natl Acad. Sci. USA 98, 3220-3225 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3220-3225
    • Wang, L.1
  • 72
    • 0035789886 scopus 로고    scopus 로고
    • PKA, PKC, and AKAP localization in and around the neuromuscular junction
    • Perkins, G. A. et al. PKA, PKC, and AKAP localization in and around the neuromuscular junction. BMC Neurosci. 2, 17 (2001).
    • (2001) BMC Neurosci. , vol.2 , pp. 17
    • Perkins, G.A.1
  • 73
    • 0030625680 scopus 로고    scopus 로고
    • Anchoring and scaffold proteins for kinases and phosphatases
    • Lester, L. B. & Scott, J. D. Anchoring and scaffold proteins for kinases and phosphatases. Recent. Prog. Horm. Res. 52, 409-429 (1997).
    • (1997) Recent. Prog. Horm. Res. , vol.52 , pp. 409-429
    • Lester, L.B.1    Scott, J.D.2
  • 74
    • 0035968196 scopus 로고    scopus 로고
    • The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the β2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization
    • Fan, G., Shumay, E., Wang, H. & Malbon, C. C. The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the β2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization. J. Biol. Chem. 276, 24005-24014 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 24005-24014
    • Fan, G.1    Shumay, E.2    Wang, H.3    Malbon, C.C.4
  • 75
    • 0036008839 scopus 로고    scopus 로고
    • Mutation of the Cα subunit of PKA leads to growth retardation and sperm dysfunction
    • Skalhegg, B. S. et al. Mutation of the Cα subunit of PKA leads to growth retardation and sperm dysfunction. Mol. Endocrinol. 16, 630-639 (2002).
    • (2002) Mol. Endocrinol. , vol.16 , pp. 630-639
    • Skalhegg, B.S.1
  • 76
    • 0029021176 scopus 로고
    • Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RIβ subunit of cAMP-dependent protein kinase
    • Brandon, E. P. et al. Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RIβ subunit of cAMP-dependent protein kinase. Proc. Natl Acad. Sci. USA. 92, 8851-8855 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 8851-8855
    • Brandon, E.P.1
  • 77
    • 0029737861 scopus 로고    scopus 로고
    • Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
    • Cummings, D. E. et al. Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A. Nature 382, 622-626 (1996).
    • (1996) Nature , vol.382 , pp. 622-626
    • Cummings, D.E.1
  • 78
    • 0033587807 scopus 로고    scopus 로고
    • Deletion of type IIα regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization
    • Burton, K. A., Treash-Osio, B., Muller, C. H., Dunphy, E. L. & McKnight, G. S. Deletion of type IIα regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization. J. Biol. Chem. 274, 24131-24136 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 24131-24136
    • Burton, K.A.1    Treash-Osio, B.2    Muller, C.H.3    Dunphy, E.L.4    McKnight, G.S.5
  • 79
    • 3843115756 scopus 로고    scopus 로고
    • Reduced ocular dominance plasticity and long-term potentiation in the developing visual cortex of protein kinase A RIIα mutant mice
    • Rao, Y. et al. Reduced ocular dominance plasticity and long-term potentiation in the developing visual cortex of protein kinase A RIIα mutant mice. Eur. J. Neurosci. 20, 837-842 (2004).
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 837-842
    • Rao, Y.1
  • 80
    • 0037178847 scopus 로고    scopus 로고
    • Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo
    • Amieux, P. S. et al. Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J. Biol. Chem. 277, 27294-27304 (2002). Initial description of a Prkar1a-null mouse that demonstrates the key role of Prkar1a in early embryogenesis.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27294-27304
    • Amieux, P.S.1
  • 81
    • 0038721027 scopus 로고    scopus 로고
    • Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity
    • Bertherat, J. et al. Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity. Cancer Res. 63, 5308-5319 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 5308-5319
    • Bertherat, J.1
  • 82
    • 7444257863 scopus 로고    scopus 로고
    • Eyelid myxoma in Carney complex without PRKAR1A allelic loss
    • Tsilou, E. T. et al. Eyelid myxoma in Carney complex without PRKAR1A allelic loss. Am. J. Med. Genet. 130, 395-397 (2004).
    • (2004) Am. J. Med. Genet. , vol.130 , pp. 395-397
    • Tsilou, E.T.1
  • 83
    • 0026347794 scopus 로고
    • Report of the committee on chromosome and gene loss in neoplasia
    • Seizinger, B. R. et al. Report of the committee on chromosome and gene loss in neoplasia. Cytogenet. Cell Genet. 58, 1080-1096 (1991).
