Non-mutagenic or genotoxic effects of medicinal aqueous extracts from the Agaricus blazei mushroom in V79 cells

Cytologia

Volumn 68, Issue 1, 2003, Pages 1-6

  Luiz, R C ^a   Jordao B Q ^a   Da Eira, A F ^b   Ribeiro, L R ^c   Mantovani, M S ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c NONE

Author keywords

Agaricus blazei Murill; Antimutagenesis; Comet assay; Cytokinesis block micronucleus assay; Methyl methanesulphonate; V79 cells

Indexed keywords

AGARICUS; AGARICUS BLAZEI; BASIDIOMYCOTA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0037363659     PISSN: 00114545     EISSN: None     Source Type: Journal    
DOI: 10.1508/cytologia.68.1     Document Type: Article

References (19)

1. Chang, R. 1996. Functional properties of edible mushrooms. Nutrition Rev. 54: 91-93.
2. De Flora, S. 1998. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutat. Res. 402: 151-158.
3. Delmanto, R. D., de Lima, P. L. A., Suguia, M. M., Salvadori, D. M. F., da Eira, A. F., Speit, G. and Ribeiro, L. R. 2001. Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Mutat. Res. 20: 15-21.
4. Fujimiya, Y., Suzuki, Y., Katakura, R. and Ebina, T. 1999. Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from basidiomycete, Agaricus blazei Murill. Anticancer Res. 19: 113-118.
5. _, Oshima, K., Kobori, H., Moriguchi, K., Nakashima, H., Matumoto, Y., Takahara, S., Ebina, T. and Katakura, R. 1998. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol. Immunother. 46: 147-159.
6. Gomes, E. M., Soutot, P. R. F. and Felzenszwalb, I. 1996. Shark-cartilage containing preparation protects cells against hydrogen peroxide induced damage and mutagenesis. Mutat. Res. 367: 203-208.
7. Grüter, A., Friederich, U. and Würgler, F. E. 1990. Antimutagenic effects of mushrooms. Mutat. Res. 231: 243-249.
8. Itoh, H., Ito, H., Amano, H. and Noda, H. 1994. Inhibitory-action of a (1-6)-beta-D-glucan-protein complex (F-III-2-b) isolated from Agaricus blazei Murill (himematsutake) on meth-A fibrosarcoma-bearing mice and its antitumor mechanism. Jap. J. Pharmacol. 66: 265-271.
9. Kada, T. and Shimoi, K. 1987. Desmutagens and bio-antimutagens - Their modes of action. BioAssays 7: 113-115.
10. Kobayashi, H., Sugiyama, C., Morikawa, Y., Hayashi, M. and Sofuni, T. 1995. A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis. MMS Commun. 3: 103-115.
11. Lohman, P. H. M., Gentile, J. M., Gentile, G. and Ferguson, L. R. 2001. Antimutagenesis/anticarcinogenesis 2001: screening, methods and biomarkers. Mutat. Res. 496: 1-4.
12. Menoli, R. C. R. N., Mantovani, M. S., Ribeiro, L. R., Speit, G. and Jordão, B. Q. 2001. Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells. Mutat. Res. 496: 5-13.
13. Oliveira, J. M., Jordão, B. Q., Ribeiro, L. R., Eira, A. F. and Mantovani, M. S. 2002. Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro. Food Chem. Toxicol. (in press)
14. Osaki, Y., Kato, T., Yamamoto, K., Okubo, J. and Miyazaki, T. 1994. Antimutagenic and bactericidal substances in the fruit body of a Basidiomycetes Agaricus blazei. Yakugaku-Zasshi 114: 342-350.
15. Pereira, A. A. B. 1991. Testes Estatisticos para Comparar Proporções em Problemas de Citogenética. In: Rabello-Gay, M. N., Rodrigues, M. A. L. R. and Monteleone-Neto, R. (eds.). Mutagênese, Caminogênese e Teratogênese: Métodos e Critérios de Avaliação, Rev. Brasil. de Genética, Ribeircão Preto, SP, Brasil, pp. 113-121.
16. Schmid, W. 1976. The Micronucleus Test for Cytogenetic Analysis. In: Hollaender, A. (ed.). Chemical Mutagens Vol. 4, Plenum Press, New York, USA, pp. 31-53.
17. Speit, G. and Hartmann, A. 1999. The Comet Assay (Single-Cell Gel Test), A Sensitive Genotoxicity Test for the Detection of DNA Damage and Repair. In: Henderson, D. S. (ed.). Methods in Molecular Biology: DNA Repair Protocols - Eukaryotic Systems. Vol. 113, Totowa: Humana Press, pp. 203-211.
18. Surh, Y. J., Shlyankevich, M., Lee, J. W. and Yoo, J. K. 1996. Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl) carbamoyl] acetate (YH439), a novel hepatoprotective agent. Mutat. Res. 367: 219-224.
19. Titenko-Holland, N., Windham, G., Kolachana, P., Reinisch, F., Parvatham, S., Osorio, A. M. and Smith, M. T. 1997. Genotoxicity of malathion on human lymphocytes assessed using the micronucleus assay in vitro and in vivo: a study of malathion-exposed workers. Mutat. Res. 338: 85-95.