Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice

Antiviral Research

Volumn 52, Issue 1, 2001, Pages 55-62

  Smee, Donald F ^a   Bailey, Kevin W ^a   Wong, Min Hui ^a   Sidwell, Robert W ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Antiviral; Cidofovir; Pathogenesis; Vaccinia virus

Indexed keywords

CIDOFOVIR; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTERIAL OXYGEN SATURATION; ARTICLE; BLOOD; BRAIN; CONTROLLED STUDY; LIVER; LUNG PARENCHYMA; LUNG WEIGHT; MOUSE; NONHUMAN; NOSE; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PULSE OXIMETRY; SPLEEN; SURVIVAL; TISSUE DISTRIBUTION; TREATMENT OUTCOME; VACCINIA VIRUS; VIRUS REPLICATION; VIRUS TRANSMISSION; WEIGHT GAIN;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIVIRAL AGENTS; BLOOD GAS MONITORING, TRANSCUTANEOUS; BODY WEIGHT; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CYTOSINE; INJECTIONS, INTRAPERITONEAL; LUNG; MICE; MICE, INBRED BALB C; ORGAN SIZE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PLAQUE ASSAY; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTIONS; TIME FACTORS; VACCINIA; VACCINIA VIRUS; VERO CELLS; VIRUS REPLICATION;

ANIMALIA; VACCINIA; VACCINIA VIRUS;

EID: 0034877280     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00159-0     Document Type: Article

References (28)

1. Cidofovir (HPMPC) protects mice against lethal aerosol or intranasal cowpox virus challenge
2. Poxvirus dilemmas - Monkeypox, smallpox and biological terrorism
3. Topical cidofovir for severe molluscum contagiosum
4. Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo
5. Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections
6. Poxvirus dilemmas
7. Efficacy of cidofovir in the treatment of recalcitrant molluscum contagiosum in an AIDS patient
8. Progressive vaccinia treated with ribavirin and vaccinia immune globulin
9. Vaccinia virus envelope H3L protein binds to cell surface heparan sulfate and is important for intracellular mature virion morphogenesis and virus infection in vitro and in vivo
10. A mouse model of aerosol-transmitted orthopoxviral disease: Morphology of experimental aerosol-transmitted orthopoxviral disease in a cowpox virus-BALB/c mouse system
11. Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiency virus-infected patients treated with cidofovir
12. The behavior of pox viruses in the respiratory tract. I. The response of mice to the nasal instillation of vaccinia virus
13. Parapoxviruses are strongly inhibited in vitro by cidofovir
14. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice
15. Efficacy of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine for the treatment of vaccinia virus (orthopoxvirus) infections in mice
16. Protective effect of 5-iodo-2′-deoxyuridine (IDU) against vaccinia virus infections in SCID mice
17. Escape from Moscow
18. The antiviral activity of 9-β-D-arabinofuranosyladenine (Ara-A)
19. Effect of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole, ICN 1229) on herpes and vaccinia keratitis and encephalitis in laboratory animals
20. Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice
21. Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor
22. Adenine arabinoside: Chemotherapy studies in animals
23. Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir
24. Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir
25. Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir
26. Topical cidofovir: A novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1
27. Respiratory infection of mice with vaccinia virus
28. Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects