-
1
-
-
0033569516
-
Pharmacogenomics: Translating functional genomics into rational therapeutics
-
Evans WE, Belling MV: Pharmacogenomics: Translating functional genomics into rational therapeutics. Science 286:487-491, 1999
-
(1999)
Science
, vol.286
, pp. 487-491
-
-
Evans, W.E.1
Belling, M.V.2
-
2
-
-
0035850303
-
Recommendation for caution with irinotecan, fluorouracil, and leucovorin for colorectal cancer
-
Sargent DJ, Niedzwiecki D, O'Connell MJ, et al: Recommendation for caution with irinotecan, fluorouracil, and leucovorin for colorectal cancer. N Engl J Med 345:144-146, 2001
-
(2001)
N Engl J Med
, vol.345
, pp. 144-146
-
-
Sargent, D.J.1
Niedzwiecki, D.2
O'Connell, M.J.3
-
3
-
-
0035884212
-
Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: Summary findings of an independent panel
-
Rothenberg ML, Meropol NJ, Poplin EA, et al: Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: Summary findings of an independent panel. J Clin Oncol 19:3801-3807, 2001
-
(2001)
J Clin Oncol
, vol.19
, pp. 3801-3807
-
-
Rothenberg, M.L.1
Meropol, N.J.2
Poplin, E.A.3
-
4
-
-
0014433956
-
Genetic control of drug levels in man: Phenylbutazone
-
Vesell ES, Page JG: Genetic control of drug levels in man: Phenylbutazone. Science 159:1479-1480, 1968
-
(1968)
Science
, vol.159
, pp. 1479-1480
-
-
Vesell, E.S.1
Page, J.G.2
-
5
-
-
0014403645
-
Genetic control of drug levels in man: Antipyrine
-
Vesell ES, Page JG: Genetic control of drug levels in man: Antipyrine. Science 161: 72-73, 1968
-
(1968)
Science
, vol.161
, pp. 72-73
-
-
Vesell, E.S.1
Page, J.G.2
-
6
-
-
0014383735
-
Genetic control of dicumarol levels in man
-
Vesell ES, Page JG: Genetic control of dicumarol levels in man. J Clin Invest 47:2657-2663, 1968
-
(1968)
J Clin Invest
, vol.47
, pp. 2657-2663
-
-
Vesell, E.S.1
Page, J.G.2
-
7
-
-
0003775773
-
Pharmacogenetics: Heredity and the Response to Drugs
-
United Kingdom, W.B. Saunders Co
-
Kalow W: Pharmacogenetics: Heredity and the Response to Drugs. Philadelphia, PA and London, United Kingdom, W.B. Saunders Co, 1962
-
(1962)
Philadelphia, PA and London
-
-
Kalow, W.1
-
8
-
-
0037421590
-
Pharmacogenomics: Drug disposition, drug targets, and side effects
-
Evans WE, McLeod HL: Pharmacogenomics: Drug disposition, drug targets, and side effects. N Engl J Med 348:538-549, 2003
-
(2003)
N Engl J Med
, vol.348
, pp. 538-549
-
-
Evans, W.E.1
McLeod, H.L.2
-
9
-
-
0037451804
-
Cancer pharmacogenomics: Current and future applications
-
Watters JW, McLeod HL: Cancer pharmacogenomics: Current and future applications. Biochim Biophys Acta 1603:99-111, 2003
-
(2003)
Biochim Biophys Acta
, vol.1603
, pp. 99-111
-
-
Watters, J.W.1
McLeod, H.L.2
-
12
-
-
0018822866
-
Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
-
Weinshilboum RM, Sladek SL: Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 32:651-662, 1980
-
(1980)
Am J Hum Genet
, vol.32
, pp. 651-662
-
-
Weinshilboum, R.M.1
Sladek, S.L.2
-
13
-
-
0026506140
-
Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
-
Bertilsson L, Lou YQ, Du YL, et al: Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clin Pharmacol Ther 51:388-397, 1992
-
(1992)
Clin Pharmacol Ther
, vol.51
, pp. 388-397
-
-
Bertilsson, L.1
Lou, Y.Q.2
Du, Y.L.3
-
14
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139, 2004
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
15
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500, 2004
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
16
-
-
0035868667
-
Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
