Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the rat

Restorative Neurology and Neuroscience

Volumn 24, Issue 1, 2006, Pages 55-63

  Kunz, Tina ^a   Marklund, Niklas ^b   Hillered, Lars ^b   Oliw, Ernst H ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cox 2 inhibitor; Fluid percussion brain injury; Fluoro Jade b; Neuroinflammation; Prostaglandins; TUNEL staining

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; DIMETHYL SULFOXIDE; ROFECOXIB;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CELL DEATH; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING; TIME; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; CELL COUNT; CELL DEATH; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LACTONES; MALE; NEURONS; ORGANIC CHEMICALS; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS, NONPARAMETRIC; SULFONES; TIME FACTORS;

EID: 33644608758     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. T.A. Baillie, R.A. Halpin, B.K. Matuszewski, L.A. Geer, C.M. Chavez-Eng, D. Dean, M. Braun, G. Doss, A. Jones, T. Marks, D. Melillo and K.P. Vyas, Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques, Drug Metab. Dispos. 29 (2001), 1614-1628.
2. F.M. Bareyre, B. Haudenschild and M.E. Schwab, Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord, J. Neurosci. 22 (2002), 7097-7110.
3. M.K. Bauer, K. Lieb, K. Schulze-Osthoff, M. Berger, P.J. Gebicke-Haerter, J. Bauer and B.L. Fiebich, Expression and regulation of cyclooxygenase-2 in rat microglia, Eur. J. Biochem. 243 (1997), 726-731.
4. M. Burnier, The safety of rofecoxib, Expert Opin. Drug Saf. 4 (2005), 491-499.
5. E. Candelario-Jalil, A. González-Falcón, M. Garcia-Cabrera, D. Alvarez, S. Al-Dalain, G. Martinez, O.S. León and J.E. Springer, Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia, J. Neurochem. 86 (2003), 545-555.
6. E. Candelario-Jalil, A. González-Falcón, M. Garcia-Cabrera, O.S. León and B.L. Fiebich, Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat, Brain Res. 1007 (2004), 98-108.
7. I. Cernak, C. O'Connor and R. Vink, Activation of cyclooxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats, Clin. Exp. Pharmacol. Physiol. 28 (2001), 922-925.
8. I. Cernak, C. O'Connor and R. Vink, Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats, Exp. Brain Res. 147 (2002), 193-199.
9. N.V. Chandrasekharan, H. Dai, K.L. Roos, N.K. Evanson, J. Tomsik, T.S. Elton and D.L. Simmons, COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression, Proc. Natl. Acad. Sci. USA 99 (2002), 13926-13931.
10. J. Chen, T. Marsh, J.S. Zhang and S.H. Graham, Expression of cyclo-oxygenase 2 in rat brain following kainate treatment, Neuroreport 6 (1995), 245-248.
11. K. Chu, S.W. Jeong, K.H. Jung, S.Y. Han, S.T. Lee, M. Kim and J.K. Roh, Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death, J. Cereb. Blood Flow Metab. 24 (2004), 926-933.
12. R.S. Clark, P.M. Kochanek, S.C. Watkins, M. Chen, C.E. Dixon, N.A. Seidberg, J. Melick, J.E. Loeffert, P.D. Nathaniel, K.L. Jin and S.H. Graham, Caspase-3 mediated neuronal death after traumatic brain injury in rats, J. Neurochem. 74 (2000), 740-753.
13. A.C. Conti, R. Raghupathi, J.Q. Trojanowski and T.K. McIntosh, Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period, J. Neurosci. 18 (1998), 5663-5672.
14. P.K. Dash, S.A. Mach and A.N. Moore, Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury, J. Neurotrauma 17 (2000), 69-81.
15. O.L. Gobbo and S.M. O'Mara, Post-treatment, but not pretreatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration, Neuroscience 125 (2004), 317-327.
16. O.L. Gobbo and S.M. O'Mara, Combining exercise and cyclooxygenase-2 inhibition does not ameliorate learning deficits after brain insult, despite an increase in BDNF levels, Brain Res. 1046 (2005), 224-229.
17. J.J. Gopez, H. Yue, R. Vasudevan, A.S. Malik, L.N. Fogelsanger, S. Lewis, D. Panikashvili, E. Shohami, S.A. Jansen, R.K. Narayan and K.I. Strauss, Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury, Neurosurgery 56 (2005), 590-604.
18. R.A. Halpin, L.A. Geer, K.E. Zhang, T.M. Marks, D.C. Dean, A.N. Jones, D. Melillo, G. Doss and K.P. Vyas, The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs, Drug Metab. Dispos. 28 (2000), 1244-1254.
19. R. Hicks, H. Soares, D. Smith and T. McIntosh, Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat, Acta Neuropathol. (Berl) 91 (1996), 236-246.
20. C. Iadecola, K. Niwa, S. Nogawa, X. Zhao, M. Nagayama, E. Araki, S. Morham and M.E. Ross, Reduced susceptibility to ischemic brain injury and N-methyl-D- aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice, Proc. Natl. Acad. Sci. USA 98 (2001), 1294-1299.
21. K. Kawaguchi, R.W. Hickey, M.E. Rose, L. Zhu, J. Chen and S.H. Graham, Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus, Brain Res. 1050 (2005), 130-137.
22. K.A. Kelley, L. Ho, D. Winger, J. Freire-Moar, C.B. Borelli, P.S. Aisen and G.M. Pasinetti, Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2, Am. J. Pathol. 155 (1999), 995-1004.
