Causal role of Helicobacter pylori infection in gastric cancer

World Journal of Gastroenterology

Volumn 12, Issue 2, 2006, Pages 181-186

  Ando, Takafumi ^a   Goto, Yasuyuki ^a   Maeda, Osamu ^a   Watanabe, Osamu ^a   Ishiguro, Kazuhiro ^a   Goto, Hidemi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bacterial virulence factors; Gastric cancer; H pylori; Host genetic factors

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; CAGA PROTEIN; CLARITHROMYCIN; CYTOKINE; METRONIDAZOLE; OMEPRAZOLE; PLACEBO;

ASIA; ATROPHIC GASTRITIS; BACTERIAL VIRULENCE; CANCER PREVENTION; CANCER RISK; CANCER SCREENING; CLINICAL PROTOCOL; CLINICAL TRIAL; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA POLYMORPHISM; EDITORIAL; ENVIRONMENTAL FACTOR; ERADICATION THERAPY; EUROPE; FOLLOW UP; GASTRECTOMY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HEREDITY; HUMAN; LIFESTYLE; MORBIDITY; MORTALITY; NONHUMAN; SOUTH AND CENTRAL AMERICA; STOMACH CANCER; STOMACH CARCINOGENESIS;

EID: 33644763308     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i2.181     Document Type: Editorial

References (88)

