Modelling and imaging cardiac repolarization abnormalities

Journal of Internal Medicine

Volumn 259, Issue 1, 2006, Pages 91-106

  Rudy, Y ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Cardiac arrhythmias; Cardiac electrophysiology; Electrocardiography; Long QT syndrome

Indexed keywords

ARGININE; ASPARAGINE; ASPARTIC ACID; GLUTAMINE; ISOLEUCINE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNQ1; POTASSIUM ION; THREONINE; KCNH2 PROTEIN, HUMAN; POTASSIUM CHANNEL;

ADAPTATION; AMINO ACID SUBSTITUTION; BIOLOGY; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; DATA ANALYSIS SOFTWARE; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; ELECTROCARDIOGRAPHY; ELECTROCARDIOGRAPHY MONITORING; EPICARDIUM; GENE; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HERG GENE; HUMAN; KINETICS; LONG QT SYNDROME; MOLECULAR INTERACTION; NON INVASIVE MEASUREMENT; NONHUMAN; POINT MUTATION; POTASSIUM CURRENT; PRIORITY JOURNAL; PROBABILITY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QT INTERVAL; REENTRY ARRHYTHMIA; RISK ASSESSMENT; WHOLE CELL; ACTION POTENTIAL; ANIMAL; ARTICLE; COMPUTER SIMULATION; CONFORMATION; DISEASE MODEL; GENETICS; GUINEA PIG; HEART; METHODOLOGY; MUTATION; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY;

ACTION POTENTIALS; ADAPTATION, PHYSIOLOGICAL; ANIMALS; ARRHYTHMIA; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ETHER-A-GO-GO POTASSIUM CHANNELS; GUINEA PIGS; HEART; LONG QT SYNDROME; MARKOV CHAINS; MOLECULAR CONFORMATION; MUTATION; PHENOTYPE; POTASSIUM CHANNELS; RISK ASSESSMENT;

EID: 33644820193     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2005.01586.x     Document Type: Conference Paper

References (47)

