메뉴 건너뛰기




Volumn 24, Issue 3, 2006, Pages 327-329

Gemcitabine doublets in advanced pancreatic cancer: Should we move on?

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CETUXIMAB; ERLOTINIB; ETOPOSIDE; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; PLATINUM COMPLEX; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; CISPLATIN; DEOXYCYTIDINE; DRUG DERIVATIVE;

EID: 33644838236     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.03.8315     Document Type: Editorial
Times cited : (10)

References (31)
  • 1
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first- line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA, Moore MJ, Andersen J, et al: Improvements in survival and clinical benefit with gemcitabine as first- line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15:2403-2413, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 2
    • 0029816590 scopus 로고    scopus 로고
    • Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer
    • Glimelius B, Hoffman K, Sjoden PO, et al: Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 7:593-600, 1996
    • (1996) Ann Oncol , vol.7 , pp. 593-600
    • Glimelius, B.1    Hoffman, K.2    Sjoden, P.O.3
  • 3
    • 0028292341 scopus 로고
    • Phase II trial of gemcitabine (2,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas
    • Casper ES, Green MR, Kelsen DP, et al: Phase II trial of gemcitabine (2,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 12:29-34, 1994
    • (1994) Invest New Drugs , vol.12 , pp. 29-34
    • Casper, E.S.1    Green, M.R.2    Kelsen, D.P.3
  • 4
    • 0029809541 scopus 로고    scopus 로고
    • Gemcitabine: Preclinical pharmacology and mechanisms of action
    • suppl 10
    • Plunkett W, Huang P, Searcy CE, et al: Gemcitabine: Preclinical pharmacology and mechanisms of action. Semin Oncol 23:3-15, 1996 (suppl 10)
    • (1996) Semin Oncol , vol.23 , pp. 3-15
    • Plunkett, W.1    Huang, P.2    Searcy, C.E.3
  • 5
    • 0025089191 scopus 로고
    • Pharmacologically directed design of the dose rate and schedule of 2′,2′-difluorodeoxycytidine (Gemcitabine) administration in leukemia
    • Grunewald R, Kantarjian H, Keating MJ, et al: Pharmacologically directed design of the dose rate and schedule of 2′,2′-difluorodeoxycytidine (Gemcitabine) administration in leukemia. Cancer Res 50:6823-6826, 1990
    • (1990) Cancer Res , vol.50 , pp. 6823-6826
    • Grunewald, R.1    Kantarjian, H.2    Keating, M.J.3
  • 6
    • 0025978216 scopus 로고
    • A phase I clinical, plasma, and cellular pharmacology study of gemcitabine
    • Abbruzzese JL, Grunewald R, Weeks EA, et al: A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol 9:491-498, 1991
    • (1991) J Clin Oncol , vol.9 , pp. 491-498
    • Abbruzzese, J.L.1    Grunewald, R.2    Weeks, E.A.3
  • 7
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero M, Plunkett W, Ruiz Van Haperen V, et al: Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 21:3402-3408, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz Van Haperen, V.3
  • 8
    • 0033012340 scopus 로고    scopus 로고
    • Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer
    • Hidalgo M, Castellano D, Paz-Ares L, et al: Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer. J Clin Oncol 17:585-592, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 585-592
    • Hidalgo, M.1    Castellano, D.2    Paz-Ares, L.3
  • 9
    • 0034029777 scopus 로고    scopus 로고
    • A phase II study of gemcitabine and 5-fluorouracil in metastatic pancreatic cancer: An Eastern Cooperative Oncology Group Study (E3296)
    • Berlin JD, Adak S, Vaughn DJ, et al: A phase II study of gemcitabine and 5-fluorouracil in metastatic pancreatic cancer: An Eastern Cooperative Oncology Group Study (E3296). Oncology 58:215-218, 2000
    • (2000) Oncology , vol.58 , pp. 215-218
    • Berlin, J.D.1    Adak, S.2    Vaughn, D.J.3
  • 10
    • 0036498787 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine induces both radiographic and CA 19-9 tumor marker responses in patients with previously untreated advanced pancreatic cancer
