Dose-dependent induction of IL-6 by plant-derived proteases in vitro

Clinical and Experimental Immunology

Volumn 143, Issue 1, 2006, Pages 85-92

  Rose, B ^a   Herder, C ^a   Loffler H ^a   Meierhoff, G ^a   Schloot, N C ^a   Walz, M ^a   Martin, S ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Cytokines; IL 6; Immunomodulation; MMLC; Proteases

Indexed keywords

BROMELAIN; CD14 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; PAPAIN; POLYMYXIN B; PROTEINASE; ANTIINFECTIVE AGENT; IMMUNOSUPPRESSIVE AGENT; LIPOPOLYSACCHARIDE; PEPTIDE HYDROLASE;

ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; INNATE IMMUNITY; MIXED LYMPHOCYTE CULTURE; NORMAL HUMAN; PLANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; TISSUE REGENERATION; WOUND HEALING; ANALYSIS OF VARIANCE; CELL SURVIVAL; DRUG EFFECT; IMMUNOLOGY; LYMPHOCYTE;

ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; ANTIGENS, CD14; BROMELAINS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTES; PAPAIN; PEPTIDE HYDROLASES; POLYMYXIN B; WOUND HEALING;

EID: 33644819544     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02970.x     Document Type: Article

References (41)

1. Maurer HR Bromelain: biochemistry, pharmacology and medical use Cell Mol Life Sci 2001 58 1234 45
2. Leipner J Iten F Saller R Therapy with proteolytic enzymes in rheumatic disorders Biodrugs 2001 15 779 89
3. Shahid SK Turakhia NH Kundra M Shanbag P Daftary GV Schiess W Efficacy and safety of phlogenzym - a protease formulation, in sepsis in children J Assoc Physicians India 2002 50 527 31
4. Desser L Rehberger A Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes Oncology 1990 47 475 7
5. Desser L Rehberger A Paukovits W Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro Cancer Biother 1994 9 253 63
6. Engwerda CR Andrew D Murphy M Mynott TL Bromelain activates murine macrophages and natural killer cells in vitro Cell Immunol 2001 210 5 10
7. Desser L Rehberger A Kokron E Paukovits W Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations Oncology 1993 50 403 7
8. Desser L Holomanova D Zavadova E Pavelka K Mohr T Herbacek I Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood Cancer Chemother Pharmacol 2001 47 S10 S15
9. Mynott TL Ladhams A Scarmato P Engwerda CR Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells J Immunol 1999 163 2568 75
10. Hale LP Haynes BF Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation J Immunol 1992 149 3809 16
11. Munzig E Eckert K Harrach T Graf H Maurer HR Bromelain protease F9 reduces the CD44 mediated adhesion of human peripheral blood lymphocytes to human umbilical vein endothelial cells FEBS Lett 1994 351 215 8
12. Targoni OS Tary-Lehmann M Lehmann PV Prevention of murine EAE by oral hydrolytic enzyme treatment J Autoimmun 1999 12 191 8
13. Paczek L Gaciong Z Bartlomiejczyk I Sebekova K Birkenmeier G Heidland A Protease administration decreases enhanced transforming growth factor-beta 1 content in isolated glomeruli of diabetic rats Drugs Exp Clin Res 2001 27 141 9
14. Engwerda CR Andrew D Ladhams A Mynott TL Bromelain modulates T cell and B cell immune responses in vitro and in vivo Cell Immunol 2001 210 66 75
15. Manhart N Akomeah R Bergmeister H Spittler A Ploner M Roth E Administration of proteolytic enzymes bromelain and trypsin diminish the number of CD4+ cells and the interferon-gamma response in Peyer's patches and spleen in endotoxemic balb/c mice Cell Immunol 2002 215 113 9
16. Roep BO van den Engel NK van Halteren AG Duinkerken G Martin S Modulation of autoimmunity to beta-cell antigens by proteases Diabetologia 2002 45 686 92
17. Rose B Herder C Loffler H Kolb H Martin S Combined activation of innate and T cell immunity for recognizing immunomodulatory properties of therapeutic agents J Leukoc Biol 2004 75 624 30