23. T. Kunz and E.H. Oliw, The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate- induced cell death in the rat hippocampus, Eur. J. Neurosci. 13 (2001), 569-575.
24. T. Kunz and E.H. Oliw, Nimesulide aggravates kainic acid-induced seizures in the rat, Pharmacol. Toxicol. 88 (2001), 271-276.
25. T. Kunz, N. Marklund, L. Hillered and E.H. Oliw, Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat, J. Neurotrauma 19 (2002), 1051-1064.
26. T. Kunz, N. Marklund, L. Hillered and E.H. Oliw, Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat, Brain Res. Cogn. Brain Res. 25 (2005), 829-835.
27. A. Lewén, Y. Skoglösa, F. Clausen, N. Marklund, P.H. Chan, D. Lindholm and L. Hillered, Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury, J. Cereb. Blood Flow Metab. 21 (2001), 344-350.
28. J. Lifshitz, H. Friberg, R.W. Neumar, R. Raghupathi, F.A. Welsh, P. Janmey, K.E. Saatman, T. Wieloch, M.S. Grady and T.K. McIntosh, Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus, J. Cereb. Blood Flow Metab. 23 (2003), 219-231.
29. N. Marklund, F. Clausen, T.K. McIntosh and L. Hillered, Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat, J. Neurotrauma 18 (2001), 821-832.
30. N. Marklund, S. Sihver, B. Långström, M. Bergström and L. Hillered, Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats, J. Neurotrauma 19 (2002), 1139-1153.
31. D.A. Matzilevich, J.M. Rall, A.N. Moore, R.J. Grill and P.K. Dash, High-density microarray analysis of hippocampal gene expression following experimental brain injury, J. Neurosci. Res. 67 (2002), 646-663.
32. T.K. McIntosh, R. Vink, L. Noble, I. Yamakami, S. Fernyak, H. Soares and A.L. Faden, Traumatic brain injury in the rat: characterization of a lateral fluid- percussion model, Neuroscience 28 (1989), 233-244.
33. T.K. McIntosh, M. Juhler and T. Wieloch, Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998, J. Neurotrauma 15 (1998), 731-769.
34. R.K. Narayan, M.E. Michel, B. Ansell, A. Baethmann, A. Biegon, M.B. Bracken, M.R. Bullock, S.C. Choi, G.L. Clifton, C.F. Contant, W.M. Coplin, W.D. Dietrich, J. Ghajar, S.M. Grady, R.G. Grossman, E.D. Hall, W. Heetderks, D.A. Hovda, J. Jallo, R.L. Katz, N. Knoller, P.M. Kochanek, A.I. Maas, J. Majde, D.W. Marion, A. Marmarou, L.F. Marshall, T.K. McIntosh, E. Miller, N. Mohberg, J.P. Muizelaar, L.H. Pitts, P. Quinn, G. Riesenfeld, C.S. Robertson, K.I. Strauss, G. Teasdale, N. Temkin, R. Tuma, C. Wade, M.D. Walker, M. Weinrich, J. Whyte, J. Wilberger, A.B. Young and L. Yurkewicz, Clinical trials in head injury, J. Neurotrauma 19 (2002), 503-557.
35. Consensus conference. Rehabilitation of persons with traumatic brain injury. NIH Consensus Development Panel on Rehabilitation of Persons with Traumatic Brain Injury, JAMA 282 (1999), 974-983.
36. S. Nogawa, F. Zhang, M.E. Ross and C. Iadecola, Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage, J. Neurosci. 17 (1997), 2746-2755.
37. D.M. O'Dell, R. Raghupathi, P.B. Crino, J.H. Eberwine and T.K. McIntosh, Traumatic brain injury alters the molecular fingerprint of TUNEL- positive cortical neurons In vivo: A single-cell analysis, J. Neurosci. 20 (2000), 4821-4828.
38. G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, Inc., San Diego, 1996.
39. R. Raghupathi, Cell death mechanisms following traumatic brain injury, Brain Pathol. 14 (2004), 215-222.
40. A. Rink, K.M. Fung, J.Q. Trojanowski, V.M. Lee, E. Neugebauer and T.K. McIntosh, Evidence of apoptotic cell death after experimental traumatic brain injury in the rat, Am. J. Pathol. 147 (1995), 1575-1583.
41. N.C. Royo, S. Shimizu, J.W. Schouten, J.F. Stover and T.K. McIntosh, Pharmacology of traumatic brain injury, Curr. Opin. Pharmacol. 3 (2003), 27-32.
42. M. Sandrini, G. Vitale and L.A. Pini, Effect of rofecoxib on nociception and the serotonin system in the rat brain, Inflamm. Res. 51 (2002), 154-159.
43. T. Sasaki, K. Kitagawa, K. Yamagata, T. Takemiya, S. Tanaka, E. Omura-Matsuoka, S. Sugiura, M. Matsumoto and M. Hori, Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice, J. Cereb. Blood Flow Metab. 24 (2004), 107-113.
44. C. Scali, M.G. Giovannini, C. Prosperi, A. Bellucci, G. Pepeu and F. Casamenti, The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo, Neuroscience 117 (2003), 909-919.
45. L.C. Schmued and K.J. Hopkins, Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration, Brain Res. 874 (2000), 123-130.
46. S.S. Shaftel, J.A. Olschowka, S.D. Hurley, A.H. Moore and M.K. O'Banion, COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells, Brain Res. Mol. Brain Res. 119 (2003), 213-215.
47. W.L. Smith, D.L. DeWitt and R.M. Garavito, Cyclooxygenases: structural, cellular, and molecular biology, Annu. Rev. Biochem. 69 (2000), 145-182.
48. H.D. Soares, R.R. Hicks, D. Smith and T.K. McIntosh, Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury, J. Neurosci. 15 (1995), 8223-8233.
49. K.I. Strauss, M.F. Barbe, R.M. Marshall, R. Raghupathi, S. Mehta and R.K. Narayan, Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat, J. Neurotrauma 17 (2000), 695-711.