    • Rocha Lima CM, Savarese D, Bruckner H, et al: Irinotecan plus gemcitabine induces both radiographic and CA 19-9 tumor marker responses in patients with previously untreated advanced pancreatic cancer. J Clin Oncol 20:1182-1191, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 1182-1191
    • Rocha Lima, C.M.1    Savarese, D.2    Bruckner, H.3
  • 11
    • 0033783408 scopus 로고    scopus 로고
    • Phase II study of gemcitabine in combination with cisplatin in patients with locally advanced and/or metastatic pancreatic cancer
    • Brodowicz T, Wolfram RM, Kostler WJ, et al: Phase II study of gemcitabine in combination with cisplatin in patients with locally advanced and/or metastatic pancreatic cancer. Anticancer Drugs 11:623-628, 2000
    • (2000) Anticancer Drugs , vol.11 , pp. 623-628
    • Brodowicz, T.1    Wolfram, R.M.2    Kostler, W.J.3
  • 12
    • 0035425508 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma
    • Philip PA, Zalupski MM, Vaitkevicius VK, et al: Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma. Cancer 92:569-577, 2001
    • (2001) Cancer , vol.92 , pp. 569-577
    • Philip, P.A.1    Zalupski, M.M.2    Vaitkevicius, V.K.3
  • 13
    • 0037087787 scopus 로고    scopus 로고
    • Gemcitabine combined with oxaliplatin in advanced pancreatic adenocarcinoma: Final results of a GERCOR multicenter phase II study
    • Louvet C, Andre T, Lledo G, et al: Gemcitabine combined with oxaliplatin in advanced pancreatic adenocarcinoma: Final results of a GERCOR multicenter phase II study. J Clin Oncol 20:1512-1518, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 1512-1518
    • Louvet, C.1    Andre, T.2    Lledo, G.3
  • 14
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, et al: Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 20:3270-3275, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3
  • 15
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • Rocha Lima CM, Green MR, Rotche R, et al: Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 22:776-3783, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 776-3783
    • Rocha Lima, C.M.1    Green, M.R.2    Rotche, R.3
  • 16
    • 27144530079 scopus 로고    scopus 로고
    • A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
    • Oettle H, Richards D, Ramanathan RK, et al: A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol 16:1639-1645, 2005
    • (2005) Ann Oncol , vol.16 , pp. 1639-1645
    • Oettle, H.1    Richards, D.2    Ramanathan, R.K.3
  • 17
    • 16444384413 scopus 로고    scopus 로고
    • A randomized phase III trial of DX-8951f (exatecan mesylate; DX) and gemcitabine (GEM) vs. gemcitabine alone in advanced pancreatic cancer (APC)
    • suppl 14; abstr 4006, 314s
    • O'Reilly M, Abou-Alfa G, Letourneau R, et al: A randomized phase III trial of DX-8951f (exatecan mesylate; DX) and gemcitabine (GEM) vs. gemcitabine alone in advanced pancreatic cancer (APC). J Clin Oncol 22:314s, 2004 (suppl 14; abstr 4006)
    • (2004) J Clin Oncol , vol.22
    • O'Reilly, M.1    Abou-Alfa, G.2    Letourneau, R.3
  • 18
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: A prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • Colucci G, Giuliani F, Gebbia V, et al: Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: A prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 94:902-910, 2002
    • (2002) Cancer , vol.94 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3
  • 19
    • 1542358227 scopus 로고    scopus 로고
    • A phase III trial comparing gemcitabine plus cisplatin vs. gemcitabine alone in advanced pancreatic carcinoma
    • abstr 1003
    • Heinemann V, Quietzsch D, Gieseler F, et al: A phase III trial comparing gemcitabine plus cisplatin vs. gemcitabine alone in advanced pancreatic carcinoma. Proc Am Soc Clin Oncol 22:250, 2003 (abstr 1003)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 250
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3
  • 20
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
    • Louvet C, Labianca R, Hammel P, et al: Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial. J Clin Oncol 23:3509-3516, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3
  • 21
    • 0028784506 scopus 로고
    • Interaction between cisplatin and gemcitabine in vitro and in vivo
    • suppl 11
