Antihyperalgesic activity of a novel nonpeptide bradykinin B 1 receptor antagonist in transgenic mice expressing the human B 1 receptor

British Journal of Pharmacology

Volumn 144, Issue 7, 2005, Pages 889-899

  Fox, Alyson ^a   Kaur, Satbir ^b,c   Li, Bifang ^b   Panesar, Moh ^a   Saha, Uma ^b   Davis, Clare ^a   Dragoni, Ilaria ^a   Colley, Sian ^a   Ritchie, Tim ^a   Bevan, Stuart ^a   Burgess, Gillian ^a,d   McIntyre, Peter ^a  

^a Novartis Inst for Medical Sciences   (United Kingdom)

^b Xenogen Biosciences   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Human B 1 receptor knockin; Hyperalgesia; Inflammation; Kinin B 1 receptor

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; CALCIUM ION; COMPLEMENTARY DNA; CRE RECOMBINASE; FREUND ADJUVANT; KALLIDIN[1-9]; LIPOPOLYSACCHARIDE; MESSENGER RNA; NVP SAA164; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN COS1; CELL STRAIN HEK293; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE INSERTION; HUMAN; HUMAN CELL; HYPERALGESIA; IN VIVO STUDY; INFLAMMATION; LOCOMOTION; LOXP SITE; MALE; MONKEY; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TAIL FLICK TEST; TRANSGENIC MOUSE;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; BENZAMIDES; CELL LINE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPERALGESIA; MACACA MULATTA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RATS; RECEPTOR, BRADYKININ B1; SULFONAMIDES;

EID: 17844367333     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706139     Document Type: Article

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