-
Villafranca E, Okruzhnov Y, Dominguez MA, et al: Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 19: 1779-1786, 2001
-
(2001)
J Clin Oncol
, vol.19
, pp. 1779-1786
-
-
Villafranca, E.1
Okruzhnov, Y.2
Dominguez, M.A.3
-
17
-
-
16544395591
-
DNA methylation and cancer
-
Das PM, Singal R: DNA methylation and cancer. J Clin Oncol 22:4632-4642, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 4632-4642
-
-
Das, P.M.1
Singal, R.2
-
18
-
-
20644464974
-
Mapping molecular networks using proteomics: A vision for patient-tailored combination therapy
-
Petricoin EF III, Bichsel VE, Calvert VS, et al: Mapping molecular networks using proteomics: A vision for patient-tailored combination therapy. J Clin Oncol 23:3614-3621, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 3614-3621
-
-
Petricoin III, E.F.1
Bichsel, V.E.2
Calvert, V.S.3
-
19
-
-
7944238044
-
Somatic alterations in the human cancer genome
-
Weir B, Zhao X, Meyerson M: Somatic alterations in the human cancer genome. Cancer Cell 6:433-438, 2004
-
(2004)
Cancer Cell
, vol.6
, pp. 433-438
-
-
Weir, B.1
Zhao, X.2
Meyerson, M.3
-
20
-
-
15544384884
-
Gene expression profiling of breast cancer: A new tumor marker
-
van't Veer LJ, Paik S, Hayes DF: Gene expression profiling of breast cancer: A new tumor marker. J Clin Oncol 23:1631-1635, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 1631-1635
-
-
van't Veer, L.J.1
Paik, S.2
Hayes, D.F.3
-
21
-
-
0028022585
-
Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
-
Gupta E, Lestingi TM, Mick R, et al: Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea. Cancer Res 54:3723-3725, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 3723-3725
-
-
Gupta, E.1
Lestingi, T.M.2
Mick, R.3
-
22
-
-
0032519431
-
Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
-
Iyer L, King CD, Whitington PF, et al: Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest 101:847-854, 1998
-
(1998)
J Clin Invest
, vol.101
, pp. 847-854
-
-
Iyer, L.1
King, C.D.2
Whitington, P.F.3
-
23
-
-
0032934383
-
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
-
Iyer L, Hall D, Das S, et al: Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism. Clin Pharmacol Ther 65:576-582, 1999
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 576-582
-
-
Iyer, L.1
Hall, D.2
Das, S.3
-
24
-
-
0033661491
-
Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: Relationship between UGT1A1 promoter genotype and variability in a liver bank
-
Fisher MB, Vandenbranden M, Findlay K, et al: Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: Relationship between UGT1A1 promoter genotype and variability in a liver bank. Pharmacogenetics 10:727-739, 2000
-
(2000)
Pharmacogenetics
, vol.10
, pp. 727-739
-
-
Fisher, M.B.1
Vandenbranden, M.2
Findlay, K.3
-
25
-
-
0036025450
-
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
-
Iyer L, Das S, Janisch L, et al: UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2:43-47, 2002
-
(2002)
Pharmacogenomics J
, vol.2
, pp. 43-47
-
-
Iyer, L.1
Das, S.2
Janisch, L.3
-
26
-
-
0034671387
-
Polymorphisms of UDP- glucuronosyltransferase gene and irinotecan toxicity: A pharmacogenetic analysis
-
Ando Y, Saka H, Ando M, et al: Polymorphisms of UDP- glucuronosyltransferase gene and irinotecan toxicity: A pharmacogenetic analysis. Cancer Res 60:6921-6926, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 6921-6926
-
-
Ando, Y.1
Saka, H.2
Ando, M.3
-
27
-
-
2342459714
-
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
-