    • Peters GJ, Bergman AM, Ruiz van Haperen VWT, et al: Interaction between cisplatin and gemcitabine in vitro and in vivo. Semin Oncol 22:72-79, 1995 (suppl 11)
    • (1995) Semin Oncol , vol.22 , pp. 72-79
    • Peters, G.J.1    Bergman, A.M.2    Ruiz van Haperen, V.W.T.3
  • 22
    • 0029875635 scopus 로고    scopus 로고
    • Synergistic interaction between gemcitabine and cisplatin in vitro
    • Bergman AM, Ruiz van Haperen VWT, Veerman G, et al: Synergistic interaction between gemcitabine and cisplatin in vitro. Clin Cancer Res 2:521-530, 1996
    • (1996) Clin Cancer Res , vol.2 , pp. 521-530
    • Bergman, A.M.1    Ruiz van Haperen, V.W.T.2    Veerman, G.3
  • 23
    • 0029593648 scopus 로고
    • Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts
    • Braakhuis BJ, Ruiz van Haperen VW, Welters MJ, et al: Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts. Eur J Cancer 31A:2335-2340, 1995
    • (1995) Eur J Cancer , vol.31 A , pp. 2335-2340
    • Braakhuis, B.J.1    Ruiz van Haperen, V.W.2    Welters, M.J.3
  • 24
    • 0032990022 scopus 로고    scopus 로고
    • Supraadditive effect of 2′,2′-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines
    • Faivre S, Raymond E, Woynarowski JM, et al: Supraadditive effect of 2′,2′-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines. Cancer Chemother Pharmacol 44:117-123, 1999
    • (1999) Cancer Chemother Pharmacol , vol.44 , pp. 117-123
    • Faivre, S.1    Raymond, E.2    Woynarowski, J.M.3
  • 25
    • 33644845101 scopus 로고    scopus 로고
    • A phase II study of gemcitabine at fixed dose rate infusion in combination with low dose cisplatin for metastatic adenocarcinoma of the pancreas
    • Ko AH, Dito E, Shillinger B, et al: A phase II study of gemcitabine at fixed dose rate infusion in combination with low dose cisplatin for metastatic adenocarcinoma of the pancreas. J Clin Oncol 24:379-385, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 379-385
    • Ko, A.H.1    Dito, E.2    Shillinger, B.3
  • 26
    • 0030813204 scopus 로고    scopus 로고
    • Phase I study of gemcitabine using a once every 2 weeks schedule
    • Vermorken JB, Guastalla JP, Hatty SR, et al: Phase I study of gemcitabine using a once every 2 weeks schedule. Br J Cancer 76:1489-1493, 1997
    • (1997) Br J Cancer , vol.76 , pp. 1489-1493
    • Vermorken, J.B.1    Guastalla, J.P.2    Hatty, S.R.3
  • 27
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, Van de Velde H, Karasek P, et al: Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 22:1430-1438, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 1430-1438
    • Van Cutsem, E.1    Van de Velde, H.2    Karasek, P.3
  • 28
    • 0037100983 scopus 로고    scopus 로고
    • A double blind placebo controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, et al: A double blind placebo controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 87:161-167, 2002
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3
  • 29
    • 84871470185 scopus 로고    scopus 로고
    • Bevacizumab (B) plus gemcitabine (G) in patients with advanced pancreatic cancer: Updated results of a multi-center trial
    • suppl 14; abstr 4009, 315s
    • Kindler HL, Friberg G, Stadler WM, et al: Bevacizumab (B) plus gemcitabine (G) in patients with advanced pancreatic cancer: Updated results of a multi-center trial. J Clin Oncol 22:315s, 2004 (suppl 14; abstr 4009)
    • (2004) J Clin Oncol , vol.22
    • Kindler, H.L.1    Friberg, G.2    Stadler, W.M.3
  • 30
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
    • Xiong HQ, Rosenberg A, LoBuglio A, et al: Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial. J Clin Oncol 22:2610-2616, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    LoBuglio, A.3
  • 31
    • 29044439943 scopus 로고    scopus 로고
    • Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trial Group (NCIC-CTG)
    • Orlando, FL, January 27-29, abstr 77
    • Moore MJ, Goldstein D, Hamm J, et al: Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trial Group (NCIC-CTG). Proc 2005 Gastrointestinal Cancers Symposium, Orlando, FL, January 27-29, 2005 (abstr 77)
    • (2005) Proc 2005 Gastrointestinal Cancers Symposium
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.