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Volumn 176, Issue 5, 2006, Pages 3019-3027

Potent inhibition of macrophage responses to IFN-γ by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LIPOPROTEIN; MANNAN; PEPTIDOGLYCAN; PHOSPHATIDYLINOSITOL; SIGNAL PEPTIDASE; TOLL LIKE RECEPTOR 2;

EID: 33644516283     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.5.3019     Document Type: Article
Times cited : (101)

References (46)
  • 4
    • 0025110202 scopus 로고
    • Lymphocyte subsets in granulomas of human tuberculosis: An in situ immunofluorescence study using monoclonal antibodies
    • Randhawa, P. S. 1990. Lymphocyte subsets in granulomas of human tuberculosis: an in situ immunofluorescence study using monoclonal antibodies. Pathology 22: 153-155.
    • (1990) Pathology , vol.22 , pp. 153-155
    • Randhawa, P.S.1
  • 5
    • 0036226541 scopus 로고    scopus 로고
    • Distribution of IFN-γ, IL-4 and TNF-α protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas
    • Fenhalls, G., L. Stevens, J. Bezuidenhout, G. E. Amphlett, K. Duncan, P. Bardin, and P. T. Lukey. 2002. Distribution of IFN-γ, IL-4 and TNF-α protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas. Immunology 105: 325-335.
    • (2002) Immunology , vol.105 , pp. 325-335
    • Fenhalls, G.1    Stevens, L.2    Bezuidenhout, J.3    Amphlett, G.E.4    Duncan, K.5    Bardin, P.6    Lukey, P.T.7
  • 7
    • 0026549480 scopus 로고
    • Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages
    • Chan, J., Y. Xing, R. S. Magliozzo, and B. R. Bloom. 1992. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 175: 1111-1122.
    • (1992) J. Exp. Med. , vol.175 , pp. 1111-1122
    • Chan, J.1    Xing, Y.2    Magliozzo, R.S.3    Bloom, B.R.4
  • 8
    • 0021967854 scopus 로고
    • Interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria
    • Douvas, G. S., D. L. Looker, A. E. Vatter, and A. J. Crowle. 1985. γ Interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect. Immun. 50: 1-8.
    • (1985) Infect. Immun. , vol.50 , pp. 1-8
    • Douvas, G.S.1    Looker, D.L.2    Vatter, A.E.3    Crowle, A.J.4
  • 9
    • 0023228483 scopus 로고
    • Mycobacterial growth inhibition by interferon-γ-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis
    • Flesch, I., and S. H. Kaufmann. 1987. Mycobacterial growth inhibition by interferon-γ-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J. Immunol 138: 4408-4413.
    • (1987) J. Immunol. , vol.138 , pp. 4408-4413
    • Flesch, I.1    Kaufmann, S.H.2
  • 10
    • 0025359011 scopus 로고
    • Activation of tuberculostatic macrophage functions by γ-interferon, interleukin-4, and tumor necrosis factor
    • Flesch, I. E., and S. H. Kaufmann. 1990. Activation of tuberculostatic macrophage functions by γ-interferon, interleukin-4, and tumor necrosis factor. Infect. Immun. 58: 2675-2677.
    • (1990) Infect. Immun. , vol.58 , pp. 2675-2677
    • Flesch, I.E.1    Kaufmann, S.H.2
  • 11
    • 0025787894 scopus 로고
    • Interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: Antimicrobial role of limiting intracellular iron
    • Murray, H. W., A. M. Granger, and R. F. Teitelbaum. 1991. γ Interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron. Infect. Immun. 59: 4684-4686.
    • (1991) Infect. Immun. , vol.59 , pp. 4684-4686
    • Murray, H.W.1    Granger, A.M.2    Teitelbaum, R.F.3
  • 12
    • 0020502358 scopus 로고
    • Identification of Interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity
    • Nathan, C. F., H. W. Murray, M. E. Wiebe, and B. Y. Rubin. 1983. Identification of Interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity, J. Exp. Med. 158: 670-689.
    • (1983) J. Exp. Med. , vol.158 , pp. 670-689
    • Nathan, C.F.1    Murray, H.W.2    Wiebe, M.E.3    Rubin, B.Y.4
  • 14
    • 0022493438 scopus 로고
    • Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: Comparison of the effects of recombinant γ-interferon on human monocytes and murine peritoneal macrophages
    • Rook, G. A., J. Steele, M. Ainsworth, and B. R. Champion. 1986. Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant γ-interferon on human monocytes and murine peritoneal macrophages. Immunology 59: 333-338.