1. Keating MT Sanguinetti MC. Molecular genetic insights into cardiovascular disease Science 1996 272 681 5
2. Clancy CE Rudy Y. Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia Nature 1999 400 566 9
3. Clancy CE Rudy Y. Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death Cardiovasc Res 2001 50 301 13
4. Ks participation in cardiac repolarization and repolarization reserve Circulation 2005 112 1384 91
5. Ramanathan C Ghanem RN Jia P Ryu K Rudy Y. Electrocardiographic imaging (ECGI): a noninvasive imaging modality for cardiac electrophysiology and arrhythmia Nature Med 2004 10 422 8
6. Luo C Rudy Y. A dynamic model of the cardiac ventricular action potential: I. Simulations of ionic currents and concentration changes Circ Res 1994 74 1071 96
7. +]i overloaded cardiac myocytes: a simulation study Biophys J 2000 78 2392 404
8. Rudy Y. The cardiac ventricular action potential In Page E Fozzard HA Solaro RJ eds Handbook of Physiology: the Heart
9. + channel mutation that causes both Brugada and long QT syndrome phenotypes: a simulation study of mechanism Circulation 2002 105 1208 13
10. Roden DM Balser JR. A plethora of mechanisms in the HERG-related long-QT syndrome: genetics meets electrophysiology Cardiovasc Res 1999 44 242 6
11. Zhou Z Gong Q Epstein ML January CT. HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects J Biol Chem 1998 273 21061 6
12. Hund TJ Rudy Y. Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model Circulation 2004 110 3168 74
13. Zhou Z Gong Q Epstein ML January CT. HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects J Biol Chem 1998 273 21061 6
14. Nakajima T Furukawa T Tanaka T et al. Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation Circ Res 1998 83 415 22
15. Chen J Zou A Splawski I Keating MT Sanguinetti MC. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation J Biol Chem 1999 274 10113 8
16. + channel related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant Circ Res 2000 86 507 13
17. Liu DW Gintant GA Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle Circ Res 1993 72 671 87
18. Zeng J Rudy Y. Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence Biophys J 1995 68 949 64
19. Bennett PB Yazawa K Makita N et al. Molecular mechanism for an inherited cardiac arrhythmia Nature 1995 376 683 5
20. Duggal P Vesely MR Wattanasirichaigoon D Villafane J Kaushik V Beggs AH. Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome Circulation 1998 97 142 6
21. Splawski I Tristani-Firouzi M Lehmann MH Sanguinetti MC Keating MT. Mutations in the hminK gene cause long QT syndrome and suppress IKs function Nat Genet 1997 17 338 40
22. Marx SO Kurokawa J Reiken S et al. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel Science 2002 295 496 9
23. Roden DM. Review in this issue of J Intern Med
24. Lu Z Kamiya K Opthof T Yasui K Kodama I. Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans Circulation 2001 104 951 6
25. Zagotta WN Hoshi T Aldrich RW. Shaker potassium channel gating. III: evaluation of kinetic models for activation J Gen Physiol 1994 103 321 62
26. + channels PNAS 2003 100 2935 40
27. + channel (mink) subunits J Physiol 1998 510 Pt 1 37 45
28. Cui J Kline RP Pennefather P Cohen IS. Gating of IsK expressed in Xenopus oocytes depends on the amount of mRNA injected J Gen Physiol 1994 104 87 105
29. Koren G Liman ER Logothetis DE Nadal-Ginard B Hess P. Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells Neuron 1990 4 39 51
30. Rocchetti M Besana A Gurrola GB Possani LD Zaza A. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential J Physiol 2001 534 721 32
31. Roden DM. Drug-induced prolongation of the QT interval N Engl J Med 2004 350 1013 22
32. Ks to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation Circ 2003 107 2753 60
33. Kay NG Plumb VJ Arciniegas JG Henthorn RW Waldo AL. Torsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patients J Am Coll Cardiol 1983 2 806 17
34. Viswanathan PC Rudy Y. Pause induced early afterdepolarizations in the long QT syndrome: a simulation study Cardiovasc Res 199 42 530 42
35. Rudy Y Burnes JE. Noninvasive electrocardiographic imaging (ECGI) Annals of Noninvasive Electrocardiology 1999 4 340 359
36. Oster HS Taccardi B Lux RL Ershler PR Rudy Y. Noninvasive electrocardiographic imaging: reconstruction of epicardial potentials, electrograms and isochrones, and localization of single and multiple electrocardiac events Circulation 1997 96 1012 24
37. Oster HS Taccardi B Lux RL Ershler PR Rudy Y. Electrocardiographic imaging: noninvasive characterization of intramural myocardial activation from inverse reconstructed epicardial potentials and electrograms Circulation 1998 97 1496 507
38. Burnes JE Taccardi B MacLeod RS Rudy Y. Noninvasive electrocardiographic imaging of electrophysiologically abnormal substrate in infracted hearts: a model study Circulation 2000 101 533 40
39. Burnes JE Taccardi B Rudy Y. A noninvasive imaging modality for cardiac arrhythmias Circulation 2000 102 2152 8
40. Ramanathan C Rudy Y. Electrocardiographic imaging: II. Effect of torso inhomogeneities on the noninvasive reconstruction of epicardial potentials, electrograms and isochrones J Cardiovasc Electrophysiol 2001 12 241 52
41. Burnes JE Taccardi B Ershler P Rudy Y. Noninvasive ECG imaging of substrate and intramural ventricular tachycardia in infracted hearts J Am Coll Cardiol 2001 38 2071 8
42. Ramanathan C Jia P Ghanem RN Calvetti D Rudy Y. Noninvasive electrocardiographic imaging (ECGI): application of the generalized minimal residual (GMRes) method Ann Biomed Eng 2003 31 981 94
43. Ghanem RN Burnes JE Waldo AL Rudy Y. Imaging dispersion of myocardial repolarization II. Noninvasive reconstruction of epicardial measures Circulation 2001 104 1306 12
44. Ghanem RN Jia P Ramanathan C Ryu K Markowitz A Rudy Y. Noninvasive electrocardiographic imaging (ECGI): comparison to intraoperative mapping in patients Heart Rhythm J 2005 2 339 54
45. Yamabe H Misumi I Fukushima H Ueno K Kimura Y Hokamura Y. Conduction properties of the crista terminalis and its influence on the right atrial activation sequence in patients with typical atrial flutter Pacing Clin Electrophysiol 2002 25 132 41
46. Daoud EG Morady F. Pathophysiology of atrial flutter Ann Rev Med 1998 49 77 83
47. Rodriguez L-M Timmermans C Nabar A Hofstra L Wellens HJJ. Biatrial activation in isthmus-dependent atrial flutter Circulation 2001 104 2545 50