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Jialal I, Devaraj S, Venugopal SK. C-reactive protein: Risk marker or mediator in atherothrombosis? Hypertension 2004; 44:1-6. An excellent review on CRP, indicating that CRP is a risk marker for cardiovascular disease and also a mediator for atherothrombosis.
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Hypertension
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Venugopal SK, Devaraj S, Jialal I. C-reactive protein decreases prostacyclin release from human aortic endothelial cells. Circulation 2003; 108:1676-1678. This is the first study demonstrated that CRP decreases prostacyclin release from HAECs by inactivating PGIS via nitration caused by increased superoxide anion and inducible nitric oxide synthase expression thus providing mechanistic insight for the first time.
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Circulation
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Devaraj S, Kumaresan PR, Jialal I. Effect of C-reactive protein on chemokine expression in human aortic endothelial cells. J Mol Cell Cardiol 2004; 36:405-410. This is the first report to show that interleukin-8 expression at RNA and protein levels was increased by CRP via nuclear factor-κB activation in both HAECs and HCAECs.
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Arterioscler Thromb Vasc Biol
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Circulation
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Biochem Biophys Res Commun
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