Innocenti F, Undevia SD, lyer L, et al: Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22:1382-1388, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 1382-1388
-
-
Innocenti, F.1
Undevia, S.D.2
lyer, L.3
-
28
-
-
17844390172
-
Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions
-
Pao W, Miller VA: Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions. J Clin Oncol 23:2556-2568, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2556-2568
-
-
Pao, W.1
Miller, V.A.2
-
29
-
-
19844375720
-
Epidermal growth factor receptor mutations in non-small-cell lung cancer: Implications for treatment and tumor biology
-
Janne PA, Engelman JA, Johnson BE: Epidermal growth factor receptor mutations in non-small-cell lung cancer: Implications for treatment and tumor biology. J Clin Oncol 23:3227-3234, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 3227-3234
-
-
Janne, P.A.1
Engelman, J.A.2
Johnson, B.E.3
-
30
-
-
0025280026
-
Centre d'etude du polymorphisme humain (CEPH): Collaborative genetic mapping of the human genome
-
Dausset J, Cann H, Cohen D, et al: Centre d'etude du polymorphisme humain (CEPH): Collaborative genetic mapping of the human genome. Genomics 6:575-577, 1990
-
(1990)
Genomics
, vol.6
, pp. 575-577
-
-
Dausset, J.1
Cann, H.2
Cohen, D.3
-
31
-
-
0036842012
-
Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees
-
Schork NJ, Gardner JP, Zhang L, et al: Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees. Hyperten-sion 40:619-628, 2002
-
(2002)
Hyperten-sion
, vol.40
, pp. 619-628
-
-
Schork, N.J.1
Gardner, J.P.2
Zhang, L.3
-
32
-
-
0037370311
-
Natural variation in human gene expression assessed in lymphoblastoid cells
-
Cheung VG, Conlin LK, Weber TM, et al: Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet 33:422-425, 2003
-
(2003)
Nat Genet
, vol.33
, pp. 422-425
-
-
Cheung, V.G.1
Conlin, L.K.2
Weber, T.M.3
-
33
-
-
0141853958
-
Transcriptional response of lymphoblastoid cells to ionizing radiation
-
Jen KY, Cheung VG: Transcriptional response of lymphoblastoid cells to ionizing radiation. Genome Res 13:2092-2100, 2003
-
(2003)
Genome Res
, vol.13
, pp. 2092-2100
-
-
Jen, K.Y.1
Cheung, V.G.2
-
34
-
-
3042616025
-
Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity
-
Dolan ME, Newbold KG, Nagasubramanian R, et al: Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res 64:4353-4356, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 4353-4356
-
-
Dolan, M.E.1
Newbold, K.G.2
Nagasubramanian, R.3
-
35
-
-
4143078229
-
Genome-wide discovery of loci influencing chemotherapy cytotoxicity
-
Watters JW, Kraja A, Meucci MA, et al: Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Proc Natl Acad Sci USA 101:11809-11814, 2004
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 11809-11814
-
-
Watters, J.W.1
Kraja, A.2
Meucci, M.A.3
-
36
-
-
0035295803
-
Susceptibility genes in asthma and allergy
-
Ober C: Susceptibility genes in asthma and allergy. Curr Allergy Asthma Rep 1:174-179, 2001
-
(2001)
Curr Allergy Asthma Rep
, vol.1
, pp. 174-179
-
-
Ober, C.1
-
37
-
-
0035409326
-
Activation of caspase-3 in renal cell carcinoma cells by anthracyclines or 5-fluorouracil
-
Wu XX, Kakehi Y, Mizutani Y, et al: Activation of caspase-3 in renal cell carcinoma cells by anthracyclines or 5-fluorouracil. Int J Oncol 19:19-24, 2001
-
(2001)
Int J Oncol
, vol.19
, pp. 19-24
-
-
Wu, X.X.1
Kakehi, Y.2
Mizutani, Y.3
-
38
-
-
0037085048
-
Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel
-
