Antigenotoxicity of Agaricus blazei mushroom organic and aqueous extracts in chromosomal aberration and cytokinesis block micronucleus assays in CHO-k1 and HTC cells

Toxicology in Vitro

Volumn 20, Issue 3, 2006, Pages 355-360

  Bellini, M F ^a   Angeli, J P F ^a   Matuo, R ^a   Terezan, A P ^b   Ribeiro, L R ^c   Mantovani, M S ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Agaricus blazei; Antigenotoxicity; CHO k1 cells; Chromosomal aberration assay; Drug metabolism; HTC cells

Indexed keywords

AGARICUS BLAZEI EXTRACT; BUTANOL; CLASTOGEN; HEXANE; METHANOL;

AGARICUS BLAZEI; AQUEOUS SOLUTION; ARTICLE; CELL LINE; CELL PROTECTION; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; DRUG METABOLISM; FEMALE; GENETIC DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; MEDICINAL PLANT; MICRONUCLEUS TEST; MUSHROOM;

AGARICUS; ANIMALS; ANTIMUTAGENIC AGENTS; CELL LINE; CHO CELLS; CHROMOSOME ABERRATIONS; CRICETINAE; CYTOKINESIS; DNA DAMAGE; MICRONUCLEUS TESTS; RATS;

AGARICUS BLAZEI; BASIDIOMYCOTA;

EID: 33644753739     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.08.009     Document Type: Article

References (20)

1. M.F. Bellini, N.L. Giacomini, A.F. Eira, L.R. Ribeiro, and M.S. Mantovani Anticlastogenic effect of aqueous extracts of Agaricus blazei on CHO-k1 cells, studying different developmental phases of the mushroom Toxicology in Vitro 17 2003 465 469
2. G.C. Bez, B.Q. Jordão, V.E.P. Vicentini, and M.S. Mantovani Differential protection of A and B chlorophyll in MMC-mediated induction of chromatid and isochromatid breaks in human lymphocyte culture Cytologia 66 2001 313 318
3. R. Chang Functional properties of edible mushrooms Nutrition Reviews 54 11 1996 S91 S93
4. R.D. Delmanto, P.L.A. De Lima, M.M. Suguia, D.M.F. Salvadori, A.F. Da Eira, G. Speit, and L.R. Ribeiro Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide Mutation Research 496 2001 15 21
5. M. Fenech The in vitro micronucleus technique Mutation Research 455 2000 81 95
6. M.L. Garriot, J.B. Phelps, and W.P. Hoffman A protocol for the in vitro micronucleus test I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity Mutation Research 517 2002 123 134
7. Z.R. Guterrez, M.S. Mantovani, A.F. Eira, L.R. Ribeiro, and B.Q. Jordão Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro Toxicology in Vitro 18 2004 301 309
8. H. Itoh, H. Amano, and H. Noda Inhibitory action of a (1-6)-β-glucan-protein complex (FIII-2b) isolated from Agaricus blazei Murrill ("Himematsutake") on Meth A fibrosarcoma bearing mice and its antitumor mechanism Japan Journal of Pharmacology 66 1994 265 271
9. H. Kawagishi, R.I. Ryuichi, T. Kanao, T.M. Keishiro, S. Hitoshi, I.T. Hagiwara, and T.O. Nakamura Fractionation and antitumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies Carbohydrate Research 186 1989 267 273
10. P.H.M. Lohman, J.M. Gentile, G. Gentile, and L.R. Ferguson Antimutagenesis/anticarcinogenesis 2001: screening, methods and biomarkers Mutation Research 496 2001 1 4
11. R.C. Luiz, B.Q. Jordão, A.F. Eira, L.R. Ribeiro, and M.S. Mantovani Mechanism of anticlastogenicity of Agaricus blazei Murrill mushroom organic extracts in wild type CHO(k1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays Mutation Research 528 2003 75 79
12. R.C. Luiz, B.Q. Jordão, A.F. Eira, L.R. Ribeiro, and M.S. Mantovani Non-mutagenic or genotoxic effects of medicinal aqueous extracts from the Agaricus blazei mushroom in V79 cells Cytologia 68 2003 1 6
13. K. Manhoharan, and M.R. Banerjee β-carotene reduces sister chromatid exchange induced by chemical carcinogens in mouse mammary cells in organ culture Cell Biology International Report 9 1985 783 789
14. R.C.N. Menoli, M.S. Mantovani, L.R. Ribeiro, S. Gunter, and B.Q. Jordão Antimutagenic effects of the mushroom Agaricus blazei Murill extracts on V79 cells Mutation Research 496 2001 5 13
15. T. Mizuno Bioactive biomolecules of mushrooms-food, function and medicinal effect of mushroom fungi Food Research International 11 1995 7 21
16. J.M. Oliveira, B.Q. Jordão, L.R. Ribeiro, A.F. Eira, and M.S. Mantovani Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro Food and Chemical Toxicology 40 2002 15 20
17. J.B. Phelps, M.L. Garriot, and W. Hoffman A protocol for the in vitro micronucleus test II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity Mutation Research 521 2002 103 112
18. Y. Takeda, H. Togashi, H. Shinzawa, S. Miyano, R. Ishii, T. Karasawa, Y. Takeda, T. Saito, K. Saito, H. Haga, T. Matsuo, M. Aoki, H. Mitsuhashi, H. Watanabe, and T. Takahashi Spontaneous regression of hepatocellular carcinoma and review of literature Journal of Gastroenterology and Hepatology 15 2000 1079 1086
19. S.P. Wasser, and A.L. Weiss Therapeutic effects of substances occurring in higher basidiomycetes mushroom: modern perspective Critical Reviews in Immunology 19 1999 65 96
20. M.D. Waters, A.L. Brady, H.F. Stack, and H.E. Brockman Antimutagenicity profiles for some model compounds Mutation Research 238 1990 57 85