    • (1991) Cytogenet. Cell Genet. , vol.58 , pp. 1080-1096
    • Seizinger, B.R.1
  • 84
    • 0036518741 scopus 로고    scopus 로고
    • Does heart rate identify sudden death survivors? Assessment of heart rate, QT interval, and heart rate variability
    • Molnar, J., Weiss, J. S. & Rosenthal, J. E. Does heart rate identify sudden death survivors? Assessment of heart rate, QT interval, and heart rate variability. Am. J. Ther. 9, 99-110 (2002).
    • (2002) Am. J. Ther. , vol.9 , pp. 99-110
    • Molnar, J.1    Weiss, J.S.2    Rosenthal, J.E.3
  • 85
    • 14144253077 scopus 로고    scopus 로고
    • Different spectral components of 24h heart rate variability are related to different modes of death in chronic heart failure
    • Guzzetti, S. et al. Different spectral components of 24h heart rate variability are related to different modes of death in chronic heart failure. Eur. Heart J. 26, 357-362 (2005).
    • (2005) Eur. Heart J. , vol.26 , pp. 357-362
    • Guzzetti, S.1
  • 86
  • 87
    • 11244256703 scopus 로고    scopus 로고
    • A mouse model for Carney complex
    • Griffin, K. J. et al. A mouse model for Carney complex. Endocr. Res. 30, 903-911 (2004).
    • (2004) Endocr. Res. , vol.30 , pp. 903-911
    • Griffin, K.J.1
  • 88
    • 19644364776 scopus 로고    scopus 로고
    • A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues
    • Kirschner, L. S. et al. A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res. 65, 4506-4514 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 4506-4514
    • Kirschner, L.S.1
  • 89
    • 0036736814 scopus 로고    scopus 로고
    • Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease
    • Groussin, L. et al. Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. J. Clin. Endocrinol. Metab. 87, 4324-4329 (2002).
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4324-4329
    • Groussin, L.1
  • 90
    • 0036291366 scopus 로고    scopus 로고
    • Role of the PKA-regulated transcription factor CREB in development and tumorigenesis of endocrine tissues
    • Rosenberg, D. et al. Role of the PKA-regulated transcription factor CREB in development and tumorigenesis of endocrine tissues. Ann. NY Acad. Sci. 968, 65-74 (2002).
    • (2002) Ann. NY Acad. Sci. , vol.968 , pp. 65-74
    • Rosenberg, D.1
  • 91
    • 0025266685 scopus 로고
    • Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB
    • Ghosh, S. & Baltimore, D. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344, 678-682 (1990).
    • (1990) Nature , vol.344 , pp. 678-682
    • Ghosh, S.1    Baltimore, D.2
  • 92
    • 0034141636 scopus 로고    scopus 로고
    • LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
    • Collins, S. P., Reoma, J. L., Gamm, D. M. & Uhler, M. D. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem. J. 345, 673-680 (2000).
    • (2000) Biochem. J. , vol.345 , pp. 673-680
    • Collins, S.P.1    Reoma, J.L.2    Gamm, D.M.3    Uhler, M.D.4
  • 93
    • 10844227998 scopus 로고    scopus 로고
    • Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein
    • Lania, A. G. et al. Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein. Cancer Res. 64, 9193-9198 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 9193-9198
    • Lania, A.G.1
  • 94
    • 0000939974 scopus 로고    scopus 로고
    • Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue
    • Gordge, P. C., Hulme, M. J., Clegg, R. A. & Miller, W. R. Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue. Eur. J. Cancer 32A, 2120-2126 (1996).
    • (1996) Eur. J. Cancer , vol.32 A , pp. 2120-2126
    • Gordge, P.C.1    Hulme, M.J.2    Clegg, R.A.3    Miller, W.R.4
  • 95
    • 0028218440 scopus 로고
    • Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa
    • Bradbury, A. W. et al. Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa. Br. J. Cancer 69, 738-742 (1994).
    • (1994) Br. J. Cancer , vol.69 , pp. 738-742
    • Bradbury, A.W.1
  • 96
    • 0032587480 scopus 로고    scopus 로고
    • Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer
    • McDaid, H. M. et al. Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer. Br. J. Cancer 79, 933-939 (1999).
    • (1999) Br. J. Cancer , vol.79 , pp. 933-939
    • McDaid, H.M.1
  • 97
    • 0018181161 scopus 로고
    • Protein kinases in human renal cell carcinoma and renal cortex. A comparison of isozyme distribution and of responsive ness to adenosine 3′:5′-cyclic monophosphate
    • Fossberg, T. M., Doskeland, S. O. & Ueland, P. M. Protein kinases in human renal cell carcinoma and renal cortex. A comparison of isozyme distribution and of responsive ness to adenosine 3′:5′-cyclic monophosphate. Arch. Biochem. Biophys. 189, 272-281 (1978).