1. Feldman RA, Eccersley AJ, Hardie JM. Epidemiology of H pylori: acquisition, transmission, population prevalence and disease-to-infection ratio. Br Med Bull 1998; 54: 39-53
2. Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI, Blaser MJ. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 1989; 321: 1562-1566
3. Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T, Miki K, Graham DY. Relationship of H pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 1992; 102: 760-766
4. Youn HS, Ko CH, Chung MH, Lee WK, Cho MJ, Rhee KH. Pathogenesis and prevention of stomach cancer. J Korean Med Sci 1996; 11: 373-385
5. Sipponen P, Marshall BJ. Gastritis and gastric cancer. Western countries. Gastroenterol Clin North Am 2000; 29: 579-592 v-vi
6. Plummer M, Franceschi S, Munoz N. Epidemiology of gastric cancer. IARC Sci Publ 2004; 311-326
7. Peterson WL, Graham DY. H pylori. In: Feldman M, Scharschmidt BF, Sleisenger MH editors Gastrointestinal and liver Disease. Pathophysiology, diagnosis, management. 6th ed. Philadelphia: WB saundes 1998; 604-619
8. Cave DR. Chronic gastritis and H pylori. Semin Gastrointest Dis 2001; 12:196-202
9. Cohen H. Peptic ulcer and H pylori. Gastroenterol Clin North Am 2000; 29: 775-789
10. Xue FB, Xu YY, Wan Y, Pan BR, Ren J, Fan DM. Association of H pylori infection with gastric carcinoma: a Meta analysis. World J Gastroenterol 2001; 7: 801-804
11. Infection with Helicobactor pylori. In: IARC monographs on the evaluation of the carcinogenic risks to humans. Vol. 61. Schistosomes, liver flukes, and Helicobactor pylori. Lyon, France: International Agency for Research on Cancer 1994: 177-241
12. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A. Infection with H pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995; 55: 2111-2115
13. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF Jr, Rabkin CS. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398-402
14. El-Omar EM, Chow WH, Rabkin CS. Gastric cancer and H. pylori: Host genetics open the way. Gastroenterology 2001; 121: 1002-1004
15. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF Jr, Chow WH. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124: 1193-1201
16. Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Simoes M. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 2001; 121: 823-829
17. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Castro Alves C, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Simoes M. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003; 125:364-371
18. Yamaoka Y, El-Zimaity HM, Gutierrez O, Figura N, Kim JG, Kodama T, Kashima K, Graham DY. Relationship between the cagA 3' repeat region of H pylori, gastric histology, and susceptibility to low pH. Gastroenterology 1999; 117.342-349
19. Azuma T, Yamazaki S, Yamakawa A, Ohtani M, Muramatsu A, Suto H, Ito Y, Dojo M, Yamazaki Y, Kuriyama M, Keida Y, Higashi H, Hatakeyama M. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of H pylori CagA protein and gastric atrophy and cancer. J Infect Dis 2004; 189: 820-827
20. Whiting JL, Hallissey MT, Fielding JW, Dunn J. Screening for gastric cancer by H pylori serology: a retrospective study. Br J Surg 1998; 85: 408-411
21. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996; 20:1161-1181
22. Cerutti PA. Prooxidant states and tumor promotion. Science 1985; 227: 375-381
23. Tamir S, Tannenbaum SR. The role of nitric oxide (NO.) in the carcinogenic process. Biochim Biophys Acta 1996; 1288: F31-F36
24. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ. H pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784-789
25. Eslick GD, Lim LL, Byles JE, Xia HH, Talley NJ. Association of H pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol 1999; 94: 2373-2379
26. Wang RT, Wang T, Chen K, Wang JY, Zhang JP, Lin SR, Zhu YM, Zhang WM, Cao YX, Zhu CW, Yu H, Cong YJ, Zheng S, Wu BQ. H pylori infection and gastric cancer: evidence from a retrospective cohort study and nested case-control study in China. World J Gastroenterol 2002; 8: 1103-1107
27. Caputo S, Mosca F, Persi A, Ettaro G, Scaringi S, Russo G, Piazza D. [H pylori and gastric cancer. The incidence of infection in personal experience] Minerva Chir 2002; 57: 649-655
28. Khanna AK, Seth P, Nath G, Dixit M Kumar M. Correlation of H pylori and gastric carcinoma. J Postgrad Med 2002; 48: 27-28
29. Enroth H, Kraaz W, Rohan T, Nyren O, Engstrand L. Does the method of H pylori detection influence the association with gastric cancer risk? Scand J Gastroenterol 2002; 37: 884-890
30. Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter 2001; 6: 294-299
31. Kikuchi S, Crabtree JE, Forman D, Kurosawa M. Association between infections with CagA-positive or-negative strains of H pylori and risk for gastric cancer in young adults. Research Group on Prevention of Gastric Carcinoma Among Young Adults. Am J Gastroenterol 1999; 94: 3455-3459
32. Parsonnet J, Friedman CD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative H pylori infection. Gut 1997; 40: 297-301
33. Brenner H, Arndt V, Sturmer T, Stegmaier C, Ziegler H, Dhom G. Individual and joint contribution of family history and H pylori infection to the risk of gastric carcinoma. Cancer 2000; 88: 274-279
