A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains

Cancer Research

Volumn 62, Issue 8, 2002, Pages 2385-2389

  Ando, Takafumi ^a,b   Wassenaar, Trudy M ^c   Peek, Richard M ^d   Aras, Rahul A ^a   Tschumi, Ariane I ^a   van Doorn, Leen Jan ^e   Kusugami, Kazuo ^b   Blaser, Martin J ^a,f  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Molec Microbiol/Genom Consultants   (Germany)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Delft Diagnostic Laboratory   (Netherlands)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; INTERLEUKIN 8; RESTRICTION ENDONUCLEASE; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADULT; AGED; APOPTOSIS; ARTICLE; ASIAN; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CAMPYLOBACTER JEJUNI; COCULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA CLEAVAGE; DNA DETERMINATION; DNA SEQUENCE; EPITHELIUM CELL; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; HELICOBACTER PYLORI; HRGA GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN INDUCTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STOMACH CANCER; STRAIN DIFFERENCE;

ADULT; AGED; BACTERIAL PROTEINS; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA, BACTERIAL; FEMALE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; VIRULENCE;

EID: 0037089553     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Hypothesis: The changing relationships of Helicobacter pylori and humans: Implications for health and disease
2. Role of the vacuolating toxin from Helicobacter pylori in the pathogenesis of duodenal and gastric ulcer
3. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
4. Helicobacter pylori and gastric mucosal cytokines: Evidence that CagA-positive strains are more virulent
5. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
6. +Helicobacter pylori strains
7. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan
8. Prevalence and genetic diversity of cagD, cagE, and vacA in Helicobaeter pylori strains isolated from Japanese patients
9. Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population
10. Identification of type II restriction and modification systems in Helicobacter pylori reveals their substantial diversity among strains
11. The complete genome sequence of the gastric pathogen Helicobacter pylori
12. Analysis of the genetic diversity of Helicobacter pylori: The role of two genomes
13. Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome
14. Comparative genomics of the restriction-modification systems in Helicobacter pylori
15. Specificities of eleven different DNA methyltransferases of Helicobacter pylori strain 26695
16. Recognition of DNA by type II restriction enzymes
17. Biology of DNA restriction
18. Recognition and cleavage of DNA by type-II restriction endonucleases
19. Gene structure and expression of the MboI restriction-modification system
20. Restriction-modification system differences in Helicobacter pylori are a barrier to interstrain plasmid transfer
21. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome
22. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori
23. Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease
24. Preparation of genomic DNA from bacteria
25. Chloramphenicol resistance in Campylobacter coli
26. Interleukin-8 activity correlates with histological severity in Helicobacter pylori-associated antral gastritis
27. Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori
28. Promoters of the CATG-specific methyltransferase gene hpyIM differ between iceA1 and iceA2 Helicobacter pylori strains
29. The Helicobacterpylori genome is modified at CATG by the product of hpyIM
30. The Helicobacterpylori vacA sl, ml genotype and cagA is associated with gastric carcinoma in Germany
31. Geographic distribution of vacA aIlelic types of Helicobacter pylori