Ethanol inhibition of NMDA receptors under conditions of altered protein kinase A activity

Journal of Neurochemistry

Volumn 96, Issue 6, 2006, Pages 1760-1767

  Xu, Minfu ^a   Woodward, John J ^a,b  

^a MUSC Center for Drug and Alcohol Programs   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Electrophysiology; Human embryonic kidney 293 cells; Phosphorylation; Transfection

Indexed keywords

ALCOHOL; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE 1 RECEPTOR; ENZYME INHIBITOR; INHIBITOR PROTEIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PHOSPHATASE; RECOMBINANT RECEPTOR; SCAFFOLD PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL STRAIN HEK293; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; ENZYME ACTIVITY; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; INHIBITION KINETICS; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PATCH CLAMP; PIPETTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECORDING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANIMALS, NEWBORN; BRAIN; CELL LINE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBRAL CORTEX; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETAL PROTEINS; ETHANOL; HIPPOCAMPUS; HUMANS; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; RECEPTORS, N-METHYL-D-ASPARTATE; TRANSFECTION; UP-REGULATION;

ANIMALIA;

EID: 33644798558     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03703.x     Document Type: Article

References (34)

1. Alvestad RM. Grosshans DR. Coultrap SJ. Nakazawa T. Yamamoto T. Browning MD. 2003 Tyrosine dephosphorylation and ethanol inhibition of N-methyl- d -aspartate receptor function JBiolChem 278 11 020 11 025
2. Anders DL. Blevins T. Sutton G. Swope S. Chandler LJ. Woodward JJ. 1999 Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK293 cells JNeurochem 72 1389 1393
3. Anders DL. Blevins TL. Smothers CT. Woodward JJ. 2000 Reduced ethanol inhibition of N-methyl- d -aspartate receptors by deletion of the NR1 C0 domain or overexpression of α-actinin-2 proteins JBiolChem 275 15 019 15 024
4. Banke TG. Bowie D. Lee H. Huganir RL. Schousboe A. Traynelis SF. 2000 Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase JNeurosci 20 89 102
5. Blevins T. Mirshahi T. Chandler LJ. Woodward JJ. 1997 Effects of acute and chronic ethanol exposure on heteromeric N-methyl- d -aspartate receptors expressed in HEK293 cells JNeurochem 69 2345 2354
6. Carpenter-Hyland EP. Woodward JJ. Chandler LJ. 2004 Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors JNeurosci 24 7859 7868
7. Cepeda C. Colwell CS. Itri JN. Chandler SH. Levine MS. 1998 Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances JNeurophysiol 79 82 94
8. Chu B. Anantharam V. Treistman SN. 1995 Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators JNeurochem 65 140 148
9. Colledge M. Dean RA. Scott GK. Langeberg LK. Huganir RL. Scott JD. 2000 Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex Neuron 27 107 119
10. 1-dependent trafficking of striatal N-methyl- d -aspartate glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32 MolPharmacol 65 121 129
11. 1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl- d -aspartate receptors JBiolChem 278 20 196 20 202
12. 1 receptors and DARPP-32 JNeurophysiol 88 3010 3020
13. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits Neuron 19 185 196
14. 1 receptor Cell 111 219 230
15. Lin JW. Wyszynski M. Madhavan R. Sealock R. Kim JU. Sheng M. 1998 Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1 JNeurosci 18 2017 2027
16. Lovinger DM. White G. Weight FF. 1989 Ethanol inhibits NMDA-activated ion current in hippocampal neurons Science 243 1721 1724
17. Maldve RE. Zhang TA. Ferrani-Kile K. Schreiber SS. Lippmann MJ. Snyder GL. Fienberg AA. Leslie SW. Gonzales RA. Morrisett RA. 2002 DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens NatNeurosci 5 641 648
18. Masood K. Wu C. Brauneis U. Weight FF. 1994 Differential ethanol sensitivity of recombinant N-methyl- d -aspartate receptor subunits MolPharmacol 45 324 329
19. 2+-insensitive mutants Neuropharmacology 34 347 355
20. Mirshahi T. Anders DL. Ronald KM. Woodward JJ. 1998 Intracellular calcium enhances the ethanol sensitivity of NMDA receptors through an interaction with the C0 domain of the NR1 subunit JNeurochem 71 1095 1107
21. Miyakawa T. Yagi T. Kitazawa H. Yasuda M. Kawai N. Tsuboi K. Niki H. 1997 Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function Science 278 698 701
22. Scott DB. Blanpied TA. Swanson GT. Zhang C. Ehlers MD. 2001 An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing JNeurosci 21 3063 3072
23. Scott DB. Blanpied TA. Ehlers MD. 2003 Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors Neuropharmacology 45 755 767
24. Simson PE. Criswell HE. Breese GR. 1993 Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses Brain Res 607 9 16
25. Tingley WG. Ehlers MD. Kameyama K. Doherty C. Ptak JB. Riley CT. Huganir RL. 1997 Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl- d -aspartate receptor NR1 subunit using phosphorylation site-specific antibodies JBiolChem 272 5157 5166
26. Valenzuela CF. Cardoso RA. Lickteig R. Browning MD. Nixon KM. 1998 Acute effects of ethanol on recombinant kainate receptors: lack of role of protein phosphorylation AlcoholClinExpRes 22 1292 1299
27. A receptor expressed in Xenopus oocytes requires eight amino acids contained in the γ2L subunit Neuron 7 27 33
28. Westphal RS. Tavalin SJ. Lin JW. Alto NM. Fraser IDC. Langeberg LK. Sheng M. Scott JD. 1999 Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex Science 285 93 96
29. Woodward JJ. 2000 Ethanol and NMDA receptor signaling CritRevNeurobiol 14 69 89
30. 2A-containing N-methyl- d -aspartate receptors Alcohol 34 101 105
31. 2A mutant Alcohol 31 71 76
32. Xia H. Hornby ZD. Malenka RC. 2001 An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits Neuropharmacology 41 714 723
33. Yaka R. Phamluong K. Ron D. 2003 Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol JNeurosci 23 3623 3632
34. 1-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens Synapse 58 30 44