34. Shimoyama T, Fukuda S, Tanaka M, Mikami T, Munakata A, Crabtree JE. CagA seropositivity associated with development of gastric cancer in a Japanese population. J Clin Pathol 1998; 51: 225-228
35. Ekstrom AM, Held M, Hansson LE, Engstrand L, Nyren O. H pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology 2001; 121: 784-791
36. Maeda S, Yoshida H, Ogura K, Yamaji Y, Ikenoue T, Mitsushima T, Tagawa H, Kawaguchi R, Mori K, Mafune K, Kawabe T, Shiratori Y, Omata M. Assessment of gastric carcinoma risk associated with H pylori may vary depending on the antigen used: CagA specific enzyme-linked immunoadsorbent assay (ELISA) versus commercially available H. pylori ELISAs. Cancer 2000; 88: 1530-1535
37. Ando T, Peek RM Jr, Lee YC, Krishna U, Kusugami K, Blaser MJ. Host cell responses to genotypically similar H pylori isolates from United States and Japan. Clin Diagn Lab Immunol 2002; 9:167-175
38. Held M, Engstrand L, Hansson LE, Bergstrom R, Wadstrom T, Nyren O. Is the association between H pylori and gastric cancer confined to CagA-positive strains? Helicobacter 2004; 9: 271-277
39. Ando T, Perez-Perez GI, Kusugami K, Ohsuga M, Bloch KC, Blaser MJ. Anti-CagA immunoglobulin G responses correlate with interleukin-8 induction in human gastric mucosal biopsy culture. Clin Diagn Lab Immunol 2000; 7: 803-809
40. Tatemichi M, Hamada GS, Nishimoto IN, Kowalski LP, Iriya K, Rodrigues JJ, Tsugane S. Ethnic difference in serology of H pylori CagA between Japanese and non-Japanese Brazilians for non-cardia gastric cancer. Cancer Sci 2003; 94: 64-69
41. Huang JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 2003; 125: 1636-1644
42. Sorberg M, Engstrand L, Strom M, Jonsson KA, Jorbeck H, Granstrom M. The diagnostic value of enzyme immunoassay and immunoblot in monitoring eradication of H pylori. Scand J Infect Dis 1997; 29: 147-151
43. Klaamas K, Held M, Wadstrom T, Lipping A, Kurtenkov O. IgG immune response to H pylori antigens in patients with gastric cancer as defined by ELISA and immunoblotting. Int J Cancer 1996; 67: 1-5
44. Rudi J, Kolb C, Maiwald M, Zuna I, von Herbay A, Galle PR, Stremmel W. Serum antibodies against H pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma. Dig Dis Sci 1997; 42: 1652-1659
45. Asahi M, Azuma T, Ito S, Ito Y, Suto H, Nagai Y, Tsubokawa M, Tohyama Y, Maeda S, Omata M, Suzuki T, Sasakawa C. H pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 2000; 191: 593-602
46. Stein M, Rappuoli R, Covacci A. Tyrosine phosphorylation of the H pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci USA 2000; 97: 1263-1268
47. Segal ED, Cha J, Lo J, Falkow S, Tompkins LS. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by H pylori. Proc Natl Acad Sci USA 1999; 96: 14559-14564
48. Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of H pylori CagA into gastric epithelial cells by type IV secretion. Science 2000; 287: 1497-1500
49. Neel BG, Gu H, Pao L. The 'Shp'ing news: SH2 domaincontaining tyrosine phosphatases in cell signaling. Trends Biochem Sci 2003; 28: 284-293
50. Tartaglia M, Niemeyer CM, Shannon KM, Loh ML. SHP-2 and myeloid malignancies. Curr Opin Hematol 2004; 11: 44-50
51. Tang TL, Freeman RM Jr. O'Reilly AM, Neel BG, Sokol SY. The SH2-containing protein-tyrosine phosphatase SHPTP2 is required upstream of MAP kinase for early Xenopus development. Cell 1995; 80: 473-483
52. Azuma T, Yamazaki S, Yamakawa A, Ohtani M, Muramatsu A, Suto H, Ito Y, Dojo M, Yamazaki Y, Kuriyama M, Keida Y, Higashi H, Hatakeyama M. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of H pylori CagA protein and gastric atrophy and cancer. J Infect Dis 2004; 189: 820-827
53. Goto Y, Ando T, Yamamoto K, Tamakoshi A, El-Omar E, Goto H, Hamajima N. Association between serum pepsinogens and polymorphism of PTPN11 encoding SHP-2 among H pylori seropositive Japanese. Int J Cancer 2006; 189: 820-827
54. Mimuro H, Suzuki T, Tanaka J, Asahi M, Haas R, Sasakawa C. Grb2 is a key mediator of H pylori CagA protein activities. Mol Cell 2002; 10: 745-755
55. Selbach M, Moese S, Hurwitz R, Hauck CR, Meyer TF, Backert S. The H pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J 2003; 22: 515-528
56. Zambon CF, Basso D, Navaglia F, Germano G, Gallo N, Milazzo M, Greco E, Fogar P, Mazza S. Di Mario F, Basso G, Rugge M, Plebani M. H pylori virulence genes and host IL-1RN and IL-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia. Cytokine 2002; 18: 242-251
57. Basso D, Scrigner M, Toma A, Navaglia F, Di Mario F, Rugge M, Plebani M. H pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2. Int J Clin Lab Res 1996; 26:207-210
58. Lindholm C, Quiding-Jarbrink M, Lonroth H, Hamlet A, Svennerholm AM. Local cytokine response in H pylori-infected subjects. Infect Immun 1998; 66:5964-5971
59. Holck S, Norgaard A, Bennedsen M, Permin H, Norn S, Andersen LP. Gastric mucosal cytokine responses in H pylori-infected patients with gastritis and peptic ulcers. Association with inflammatory parameters and bacteria load. FEMS Immunol Med Microbiol 2003; 36:175-180
60. Bontems P, Robert F, Van Cossum A, Cadranel S, Mascart F. H pylori modulation of gastric and duodenal mucosal T cell cytokine secretions in children compared with adults. Helicobacter 2003; 8: 216-996
