The surface adhesion molecule CXCR4 stimulates mesenchymal stem cell migration to stromal cell-derived factor-1 in vitro but does not decrease apoptosis under serum deprivation

Cardiovascular Revascularization Medicine

Volumn 7, Issue 1, 2006, Pages 19-24

  Bhakta, Shyam ^a   Hong, Ping ^a   Koc, Omer ^a,b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Adhesion molecules; Bone marrow; Cell therapy; Stem cells

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CXCR4; GREEN FLUORESCENT PROTEIN; LIPOCORTIN 5; PROPIDIUM IODIDE; STROMAL CELL DERIVED FACTOR 1;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL GROWTH; CELL ISOLATION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MESENCHYMAL STEM CELL; NORMAL HUMAN; PRIORITY JOURNAL;

APOPTOSIS; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; CHEMOKINES, CXC; CHEMOTAXIS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; MESENCHYMAL STEM CELLS; RECEPTORS, CXCR4; RETROVIRIDAE; TRANSDUCTION, GENETIC;

EID: 33644555222     PISSN: 15538389     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carrev.2005.10.008     Document Type: Article

References (16)

1. AA Mangi, N Noiseux, D Kong, H He, M Rezvani, JS Ingwall, and VJ Dzau Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts Nat Med 9 9 2003 1195 1200
2. + cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice Blood 95 2000 3289 3296
3. ON Koc, SL Gerson, BW Cooper, SM Dyhouse, SE Haynesworth, AI Caplan, and HM Lazarus Rapid hematopoietic recovery after co-infusion of autologous culture-expanded human mesenchymal stem cells and peripheral blood progenitor cells in breast cancer patients receiving high dose chemotherapy J Clin Oncol 18 2000 307 316
4. I Vermes, C Haanen, H Steffens-Nakken, and C Reutelingsperger A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V J Immunol Methods 184 1995 39 51
5. SJ Martin, CP Reutelingsperger, AJ McGahon, JA Rader, RC van Schie, and DM LaFace Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl J Exp Med 182 1995 1545 1556
6. G Koopman, CP Reutelingsperger, GA Kuijten, RM Keehnen, ST Pals, and MH van Oers Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis Blood 84 1994 1415 1420
7. CH Homburg, M de Haas, AE von dem Borne, and AJ Verhoeven Human neutrophils lose their surface FcγRIII and acquire Annexin V binding sites during apoptosis in vitro Blood 85 1995 532 540
8. + progenitors increases their proliferation, migration, and NOD/SCID repopulation Blood 103 8 2004 2942 2949
9. + stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction Circulation 2004 3213 3220
10. K Imai, M Kobayashi, J Wang, Y Ohiro, J Hamada, Y Cho, M Imamura, M Masashi, T Kondo, M Hosokawa, and M Asaka Selective transendothelial migration of hematopoietic progenitor cells: a role in homing of progenitor cells Blood 93 1 1999 149 156
11. J Libura, J Drukala, M Majka, O Tomescu, J Navenot, M Kucia, L Marquez, SC Peiper, FG Barr, A Janowska-Wieczorek, and MZ Ratajczak CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion Blood 100 2002 2597 2606
12. JD Abbott, Y Huang, D Liu, R Hickey, DS Krause, and FJ Giordano Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury Circulation 110 2004 3300 3305
13. AT Askari, S Unzek, ZB Popovic, CK Goldman, F Forudi, M Kiedrowski, A Rovner, SG Ellis, JD Thomas, PE DiCorleto, EJ Topol, and MS Penn Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Lancet 362 2003 697 703
14. GV Silva, S Litovsky, JAR Assad, ALS Sousa, BJ Martin, D Vela, SC Coulter, J Lin, J Ober, WK Vaughn, RVC Branco, EM Oliveira, R He, Y Geng, JT Willerson, and EC Perin Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve function in a canine chronic ischemia model Circulation 111 2005 150 156
15. BE Strauer, M Brehm, T Zeus, M Kostering, A Hernandez, RV Sorg, G Kogler, and P Wernet Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans Circulation 106 2002 1913 1918
16. JS Forrester, MJ Price, and RR Makkar Stem cell repair of infarcted myocardium. An overview for clinicians Circulation 108 2003 1139 1145