Does severity of low-dose, double-blind, placebo-controlled food challenges reflect severity of allergic reactions to peanut in the community?

Clinical and Experimental Allergy

Volumn 35, Issue 9, 2005, Pages 1227-1233

  Hourihane, J O'B ^a,b,d   Grimshaw, K E C ^a,b   Lewis, S A ^a   Briggs, R A ^a   Trewin, J B ^b   King, R M ^b   Kilburn, S A ^c   Warner, J O ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^d UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Anaphylaxis; Double blind; Food allergy; Peanut; Placebo controlled food challenge; Threshold

Indexed keywords

PLACEBO; BIOLOGICAL MARKER; IMMUNOGLOBULIN E;

ADOLESCENT; ADULT; ANAPHYLAXIS; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; FOOD ALLERGY; FOOD CHALLENGE; HUMAN; MALE; PEANUT; PEANUT ALLERGY; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; QUESTIONNAIRE; SCORING SYSTEM; URTICARIA; ASTHMA; BLOOD; CROSS-SECTIONAL STUDY; ECZEMA; IMMUNOLOGY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PREDICTION AND FORECASTING; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SKIN TEST;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ARACHIS HYPOGAEA; ASTHMA; BIOLOGICAL MARKERS; CHILD; CROSS-SECTIONAL STUDIES; DOUBLE-BLIND METHOD; ECZEMA; FEMALE; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; PEANUT HYPERSENSITIVITY; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SKIN TESTS;

EID: 33644792803     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02312.x     Document Type: Article

References (30)

1. Sampson HA. Update on food allergy. J Allergy Clin Immunol 2004 113 : 805 19.
2. Bindslev-Jensen C Ballmer-Weber BK Bengtsson U et al. Standardization of food challenges in patients with immediate reactions to foods - position paper from the european academy of allergology and clinical immunology. Allergy 2004 59 : 690 7.
3. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001 107 : 891 6.
4. Eigenmann PA Sampson HA. Interpreting skin prick tests in the evaluation of food allergy in children. Pediatr Allergy Immunol 1998 9 : 186 91.
5. Sporik R Hill DJ Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy 2000 30 : 1540 6.
6. Hill DJ Hosking CS Reyes-Benito LV. Reducing the need for food allergen challenges in young children: a comparison of in vitro with in vivo tests. Clin Exp Allergy 2001 31 : 1031 5.
7. Hourihane JO Kilburn SA Dean P Warner JO. Clinical characteristics of peanut allergy. Clin Exp Allergy 1997 27 : 634 9.
8. Hourihane JO'B Kilburn SA Nordlee JA Hefle SL Taylor SL Warner JO. An evaluation of the sensitivity of peanut allergic subjects to very low doses of peanut protein: a randomised, double-blind, placebo-controlled food challenge study. J Allergy Clin Immunol 1997 100 : 596 600.
9. van Odijk J Ahlstedt S Bengtsson U Hulthen L Borres MP. Specific IgE antibodies to peanut in western Sweden - has the occurrence of peanut allergy increased without an increase in consumption? Allergy 2001 56 : 573 7.
10. Clark AT Ewan PE. Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance. Clin Exp Allergy 2003 33 : 1041 5.
11. Vander Leek TK Liu AH Stefanski K Blacker B Bock SA. The natural history of peanut allergy in young children and its association with serum peanut-specific IgE. J Pediatr 2000 137 : 749 55.
12. Skolnick HS Conover-Walker MK Barnes Koerner C Sampson HA Burks AW Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol 2001 107 : 367 74.
13. Fleischer DM Conover-Walker MK Christie L Burks AW Wood RA. The natural progression of peanut allergy: resolution and the possibility of recurrence. J Allergy Clin Immunol 2003 112 : 183 9.
14. Wensing M Penninks AH Hefle SL Koppelman SJ Bruijnzeel-Koomen CA Knulst AC. The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy. J Allergy Clin Immunol 2002 110 : 915 20.
15. Osterballe M Bindslev-Jensen C. Threshold levels in food challenge and specific IgE in patients with egg allergy: is there a relationship? J Allergy Clin Immunol 2003 112 : 196 201.
16. Taylor SL Hefle SL Bindlev Jensen C et al. Factors affecting the determination of threshold doses for allergenic foods: how much is too much? J Allergy Clin Immunol 2002 109 : 24 30.
17. Taylor SL Hefle SL Bindslev Jensen C et al. A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much? Clin Exp Allergy 2004 34 : 689 95.
18. Furlong TJ DeSimone J Sicherer SH. Peanut and tree nut allergic reactions in restaurants and other food establishments. J Allergy Clin Immunol 2001 108 : 867 70.
19. Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000 30 : 1144 50.
20. Bock SA Munoz-Furlong A Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001 107 : 191 3.
21. Sampson HA Mendelson L Rosen J. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992 327 : 380 4.
22. MacDougall CF Cant AJ Colver AF. How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child 2002 86 : 236 9.
23. Roberts G Patel N Levi-Schaffer F Habibi P Lack G. Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. J Allergy Clin Immunol 2003 112 : 168 74.
24. Muller UR. Insect sting allergy, clinical diagnosis and treatment. Stuttgart, Gustav Fischer, 1990.
25. Ewan PW Clark AT. Long-term prospective observational study of patients with peanut and nut allergy after participation in a management plan. Lancet 2001 357 : 111 5.
26. Hourihane JO'B Bedwani SJ Dean TP Warner JO. Randomised, double-blind, crossover challenge study of allergenicity of peanut oils in subjects allergic to peanuts. Br Med J 1997 314 : 1084 8.
27. Bock SA Sampson HA Atkins FM et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988 82 : 986 97.
28. Grimshaw KEC King RM Nordlee JA Hefle SL Warner JO Hourihane JO'B. Presentation of allergen in different food preparations affects the severity of the allergic reaction - a case series. Clin Exp Allergy 2003 33 : 1581 5.
29. Morisset M Moneret-Vautrin DA Kanny G et al. Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenges. Clin Exp Allergy 2003 33 : 1046 51.
30. van der Zee JA Wensing M Penninks AH Bruijnzeel-Koomen CAF Knulst AC. Threshold levels in peanut and hazel nut allergic patients do not change over time. Proceedings of XXII Congress of European Academy of Allergology and Clinical Immunology, Paris, 2003.