61. Ando T, Kusugami K, Ohsuga M, Shinoda M, Sakakibara M, Saito H, Fukatsu A, Ichiyama S, Ohta M. Interleukin-8 activity correlates with histological severity in H pylori-associated antral gastritis. Am J Gastroenterol 1996; 91: 1150-1156
62. Ando T, Kusugami K, Ohsuga M, Ina K, Shinoda M, Konagaya T, Sakai T, Imada A, Kasuga N, Nada T, Ichiyama S, Blaser MJ. Differential normalization of mucosal interleukin-8 and interleukin-6 activity after H pylori eradication. Infect Immun 1998; 66: 4742-4747
63. Ando T, Kusugami K, Ohsuga M, Ina K, Ichiyama S, Nada T, Ohta M. Mucosal macrophage inflammatory protein-1alpha levels are increased in H pylori infection. J Clin Gastroenterol 1998; 27 Suppl 1: S144-S149
64. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-Simoes M. H pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002; 94: 1680-1687
65. El-Omar EM. The importance of interleukin 1beta in H pylori associated disease. Gut 2001; 48: 743-747
66. Beales IL, Calam. J. Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut 1998; 42: 277-234
67. Hamajima N, Matsuo K, Saito T, Tajima K, Okuma K, Yamao K, Tominaga S. Interleukin 1 polymorphisms, lifestyle factors, and H pylori infection. Jpn J Cancer Res 2001; 92: 383-389
68. Hwang IR, Kodama T, Kikuchi S, Sakai K, Peterson LE, Graham DY, Yamaoka Y. Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in H pylori infection. Gastroenterology 2002; 123: 1793-1803
69. Rad R, Dossumbekova A, Neu B, Lang R, Bauer S, Saur D, Gerhard M, Prinz C. Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during H pylori infection. Gut 2004; 53: 1082-1089
70. Zambon CF, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, Greco E, Gallo N, Rugge M, Di Mario F, Plebani M. Pro-and anti-inflammatory cytokines gene polymorphisms and H pylori infection: interactions influence outcome. Cytokine 2005; 29: 141-152
71. Kato S, Onda M, Yamada S, Matsuda N, Tokunaga A, Matsukura N. Association of the interleukin-1 beta genetic polymorphism and gastric cancer risk in Japanese. J Gastroenterol 2001; 36: 696-699
72. Lee KA, Ki CS, Kim HJ, Sohn KM, Kim JW, Kang WK, Rhee JC, Song SY, Sohn TS. Novel interleukin 1beta polymorphism increased the risk of gastric cancer in a Korean population. J Gastroenterol 2004; 39: 429-433
73. World Health Organization. Diet, nutrition, and the prevention of chronic diseases. WHO technical report series 916. Geneva: World Health Organization, 2003
74. World Cancer Reserch fund, American Institute for cancer Reserch. Food, nutrition and the prevention of cancer: a global perspective. Washington: American Institute for Cancer Reserch, 1997.
75. Kono S, Hirohata T. Nutrition and stomach cancer. Cancer Causes Control 1996; 7: 41-55
76. International Agency for Research on Cancer. Tobacco smoking and Tobacco smoke. IARC Monographs on the evaluation of the carcinogenic risks to Humans, 83. Lyon: International Agency for Research on Cancer, 2004
77. Tsugane S, Tei Y, Takahashi T, Watanabe S, Sugano K. Salty food intake and risk of H pylori infection. Jpn J Cancer Res 1994; 85: 474-478
78. Nozaki K, Shimizu N, Inada K, Tsukamoto T, Inoue M, Kumagai T, Sugiyama A, Mizoshita T, Kaminishi M, Tatematsu M. Synergistic promoting effects of H pylori infection and high-salt diet on gastric carcinogenesis in Mongolian gerbils. Jpn J Cancer Res 2002; 93: 1083-1089
79. Lee SA, Kang D, Shim KN, Choe JW, Hong WS, Choi H. Effect of diet and H pylori infection to the risk of early gastric cancer. J Epidemiol 2003; 13: 162-168
80. Machida-Montani A, Sasazuki S, Inoue M, Natsukawa S, Shaura K, Koizurni Y, Kasuga Y, Hanaoka T, Tsugane S. Association of H pylori infection and environmental factors in non-cardia gastric cancer in Japan. Gastric Cancer 2004; 7: 46-53
81. Wong BC, Lam SK, Wong WM, Chen JS, Zlieng TT, Feng RE, Lai KC, Hu WH, Yuen ST, Leung SY, Fong DY, Ho J, Ching CK, Chen JS. H pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 2004; 291:187-194
82. Leung WK, Lin SR, Ching JY, To KF, Ng EK, Chan FK, Lau JY, Sung JJ. Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on H pylori eradication. Gut 2004; 53: 1244-1249
83. Ley C, Mohar A, Guarner J, Herrera-Goepfert R, Figueroa LS, Halperin D, Johnstone I, Parsonnet J. H pylori eradication and gastric preneoplastic conditions: a randomized, double-blind, placebo-controlled trial. Cancer Epidemiol Biomarkers Prev 2004; 13: 14-10
84. Langhans P, Bues M, Bunte H. Morphological changes in the operated stomach under the influence of duodenogastric reflux. Clinical follow-up over 20 years. Scand J Gastroenterol Suppl 1984; 92: 145-148
85. Weinstein WM, Buch KL, Elashoff J, Reedy T, Tedesco FJ, Samloff IM, Ippoliti AF. The histology of the stomach in symptomatic patients after gastric surgery: a model to assess selective patterns of gastric mucosal injury. Scand J Gastroenterol Suppl 1985; 109: 77-89
86. Current European concepts in the management of H pylori infection. The Maastricht Consensus Report. European H pylori Study Group. Gut 1997; 41: 8-13
87. Yamaoka Y, Kwon DH, Graham DY. A M(r) 34,000 proinflammatory outer membrane protein (oipA) of H pylori. Proc Natl Acad Sci U S A 2000; 97: 7533-7538
88. Ando T, Wassenaar TM, Peek RM Jr, Aras RA, Tschumi AI, van Doorn LJ, Kusugami K, Blaser MJ. A H pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains. Cancer Res 2002; 62: 2385-2389