18. Diehl S Rincon M The two faces of IL-6 on Th1/Th2 differentiation Mol Immunol 2002 39 531 6
19. Nielsen H Isolation and functional activity of human blood monocytes after adherence to plastic surfaces: comparison of different detachment methods Acta Pathol Microbiol Immunol Scand [C] 1987 95 81 4
20. Dery O Corvera CU Steinhoff M Bunnett NW Proteinase-activated receptors: novel mechanisms of signaling by serine proteases Am J Physiol 1998 274 C1429 C1452
21. Mackie EJ Pagel CN Smith R de Niese MR Song SJ Pike RN Protease-activated receptors: a means of converting extracellular proteolysis into intracellular signals IUBMB Life 2002 53 277 81
22. Ladel CH Blum C Dreher A Reifenberg K Kopf M Kaufmann SH Lethal tuberculosis in interleukin-6-deficient mutant mice Infect Immun 1997 65 4843 9
23. Anguita J Rincon M Samanta S Barthold SW Flavell RA Fikrig E Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis J Infect Dis 1998 178 1512 5
24. Williams DM Grubbs BG Darville T Kelly K Rank RG A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection Infect Immun 1998 66 4564 7
25. Khalil A Tullus K Bartfai T Bakhiet M Jaremko G Brauner A Renal cytokine responses in acute Escherichia coli pyelonephritis in IL-6-deficient mice Clin Exp Immunol 2000 122 200 6
26. Suzuki Y Rani S Liesenfeld O et al. Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice Infect Immun 1997 65 2339 45
27. Gao W Pereira MA Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi Int J Parasitol 2002 32 167 70
28. Bienz M Dai WJ Welle M Gottstein B Muller N Interleukin-6-deficient mice are highly susceptible to Giardia lamblia infection but exhibit normal intestinal immunoglobulin A responses against the parasite Infect Immun 2003 71 1569 73
29. Cenci E Mencacci A Casagrande A Mosci P Bistoni F Romani L Impaired antifungal effector activity but not inflammatory cell recruitment in interleukin-6-deficient mice with invasive pulmonary aspergillosis J Infect Dis 2001 184 610 7
30. Gallucci RM Simeonova PP Matheson JM Kommineni C Guriel JL Sugawara T Luster MI Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice FASEB J 2000 14 2525 31
31. Kovalovich K DeAngelis RA Li W Furth EE Ciliberto G Taub R Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice Hepatology 2000 31 149 59
32. Lin ZQ Kondo T Ishida Y Takayasu T Mukaida N Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice J Leukoc Biol 2003 73 713 21
33. Swartz KR Liu F Sewell D Schochet T Campbell I Sandor M Fabry Z Interleukin-6 promotes post-traumatic healing in the central nervous system Brain Res 2001 896 86 95
34. Gallucci RM Sloan DK Heck JM Murray AR O'Dell SJ Interleukin 6 indirectly induces keratinocyte migration J Invest Dermatol 2004 122 764 72
35. Xu XJ Hao JX Andell-Jonsson S Poli V Bartfai T Wiesenfeld-Hallin Z Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section Cytokine 1997 9 1028 33
36. Molotkov A Satoh M Tohyama C Tumor growth and food intake in interleukin-6 gene knock-out mice Cancer Lett 1998 132 187 92
37. Nemeth E Rivera S Gabayan V Keller C Taudorf S Pedersen BK Ganz T IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 2004 113 1271 6
38. Martin S Maruta K Burkart V Gillis S Kolb H IL-1 and IFN-gamma increase vascular permeability Immunology 1988 64 301 5
39. Castell JV Friedrich G Kuhn CS Poppe GE Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake Am J Physiol 1997 273 G139 G146
40. Paczek L Kropiewnicka EH Bartlomiejczyk I Gradowska L Heidland A Wood G Systemic proteolytic enzyme treatment diminishes urinary interleukin 6 in diabetic patients Nephron 2000 84 194 5
41. Desser L Sakalova A Zavadova E Holomanova D Mohr T Concentrations of soluble tumor necrosis factor receptors, beta2-microglobulin, IL-6 and TNF in serum of multiple myeloma patients after chemotherapy and after combined enzyme-therapy Int J Immunotherapy 1997 13 121 30