    • (1986) Immunology , vol.59 , pp. 333-338
    • Rook, G.A.1    Steele, J.2    Ainsworth, M.3    Champion, B.R.4
  • 15
    • 2442544416 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis inhibits macrophage responses to IFN-γ through myeloid differentiation factor 88-dependent and -independent mechanisms
    • Fortune, S. M., A. Solache, A. Jaeger, P. J. Hill, J. T. Belisle, B. R. Bloom, E. J. Rubin, and J. D. Ernst. 2004. Mycobacterium tuberculosis inhibits macrophage responses to IFN-γ through myeloid differentiation factor 88-dependent and -independent mechanisms. J. Immunol. 172: 6272-6280.
    • (2004) J. Immunol. , vol.172 , pp. 6272-6280
    • Fortune, S.M.1    Solache, A.2    Jaeger, A.3    Hill, P.J.4    Belisle, J.T.5    Bloom, B.R.6    Rubin, E.J.7    Ernst, J.D.8
  • 16
    • 0035887504 scopus 로고    scopus 로고
    • Reprogramming of the macrophage transcriptome in response to interferon-γ and Mycobacterium tuberculosis: Signaling roles of nitric oxide synthase-2 and phagocyte oxidase
    • Ehrt, S., D. Schnappinger, S. Bekiranov, J. Drenkow, S. Shi, T. R. Gingeras, T. Gaasterland, G. Schoolnik, and C. Nathan. 2001. Reprogramming of the macrophage transcriptome in response to interferon-γ and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 194: 1123-1140.
    • (2001) J. Exp. Med. , vol.194 , pp. 1123-1140
    • Ehrt, S.1    Schnappinger, D.2    Bekiranov, S.3    Drenkow, J.4    Shi, S.5    Gingeras, T.R.6    Gaasterland, T.7    Schoolnik, G.8    Nathan, C.9
  • 17
    • 0037037584 scopus 로고    scopus 로고
    • Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide synthase 2-independent defense in mice
    • Jung, Y. J., R. LaCourse, L. Ryan, and R. J. North. 2002. Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide synthase 2-independent defense in mice. J. Exp. Med. 196: 991-998.
    • (2002) J. Exp. Med. , vol.196 , pp. 991-998
    • Jung, Y.J.1    LaCourse, R.2    Ryan, L.3    North, R.J.4
  • 18
    • 0033214553 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis inhibits IFN-γ transcriptional responses without inhibiting activation of STAT1
    • Ting, L. M., A. C. Kim, A. Cattamanchi, and J. D. Ernst. 1999. Mycobacterium tuberculosis inhibits IFN-γ transcriptional responses without inhibiting activation of STAT1. J. Immunol. 163: 3898-3906.
    • (1999) J. Immunol. , vol.163 , pp. 3898-3906
    • Ting, L.M.1    Kim, A.C.2    Cattamanchi, A.3    Ernst, J.D.4
  • 19
    • 0042635767 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-γ without inhibiting STAT1 function
    • Kincaid, E. Z., and J. D. Ernst. 2003. Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-γ without inhibiting STAT1 function. J. Immunol. 171: 2042-2049.
    • (2003) J. Immunol. , vol.171 , pp. 2042-2049
    • Kincaid, E.Z.1    Ernst, J.D.2
  • 20
    • 0034630456 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis inhibits MHC class II antigen processing in murine bone marrow macrophages
    • Noss, E. H., C. V. Harding, and W. H. Boom. 2000. Mycobacterium tuberculosis inhibits MHC class II antigen processing in murine bone marrow macrophages. Cell. Immunol. 201: 63-74.
    • (2000) Cell. Immunol. , vol.201 , pp. 63-74
    • Noss, E.H.1    Harding, C.V.2    Boom, W.H.3
  • 21
    • 0035879108 scopus 로고    scopus 로고
    • Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis
    • Noss, E. H., R. K. Pai, T. J. Sellati, J. D. Radolf, J. Belisle, D. T. Golenbock, W. H. Boom, and C. V. Harding. 2001. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J. Immunol. 167: 910-918.
