An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: A randomized, double-blind, placebo-controlled food challenge study

Journal of Allergy and Clinical Immunology

Volumn 100, Issue 5, 1997, Pages 596-600

  Hourihane, Jonathan O 'B ^a,c   Kilburn, Sally A ^a   Nordlee, Julie A ^b   Hefle, Susan L ^b   Taylor, Steve L ^b   Warner, John O ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Food challenge; Low dose; Peanut allergy

Indexed keywords

ADOLESCENT; ADULT; ALLERGENICITY; ALLERGY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; FOOD ALLERGY; HUMAN; MALE; PEANUT; PRIORITY JOURNAL; PROTEIN INTAKE; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL;

EID: 0030658943     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70161-1     Document Type: Article

References (23)

1. Ewan P. Clinical study of peanut and nut allergy in 62 consecutive patients: new features and associations. BMJ 1996;312:1074-8.
2. Hourihane JO'B, Dean TP, Warner JO. Peanut allergy in relation to heredity, maternal diet and other atopic diseases: results of a questionnaire survey, skin prick testing and food challenges. BMJ 1996;313:518-21.
3. Yunginger JW, Sweeney KG, Sturner WQ, Giannandrea LA. Teigland JD, Bray M, et al. Fatal food-induced anaphylaxis. JAMA 1988;260:1450-2.
4. Sampson HA, Mendelson L, Rosen JP. Fatal and near fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992;327:380-4.
5. Hourihane JO'B, Kilburn SA, Dean TP, Warner JO. Clinical characteristics of peanut allergy. Clin Exp Allergy 1997;27:634-9.
6. Bock SA, Atkins FM. The natural history of peanut allergy. J Allergy Clin Immunol 1989;83:900-4.
7. Burks AW, Williams LW, Thresher W, Connaughton C, Cockrell G, Helm RM. Allergenicity of peanut and soybean extracts altered by chemical or thermal denaturation in patients with atopic dermatitis and positive food challenges. J Allergy Clin Immunol 1992;90:889-97.
8. Nordlee JA, Taylor SL, Jones RT, Yunginger JW. Allergenicity of various peanut products as determined by RAST inhibition. J Allergy Clin Immunol 1981;68:376-82.
9. Fries JH. Peanuts: allergic and other untoward reactions. Ann Allergy 1982;48:220-6.
10. Dawe RS, Ferguson J. Allergy to peanut [letter]. Lancet 1996;348:1522.
11. Hoffman DR, Collins-Williams C. Cold-pressed peanut oils may contain peanut allergen. J Allergy Clin Immunol 1994;93:801-2.
12. Hourihane JO'B, Bedwani SJ, Dean TP, Warner JO. Randomised, double-blind, crossover challenge study of allergenicity of peanut oils in subjects allergic to peanuts. BMJ 1997;314:1084-8.
13. Bock SA, Sampson HA, Atkins FM, Zeiger RS, Lehrer S, Sachs M, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988;82:986-97.
14. Atkins FM, Wilson M, Bock SA. Cottonseed hypersensitivity: new concerns over an old problem. J Allergy Clin Immunol 1988;82:242-50.
15. Sampson HA. Peanut anaphylaxis [editorial]. J Allergy Clin Immunol 1990;86:1-3.
16. Magnolfi CF, Lacava L, Patria MF, Bardare M. Soy allergy in atopic children. Ann Allergy Asthma Immunol 1996;77:197-201.
17. Amlott PL, Kemeny DM, Zachary C, Parkes P, Lessof MH. Oral allergy syndrome (OAS); symptoms of IgE-mediated hypersensitivity to foods. Clinical Allergy 1987;17:33-4.
18. Hamilos DL, Oppenheimer JJ, Nelson HS, Wenzel S, Driscoll S, Lockey RF, et al. Suggested approaches for research protocols involving the potential for life-threatening reactions. J Allergy Clin Immunol 1993;91:1101-21.
19. Cunniffe P, editor. Official methods of analysis of AOAC international. 16th ed. Arlington (VA): AOAC International; 1995. Chapter 32, p. 23; and chapter 39, p. 7.
20. Niggemann B, Wahn U, Sampson HA. Proposals for standardisation of oral food challenge tests in infants and children. Pediatr Allergy Immunol 1994;5:11-3.
21. Sampson HA. Managing peanut allergy [editorial]. BMJ 1996;312: 1050-1.
22. Taylor SL, Busse WW, Sachs MI, Parker JL, Yunginger JW. Peanut oil is not allergenic to peanut-sensitive individuals. J Allergy Clin Immunol 1981;68:372-5.
23. Yunginger JW, Gauerke MB, Jones RT, Dahlberg MJE, Ackerman SJ. Use of radioimmunoassay to determine the nature, quantity and source of allergenic contamination of sunflower butter. J Food Protection 1983;46:625-8.