Fyn kinase does not reduce ethanol inhibition of zinc-insensitive NR2A-containing N-methyl-D-aspartate receptors

Alcohol

Volumn 34, Issue 2-3, 2004, Pages 101-105

  Woodward, John J ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

bpV(phen); Electrophysiology; Phosphorylation; Tyrosine kinase

Indexed keywords

ALCOHOL; CHELATING AGENT; GLUTAMIC ACID; HEAVY METAL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PHENANTHROLINE DERIVATIVE; POTASSIUM BISPEROXO(1,10 PHENANTHROLINE)OXOVANADATE; PROTEIN KINASE FYN; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CELL LINE; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PATCH CLAMP; SENSITIVITY ANALYSIS;

EID: 14544307453     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2004.11.003     Document Type: Article

References (20)

1. R.M. Alvestad, D.R. Grosshans, S.J. Coultrap, T. Nakazawa, T. Yamamoto, and M.D. Browning Tyrosine dephosphorylation and ethanol inhibition of N-methyl-d-aspartate receptor function J Biol Chem 278 2003 11020 11025
2. D.L. Anders, T. Blevins, G. Sutton, S. Swope, L.J. Chandler, and J.J. Woodward Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells J Neurochem 72 1999 1389 1393
3. T. Blevins, T. Mirshahi, L.J. Chandler, and J.J. Woodward Effects of acute and chronic ethanol exposure on heteromeric N-methyl-d-aspartate receptors expressed in HEK 293 cells J Neurochem 69 1997 2345 2354
4. B. Chu, V. Anantharam, and S.N. Treistman Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators J Neurochem 65 1995 140 148
5. 2+ binding to NMDA receptors Neuron 25 2000 683 694
6. H.-F. Li, and J.J. Kendig Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neurons Br J Pharmacol 139 2003 73 80
7. K. Masood, C. Wu, U. Brauneis, and F.F. Weight Differential ethanol sensitivity of recombinant N-methyl-d-aspartate receptor subunits Mol Pharmacol 45 1994 324 329
8. T. Mirshahi, D.L. Anders, K.M. Ronald, and J.J. Woodward Intracellular calcium enhances the ethanol sensitivity of NMDA receptors through an interaction with the C0 domain of the NR1 subunit J Neurochem 71 1998 1095 1107
9. 2+-insensitive mutants Neuropharmacology 34 1995 347 355
10. T. Miyakawa, T. Yagi, H. Kitazawa, M. Yasuda, N. Kawai, K. Tsuboi, and H. Niki Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function Science 278 1997 698 701
11. P. Paoletti, P. Ascher, and J. Neyton High-affinity zinc inhibition of NMDA NR1-NR2A receptors J Neurosci 17 1997 5711 5725
12. H. Ren, Y. Honse, and R.W. Peoples A site of alcohol action in the fourth membrane-associated domain of the N-methyl-d-aspartate receptor J Biol Chem 278 2003 48815 48820
13. K.M. Ronald, T. Mirshahi, and J.J. Woodward Ethanol inhibition of N-methyl-d-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue J Biol Chem 276 2001 44729 44735
14. V.A. Skeberdis, J.-y. Lan, X. Zheng, R.S. Zukin, and M.V.L. Bennett Insulin promotes rapid delivery of N-methyl-d-aspartate receptors to the cell surface by exocytosis Proc Natl Acad Sci U S A 98 2001 3561 3566
15. Y.T. Wang, and M.W. Salter Regulation of NMDA receptors by tyrosine kinases and phosphatases Nature 369 1994 233 235
16. J.J. Woodward Ethanol and NMDA receptor signaling Crit Rev Neurobiol 14 2000 69 89
17. J.J. Woodward, and C. Smothers Ethanol inhibition of recombinant NR1/2A receptors: effects of heavy metal chelators and a zinc-insensitive NR2A mutant Alcohol 31 2003 71 76
18. R. Yaka, K. Phamluong, and D. Ron Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol J Neurosci 23 2003 3623 3632
19. R. Yaka, C. Thornton, A.J. Vagts, K. Phamluong, A. Bonci, and D. Ron NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1 Proc Natl Acad Sci U S A 99 2002 5710 5715
20. F. Zheng, M.B. Gingrich, S.F. Traynelis, and P.J. Conn Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition Nat Neurosci 1 1998 185 191