    • (2001) J. Immunol. , vol.167 , pp. 910-918
    • Noss, E.H.1    Pai, R.K.2    Sellati, T.J.3    Radolf, J.D.4    Belisle, J.5    Golenbock, D.T.6    Boom, W.H.7    Harding, C.V.8
  • 22
    • 1842484130 scopus 로고    scopus 로고
    • Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton mycobacterial lipoprotein
    • Fulton, S. A., S. M. Reba, R. K. Pai, M. Pennini, M. Torres, C. V. Harding, and W. H. Boom. 2004. Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton mycobacterial lipoprotein. infect, Immun. 72: 2101-2110.
    • (2004) Infect. Immun. , vol.72 , pp. 2101-2110
    • Fulton, S.A.1    Reba, S.M.2    Pai, R.K.3    Pennini, M.4    Torres, M.5    Harding, C.V.6    Boom, W.H.7
  • 23
    • 0036774617 scopus 로고    scopus 로고
    • Specialized transduction: An efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis
    • Bardarov, S., S. Bardarov, Jr., M. S. Pavelka, Jr., V. Sambandamurthy, M. Larsen, J. Tufariello, J. Chan, G. Hatfull, and W. R. Jacobs, Jr. 2002. Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148; 3007-3017.
    • (2002) Microbiology , vol.148 , pp. 3007-3017
    • Bardarov, S.1    Bardarov Jr., S.2    Pavelka Jr., M.S.3    Sambandamurthy, V.4    Larsen, M.5    Tufariello, J.6    Chan, J.7    Hatfull, G.8    Jacobs Jr., W.R.9
  • 25
    • 0004230180 scopus 로고    scopus 로고
    • Hatfull, G. F., and W. R. Jacobs, Jr., eds. ASM Press, Washington, DC
    • Hatfull, G. F., and W. R. Jacobs, Jr., eds. 2000. Molecular Genetics of Mycobacteria. ASM Press, Washington, DC.
    • (2000) Molecular Genetics of Mycobacteria
  • 26
    • 0142241439 scopus 로고    scopus 로고
    • Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-γ
    • Nagabhushanam, V., A. Solache, L. M. Ting, C. J. Escaron, J. Y. Zhang, and J. D. Ernst. 2003. Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-γ. J. Immunol. 171: 4750-4757.
    • (2003) J. Immunol. , vol.171 , pp. 4750-4757
    • Nagabhushanam, V.1    Solache, A.2    Ting, L.M.3    Escaron, C.J.4    Zhang, J.Y.5    Ernst, J.D.6
  • 27
    • 4043072746 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis LprG (Rv1411c): A novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing
    • Gehring, A. J., K. M. Dobos, J. T. Belisle, C. V. Harding, and W. H. Boom. 2004. Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing. J. Immunol. 173: 2660-2668.
    • (2004) J. Immunol. , vol.173 , pp. 2660-2668
    • Gehring, A.J.1    Dobos, K.M.2    Belisle, J.T.3    Harding, C.V.4    Boom, W.H.5
  • 29
    • 7944226058 scopus 로고    scopus 로고
    • Lipoproteins of Mycobacterium tuberculosis: An abundant and functionally diverse class of cell envelope components
    • Sutcliffe, I. C., and D. J. Harrington. 2004. Lipoproteins of Mycobacterium tuberculosis: an abundant and functionally diverse class of cell envelope components. FEMS Microbiol. Rev. 28: 645-659.
    • (2004) FEMS Microbiol. Rev. , vol.28 , pp. 645-659
    • Sutcliffe, I.C.1    Harrington, D.J.2
  • 31
    • 0033215123 scopus 로고    scopus 로고
    • Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
    • Means, T. K., S. Wang, E. Lien, A. Yoshimura, D. T. Golenbock, and M. J. Fenton. 1999. Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163: 3920-3927.
    • (1999) J. Immunol. , vol.163 , pp. 3920-3927
    • Means, T.K.1    Wang, S.2    Lien, E.3    Yoshimura, A.4    Golenbock, D.T.5    Fenton, M.J.6
  • 34
    • 0034780463 scopus 로고    scopus 로고
    • Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages
    • Jones, B. W., K. A. Heldwein, T. K. Means, J. J. Saukkonen, and M. J. Fenton. 2001. Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages. Ann. Rheum. Dis. 60(Suppl. 3): iii6-iii12.
