Identification of novel neuronal isoforms of the Rho-GEF Trio

Biology of the Cell

Volumn 98, Issue 3, 2006, Pages 183-193

  Portales Casamar, Elodie ^a   Briançon Marjollet, Anne ^a   Fromont, Sylvie ^a   Triboulet, Robinson ^a   Debant, Anne ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

Alternative splicing; Guanine nucleotide exchange factor (GEF); Neurite outgrowth; Rho GTPase; Trio

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; RHO FACTOR; RHO GUANOSINE TRIPHOSPHATASE;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA, COMPLEMENTARY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEURONS; PC12 CELLS; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; RATS; RHO GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 33644772219     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1042/BC20050009     Document Type: Article

References (26)

1. Alam, M.R., Johnson, R.C., Darlington, D.N., Hand, T.A., Mains, R.E. and Eipper, B.A. (1997) Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. J. Biol. Chem. 272, 12667-12675
2. Awasaki, T., Saito, M., Sone, M., Suzuki, E., Sakai, R., Ito, K. and Hama, C. (2000) The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension. Neuron 26, 119-131
3. Bateman, J. and Van Vactor, D. (2001) The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance. J. Cell Sci. 114, 1973-1980
4. Bateman, J., Shu, H. and Van Vactor, D. (2000) The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron 26, 93-106
5. Bellanger, J.M., Lazaro, J.B., Diriong, S., Fernandez, A., Lamb, N. and Debant, A. (1998) The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Oncogene 16, 147-152
6. Bellanger, J.M., Estrach, S., Schmidt, S., Briancon-Marjollet, A., Zugasti, O., Fromont, S. and Debant, A. (2003) Different regulation of the Trio Dbl-Homology domains by their associated PH domains. Biol. Cell 95, 625-634
7. Blangy, A., Vignal, E., Schmidt, S., Debant, A., Gauthier-Rouviere, C. and Fort, P. (2000) TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG. J. Cell Sci. 113, 729-739
8. Debant, A., Serra-Pages, C., Seipel, K., O'Brien, S., Tang, M., Park, S.H. and Streuli, M. (1996) The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl. Acad. Sci. U.S.A. 93, 5466-5471
9. Dickson, B.J. (2001) Rho GTPases in growth cone guidance. Curr. Opin. Neurobiol. 11, 103-110
10. Estrach, S., Schmidt, S., Diriong, S., Penna, A., Blangy, A., Fort, P. and Debant, A. (2002) The human Rho-GEF Trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth. Curr. Biol. 12, 307-312
11. Etienne-Manneville, S. and Hall, A. (2002) Rho GTPases in cell biology. Nature (London) 420, 629-635
12. Gauthier-Rouviere, C., Vignal, E., Meriane, M., Roux, P., Montcourier, P. and Fort, P. (1998) RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs. Mol. Biol. Cell 9, 1379-1394
13. Goldschneider, D., Blanc, E., Raguenez, G., Barrois, M., Legrand, A., Le Roux, G., Haddada, H., Benard, J. and Douc-Rasy, S. (2004) Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line. J. Cell Sci. 117, 293-301
14. Johnson, R.C., Penzes, P., Eipper, B.A. and Mains, R.E. (2000) Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5′- and 3′-ends along with an internal translational initiation site. J. Biol. Chem. 275, 19324-19333
15. Kawai, T., Sanjo, H. and Akira, S. (1999) Duet is a novel serine/ threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene 227, 249-255
16. Li, X., Saint-Cyr-Proulx, E., Aktories, K. and Lamarche-Vane, N. (2002) Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277, 15207-15214
17. May, V., Schiller, M.R., Eipper, B.A. and Mains, R.E. (2002) Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms. J. Neurosci. 22, 6980-6990
18. McPherson, C.E., Eipper, B.A. and Mains, R.E. (2002) Genomic organization and differential expression of Kalirin isoforms. Gene 284, 41-51
19. Newsome, T.P., Schmidt, S., Dietzl, G., Keleman, K., Asling, B., Debant, A. and Dickson, B.J. (2000) Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101, 283-294
20. O'Brien, S.P., Seipel, K., Medley, Q.G., Bronson, R., Segal, R. and Streuli, M. (2000) Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. Proc. Natl. Acad. Sci. U.S.A. 97, 12074-12078
21. Penzes, P., Johnson, R.C., Kambampati, V., Mains, R.E. and Eipper, B.A. (2001) Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology. J. Neurosci. 21, 8426-8434
22. Penzes, P., Beeser, A., Chernoff, J., Schiller, M.R., Eipper, B.A., Mains, R.E. and Huganir, R.L. (2003) Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 37, 263-274
23. Schmidt, A. and Hall, A. (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 16, 1587-1609
24. Steven, R., Kubiseski, T.J., Zheng, H., Kulkarni, S., Mancillas, J., Ruiz Morales, A., Hogue, C.W., Pawson, T. and Culotti, J. (1998) UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795
25. Taviaux, S., Diriong, S., Bellanger, J.M., Streuli, M. and Debant, A. (1997) Assignment of TRIO, the Trio gene (PTPRF interacting) to human chromosome bands 5p 15.1 → p 14 by in situ hybridization. Cytogenet. Cell. Genet. 76, 107-108
26. Yoshizuka, N., Moriuchi, R., Mori, T., Yamada, K., Hasegawa, S., Maeda, T., Shimada, T., Yamada, Y., Kamihira, S., Tomonaga, M. and Katamine, S. (2004) An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential. J. Biol. Chem. 279, 43998-44004