    • (1978) Arch. Biochem. Biophys. , vol.189 , pp. 272-281
    • Fossberg, T.M.1    Doskeland, S.O.2    Ueland, P.M.3
  • 98
    • 0021687564 scopus 로고
    • Distribution and properties of type I and type II binding proteins in the cyclic adenosine 3′:5′-monophosphate-dependent protein kinase system in Wilms' tumor
    • Nakajima, F., Imashuku, S., Wilimas, J., Champion, J. E. & Green, A. A. Distribution and properties of type I and type II binding proteins in the cyclic adenosine 3′:5′-monophosphate-dependent protein kinase system in Wilms' tumor. Cancer Res. 44, 5182-5187 (1984).
    • (1984) Cancer Res. , vol.44 , pp. 5182-5187
    • Nakajima, F.1    Imashuku, S.2    Wilimas, J.3    Champion, J.E.4    Green, A.A.5
  • 100
    • 0027220462 scopus 로고
    • Tumour cyclic AMP binding proteins: An independent prognostic factor for disease recurrence and survival in breast cancer
    • Miller, W. R., Watson, D. M., Jack, W., Chetty, U. & Elton, R. A. Tumour cyclic AMP binding proteins: an independent prognostic factor for disease recurrence and survival in breast cancer. Breast Cancer Res. Treat. 26, 89-94 (1993).
    • (1993) Breast Cancer Res. Treat. , vol.26 , pp. 89-94
    • Miller, W.R.1    Watson, D.M.2    Jack, W.3    Chetty, U.4    Elton, R.A.5
  • 101
    • 0030051727 scopus 로고    scopus 로고
    • Cyclic adenosine 3′,5′-monophosphate-binding proteins in human ovarian cancer: Correlations with clinicopathological features
    • Simpson, B. J. et al. Cyclic adenosine 3′,5′-monophosphate- binding proteins in human ovarian cancer: correlations with clinicopathological features. Clin. Cancer Res. 2, 201-206 (1996).
    • (1996) Clin. Cancer Res. , vol.2 , pp. 201-206
    • Simpson, B.J.1
  • 102
    • 0029050664 scopus 로고
    • A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth
    • Nesterova, M. & Cho-Chung, Y. S. A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth. Nature Med. 1, 528-533 (1995).
    • (1995) Nature Med. , vol.1 , pp. 528-533
    • Nesterova, M.1    Cho-Chung, Y.S.2
  • 104
    • 4243710821 scopus 로고    scopus 로고
    • Antisense DNA-targeting protein kinase A-RIA subunit: A novel approach to cancer treatment
    • Cho-Chung, Y. S. et al. Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment. Front. Biosci. 4, D898-D907 (1999). Review of therapeutic applications for manipulation of R1α signalling in malignant tumours.
    • (1999) Front. Biosci. , vol.4
    • Cho-Chung, Y.S.1
  • 105
    • 0042328100 scopus 로고    scopus 로고
    • Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A
    • Farrow, B. et al. Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134, 197-205 (2003).
    • (2003) Surgery , vol.134 , pp. 197-205
    • Farrow, B.1
  • 106
    • 0033816198 scopus 로고    scopus 로고
    • Targeting of epidermal growth factor receptor and protein kinase A: Molecular basis and therapeutic applications
    • Tortora, G. & Ciardiello, F. Targeting of epidermal growth factor receptor and protein kinase A: molecular basis and therapeutic applications. Ann. Oncol. 11, 777-783 (2000).
    • (2000) Ann. Oncol. , vol.11 , pp. 777-783
    • Tortora, G.1    Ciardiello, F.2
  • 107
    • 0034537149 scopus 로고    scopus 로고
    • Oligonucleotide sequence-specific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIα subunit
    • Nesterova, M. & Cho-Chung, Y. S. Oligonucleotide sequence-specific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIα subunit. Antisense Nucleic Acid Drug Dev. 10, 423-433 (2000).
    • (2000) Antisense Nucleic Acid Drug Dev. , vol.10 , pp. 423-433
    • Nesterova, M.1    Cho-Chung, Y.S.2
  • 108
    • 0036188072 scopus 로고    scopus 로고
    • Protein kinase A RIα antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation
    • Cho, Y. S. et al. Protein kinase A RIα antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation. Clin. Cancer Res. 8, 607-614 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 607-614
    • Cho, Y.S.1
  • 109
    • 0033598705 scopus 로고    scopus 로고
    • Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration
    • Wang, H. et al. Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration. Proc. Natl Acad. Sci. USA 96, 13989-13994 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 13989-13994
    • Wang, H.1


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