    • (2001) Ann. Rheum. Dis. , vol.60 , Issue.SUPPL. 3
    • Jones, B.W.1    Heldwein, K.A.2    Means, T.K.3    Saukkonen, J.J.4    Fenton, M.J.5
  • 35
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi, O., S. Sato, T. Horiuchi, K. Hoshino, K. Takeda, Z. Dong, R. L. Modlin, and S. Akira. 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169: 10-14.
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5    Dong, Z.6    Modlin, R.L.7    Akira, S.8
  • 37
    • 0042766347 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits γ interferon-regulated HLA-DR and FcγR1 on human macrophages through Toll-like receptor 2
    • Gehring, A. J., R. E. Rojas, D. H. Canaday, D. L. Lakey, C. V. Harding, and W. H. Boom. 2003. The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits γ interferon-regulated HLA-DR and FcγR1 on human macrophages through Toll-like receptor 2. Infect. Immun. 71: 4487-4497.
    • (2003) Infect. Immun. , vol.71 , pp. 4487-4497
    • Gehring, A.J.1    Rojas, R.E.2    Canaday, D.H.3    Lakey, D.L.4    Harding, C.V.5    Boom, W.H.6
  • 38
    • 0037530648 scopus 로고    scopus 로고
    • Inhibition of IFN-γ-induced class I1 transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: A potential mechanism for immune evasion
    • Pai, R. K., M. Convery, T. A. Hamilton, W. H. Boom, and C. V. Harding. 2003. Inhibition of IFN-γ-induced class I1 transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion. J. Immunol 171: 175-184.
    • (2003) J. Immunol. , vol.171 , pp. 175-184
    • Pai, R.K.1    Convery, M.2    Hamilton, T.A.3    Boom, W.H.4    Harding, C.V.5
  • 39
    • 0035914978 scopus 로고    scopus 로고
    • Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation
    • Ramachandra, L., E. Noss, W. H. Boom, and C. V. Harding. 2001. Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation. J. Exp. Med. 194: 1421-1432.
    • (2001) J. Exp. Med. , vol.194 , pp. 1421-1432
    • Ramachandra, L.1    Noss, E.2    Boom, W.H.3    Harding, C.V.4
  • 40
    • 1642375617 scopus 로고    scopus 로고
    • Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent- negative regulation of proinflammatory cytokines by mycobacterial lipomannans
    • Quesniaux, V. ]., D. M. Nicolle, D. Torres, L. Kremer, Y. Guerardel, J. Nigou, G. Puzo, F. Erard, and B. Ryffel. 2004. Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J. Immunol. 172: 4425-4434.
    • (2004) J. Immunol. , vol.172 , pp. 4425-4434
    • Quesniaux, V.1    Nicolle, D.M.2    Torres, D.3    Kremer, L.4    Guerardel, Y.5    Nigou, J.6    Puzo, G.7    Erard, F.8    Ryffel, B.9
  • 41
    • 1842588685 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages
    • Dao, D. N., L. Kremer, Y. Guerardel, A. Molano, W. R. Jacobs, Jr., S. A. Porcelli, and V. Briken. 2004. Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages. Infect, Immun. 72: 2067-2074.
    • (2004) Infect. Immun. , vol.72 , pp. 2067-2074
    • Dao, D.N.1    Kremer, L.2    Guerardel, Y.3    Molano, A.4    Jacobs Jr., W.R.5    Porcelli, S.A.6    Briken, V.7
  • 43
    • 0043267978 scopus 로고    scopus 로고
    • Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guerin peptidoglycan
    • Uehori, J., M. Matsumoto, S. Tsuji, T. Akazawa, O. Takeuchi, S. Akira, T. Kawata, I. Azuma, K. Toyoshima, and T. Seya. 2003. Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guerin peptidoglycan. Infect. Immun. 71: 4238-4249.
    • (2003) Infect. Immun. , vol.71 , pp. 4238-4249
    • Uehori, J.1    Matsumoto, M.2    Tsuji, S.3    Akazawa, T.4    Takeuchi, O.5    Akira, S.6    Kawata, T.7    Azuma, I.8    Toyoshima, K.9    Seya, T.10
  • 46
    • 0033662322 scopus 로고    scopus 로고
    • SOCS Proteins regulators of intracellular signaling
    • Chen, X. P., J. A. Losman, and P. Rothman. 2000. SOCS Proteins regulators of intracellular signaling. Immunity 13: 287-290.
    • (2000) Immunity , vol.13 , pp. 287-290
    • Chen, X.P.1    Losman, J.A.2    Rothman, P.3


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