Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae

Molecular and Biochemical Parasitology

Volumn 146, Issue 2, 2006, Pages 255-258

  Kessl, Jacques J ^a   Ha, Kevin H ^a   Merritt, Anne K ^a   Meshnick, Steven R ^b   Trumpower, Bernard L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Atovaquone; Cytochrome bc1 complex; Drug resistance; Toxoplasma gondii

Indexed keywords

ATOVAQUONE; CYTOCHROME B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; IC 50; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; TOXOPLASMA GONDII; YEAST;

AMINO ACID SEQUENCE; ANIMALS; ATOVAQUONE; COCCIDIOSTATS; CYTOCHROMES B; DRUG RESISTANCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAPHTHOQUINONES; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; TOXOPLASMA;

SACCHAROMYCES CEREVISIAE; TOXOPLASMA GONDII;

EID: 33644821765     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.12.002     Document Type: Article

References (15)

1. J.D. Kravetz, and D.G. Federman Toxoplasmosis in pregnancy Am J Med 118 2005 212 216
2. M. Fry, and M. Pudney Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4′-chlorophenyl) cyclohexyl]-3-hydroxy- 1,4-naphthoquinone (566C80) Biochem Pharmacol 43 1992 1545 1553
3. W.T. Hughes, and H.S. Oz Successful prevention and treatment of babesiosis with atovaquone J Infect Dis 172 1995 1042 1046
4. J.S. Gray, and M. Pudney Activity of atovaquone against Babesia microti in the Mongolian gerbil, Meriones unguiculatus J Parasitol 85 1999 723 728
5. A.L. Baggish, and D.R. Hill Antiparasitic agent atovaquone Antimicrob Agents Chemother 46 2004 1163 1173
6. F.G. Araujo, J. Huskinson, and J.S. Remington Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii Antimicrob Agents Chemother 35 1991 293 299
7. 1 complex J Biol Chem 278 2003 31312 31318
8. R. McGready, E.A. Ashley, and E. Moo A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy J Infect Dis 192 2005 846 853
9. K. Na-bangchang, C. Manyando, and R. Ruengweerayut The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women Eur J Clin Pharmacol 61 2005 573 582
10. P. Hill, J. Kessl, N. Fisher, S. Meshnick, B.L. Trumpower, and B. Meunier Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci Antimicrob Agents Chemother 47 2003 2725 2731
11. 1 complex of Saccharomyces cerevisiae J Biol Chem 279 2004 2817 2824
12. 1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae J Biol Chem 280 2005 17142 17148
13. 0 domain mutations as a mechanism of atovaquone-resistance Mol Biochem Parasitol 108 2000 1 12
14. o site inhibitor bound J Biol Chem 278 2003 31303 31311
15. J. Pranata Sulfur-aromatic interactions: a computational study of the dimethyl sulfide-benzene complex Bioorg Chem 25 1997 213 219