Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways

International Immunopharmacology

Volumn 6, Issue 4, 2006, Pages 656-665

  Verhoeckx, Kitty C M ^a,b   Korthout, Henrie A A J ^a   Van Meeteren Kreikamp, A P ^a   Ehlert, Karl A ^a   Wang, Mei ^a   Van Der Greef, Jan ^a,b   Rodenburg, Richard J T ^c   Witkamp, Renger F ^a  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

9 tetrahydrocanabinoid; 9 tetrahydrocanabinoid acid; cAMP; Cannabis sativa; Inflammation; PC PLC; TNF alpha

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CANNABIDIOL; CANNABIDIOLIC ACID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; CANNABIS; DELTA 9 TETRAHYDROCANNABINOID ACID; DRONABINOL; IMMUNOMODULATING AGENT; LIPOPOLYSACCHARIDE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZILPATEROL;

ARTICLE; CELL STRAIN U937; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HEATING; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOPHARMACOLOGY; IMMUNOSTIMULATION; LONG TERM EXPOSURE; MACROPHAGE; METABOLISM; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS REGULATION; SUPERNATANT; UPREGULATION;

CANNABIS; CELL LINE; CELLS, CULTURED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; HUMANS; IMMUNOLOGIC FACTORS; MACROPHAGE ACTIVATION; MACROPHAGES; PHOSPHOLIPASE C; PLANT EXTRACTS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SIGNAL TRANSDUCTION; TETRAHYDROCANNABINOL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33644551536     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2005.10.002     Document Type: Article

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