Association between apolipoprotein E ε4 allele and apathy in probable Alzheimer's disease

Acta Psychiatrica Scandinavica

Volumn 113, Issue 1, 2006, Pages 59-63

  Monastero, R ^a   Mariani, E ^b   Camarda, C ^a   Ingegni, T ^b   Averna, M R ^c   Senin, U ^b   Camarda, R ^a   Mecocci, P ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

Author keywords

Alzheimer's disease; Apolipoprotein E; Behavioural symptoms; Dementia; Logistic models

Indexed keywords

APOLIPOPROTEIN E4;

AGED; AGGRESSION; AGITATION; ALLELE; ALZHEIMER DISEASE; ANXIETY; APATHY; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DATA ANALYSIS; DELUSION; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; EATING; EUPHORIA; FEMALE; FREQUENCY ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HALLUCINATION; HUMAN; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MOTOR DYSFUNCTION; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; SLEEP; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE;

AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; FEMALE; GENOTYPE; HUMANS; MALE; MOOD DISORDERS; NEUROPSYCHOLOGICAL TESTS; SEVERITY OF ILLNESS INDEX;

EID: 33644755923     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.2005.00597.x     Document Type: Article

References (39)

1. M ega MS C ummings JL F iorello T G ornbein J The spectrum of behavioral changes in Alzheimer's disease Neurology 1996 46 130 135
2. L yketsos CG S teinberg M T schanz JT N orton MC S teffens DC B reitner JC Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging Am J Psychiatry 2000 157 708 714
3. G reen RC C upples LA K urz A et al. Depression as a risk factor for Alzheimer disease: the MIRAGE Study Arch Neurol 2003 60 753 759
4. O stling S S koog I Psychotic symptoms and paranoid ideation in a nondemented population-based sample of the very old Arch Gen Psychiatry 2002 59 53 59
5. S tern Y T ang MX A lbert MS et al. Predicting time to nursing home care and death in individuals with Alzheimer disease JAMA 1997 277 806 812
6. N orton LE M alloy PF S alloway S The impact of behavioural symptoms on activities of daily living in patients with dementia Am J Geriatr Psychiatry 2001 9 41 48
7. S teele C R ovner B C hase GA F olstein M Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease Am J Psychiatry 1990 147 1049 1051
8. G onzalez -S alvador T L yketsos CG B aker A et al. Quality of life in dementia patients in long-term care Int J Geriatr Psychiatry 2000 15 181 189
9. S chulz R M endelsohn AB H aley WE et al. Resources for Enhancing Alzheimer's Caregiver Health Investigators. End-of-life care and the effects of bereavement on family caregivers of persons with dementia N Engl J Med 2003 349 1936 1942
10. R aber J H uang Y A shford JW ApoE genotype accounts for the vast majority of AD risk and AD pathology Neurobiol Aging 2004 25 641 650
11. F arrer LA C upples LA H aines JL et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium JAMA 1997 278 1349 1356
12. S cheltens P F ox N B arkhof F D e C arli C Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion Lancet Neurol 2002 1 13 21
13. M uller -T homsen T A rlt S G anzer S et al. Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men Dement Geriatr Cogn Disord 2002 14 59 63
14. R amachandran G M arder K T ang M et al. A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease Neurology 1996 47 256 259
15. S carmeas N B randt J A lbert M et al. Association between the APOE genotype and psychopathologic symptoms in Alzheimer's disease Neurology 2002 58 1182 1188
16. C antillon M H arwood D B arker W et al. No association between apolipoprotein E genotype and late-onset depression in Alzheimer's disease Biol Psychiatry 1997 41 246 248
17. G abryelewicz T R eliga D S tyczynska M et al. Behavioural pathology in Alzheimer's disease with special reference to apolipoprotein E genotype Dement Geriatr Cogn Disord 2002 14 208 212
18. H arwood DG B arker WW O wnby RL St George-Hyslop P, Duara R. Apolipoprotein E genotype and symptoms of psychosis in Alzheimer's disease Am J Geriatr Psychiatry 1999 7 119 123
19. L evy ML C ummings JL F airbanks LA S ultzer DL S mall GW Apolipoprotein E genotype and noncognitive symptoms in Alzheimer's disease Biol Psychiatry 1999 45 422 425
20. L opez OL K amboh MI B ecker JT K aufer DI D e K osky ST The apolipoprotein E epsilon 4 allele is not associated with psychiatric symptoms or extrapyramidal signs in probable Alzheimer's disease Neurology 1997 49 794 797
21. W einer MF V ega G R isser RC et al. Apolipoprotein E epsilon 4, other risk factors, and course of Alzheimer's disease Biol Psychiatry 1999 45 633 638
22. American Psychiatric Association Diagnostic and statistical manual of mental disorders 4th edn Washington American Psychiatric Association 1994
23. M c K hann G D rachman D F olstein M K atzman R P rice D S tadlan EM Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 1984 34 939 944
24. F olstein MF F olstein SE M c H ugh PR Mini mental state: a practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 1975 12 189 198
25. H ixson JE V ernier DT Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI J Lipid Res 1990 31 545 548
26. P anza F S olfrizzi V T orres F et al. Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians Neurosci Lett 1999 277 53 56
27. C ummings JL M ega M G ray K R osenberg -T hompson S C arusi DA G ornbein J The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia Neurology 1994 44 2308 2314
28. B inetti G M ega MS M agni E et al. Behavioral disorders in Alzheimer disease: a transcultural perspective Arch Neurol 1998 55 539 544
29. F risoni GB R ozzini L G ozzetti A et al. Behavioral syndromes in Alzheimer's disease: description and correlates Dement Geriatr Cogn Disord 1999 10 130 138
30. L yketsos CG S heppard JM S teinberg M et al. Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study Int J Geriatr Psychiatry 2001 16 1043 1053
31. A alten P de V ugt ME L ousberg R et al. Behavioral problems in dementia: a factor analysis of the neuropsychiatric inventory Dement Geriatr Cogn Disord 2003 15 99 105
32. C raig AH C ummings JL F airbanks L et al. Cerebral blood flow correlates of apathy in Alzheimer disease Arch Neurol 1996 53 1116 1120
33. M igneco O B enoit M K oulibaly PM et al. Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients Neuroimage 2001 13 896 902
34. T ekin S M ega MS M asterman DM et al. Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease Ann Neurol 2001 49 355 361
35. M c P herson S F airbanks L T iken S C ummings JL B ack -M adruga C Apathy and executive function in Alzheimer's disease J Int Neuropsychol Soc 2002 8 373 381
36. B oyle PA M alloy PF Treating apathy in Alzheimer's disease Dement Geriatr Cogn Disord 2004 17 91 99
37. S oininen H K osunen O H elisalmi S et al. A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele Neurosci Lett 1995 187 79 82
38. Y amaguchi H S ugihara S O gawa A O shima N I hara Y Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects J Neuropathol Exp Neurol 2001 60 731 739
39. L evy ML C ummings JL F airbanks LA B ravi D C alvani M C arta A Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease Am J Psychiatry 1996 153 1438 1443