Kolfschoten GM, Hulscher TM, Duyndam MC, et al: Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel. Biochem Pharmacol 63:733-743, 2002
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 733-743
-
-
Kolfschoten, G.M.1
Hulscher, T.M.2
Duyndam, M.C.3
-
39
-
-
0032950293
-
Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer: International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators
-
Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer: International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators. J Clin Oncol 17: 1356-63, 1999
-
(1999)
J Clin Oncol
, vol.17
, pp. 1356-1363
-
-
-
40
-
-
0032949446
-
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
-
Mamounas E, Wieand S, Wolmark N, et al: Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J Clin Oncol 17:1349-1355, 1999
-
(1999)
J Clin Oncol
, vol.17
, pp. 1349-1355
-
-
Mamounas, E.1
Wieand, S.2
Wolmark, N.3
-
41
-
-
2442684455
-
Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer
-
Wang Y, Jatkoe T, Zhang Y, et al: Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol 22:1564-1571, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 1564-1571
-
-
Wang, Y.1
Jatkoe, T.2
Zhang, Y.3
-
43
-
-
18544365698
-
Gene-expression profiles predict survival of patients with lung adenocarcinoma
-
Beer DG, Kardia SL, Huang CC, et al: Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 8:816-824, 2002
-
(2002)
Nat Med
, vol.8
, pp. 816-824
-
-
Beer, D.G.1
Kardia, S.L.2
Huang, C.C.3
-
44
-
-
0037142053
-
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
-
Rosenwald A, Wright G, Chan WC, et al: The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 346:1937-1947, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 1937-1947
-
-
Rosenwald, A.1
Wright, G.2
Chan, W.C.3
-
45
-
-
20244377046
-
Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia
-
Lugthart S, Cheok MH, den Boer ML, et al: Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell 7:375-386, 2005
-
(2005)
Cancer Cell
, vol.7
, pp. 375-386
-
-
Lugthart, S.1
Cheok, M.H.2
den Boer, M.L.3
-
46
-
-
3543054544
-
Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment
-
Holleman A, Cheok MH, den Boer ML, et al: Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med 351:533-542, 2004
-
(2004)
N Engl J Med
, vol.351
, pp. 533-542
-
-
Holleman, A.1
Cheok, M.H.2
den Boer, M.L.3
-
47
-
-
19944422061
-
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
-
Paik S, Shak S, Tang G, et al: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351:2817-2826, 2004
-
(2004)
N Engl J Med
, vol.351
, pp. 2817-2826
-
-
Paik, S.1
Shak, S.2
Tang, G.3
-
48
-
-
6044278144
-
Evaluating the efficiency of targeted designs for randomized clinical trials
-
Simon R, Maitournam A: Evaluating the efficiency of targeted designs for randomized clinical trials. Clin Cancer Res 10:6759-6763, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6759-6763
-
-
Simon, R.1
Maitournam, A.2
-
50
-
-
0036667985
-
Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice
-
Haston CK, Wang M, Dejournett RE, et al: Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice. Hum Mol Genet 11:1855-1863, 2002
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1855-1863
-
-
Haston, C.K.1
Wang, M.2
Dejournett, R.E.3
-
52
-
-
0037028155
-
The mosaic structure of variation in the laboratory mouse genome
-
Wade CM, Kulbokas EJ III, Kirby AW, et al: The mosaic structure of variation in the laboratory mouse genome. Nature 420:574-578, 2002
-
(2002)
Nature
, vol.420
, pp. 574-578
-
-
Wade, C.M.1
Kulbokas III, E.J.2
Kirby, A.W.3
|