Mechanistic insight into acetylcholinesterase inhibition and acute toxicity of organophosphorus compounds: A molecular modeling study

Chemical Research in Toxicology

Volumn 19, Issue 2, 2006, Pages 209-216

  Guo, Jian Xin ^a   Wu, Jay J Q ^b   Wright, Jeffery B ^c   Lushington, Gerald H ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b VM Discovery   (United States)

^c US Army Research Development and Engineering Command   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; LIGAND; ORGANOPHOSPHORUS COMPOUND;

ABSORPTION; ACUTE TOXICITY; ARTICLE; BIOTRANSFORMATION; CORRELATION ANALYSIS; ENTHALPY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXCRETION; METABOLISM; MOLECULAR MODEL; PHENOMENOLOGY; QUANTUM MECHANICS; TOXICOKINETICS; VALIDATION PROCESS;

ABSORPTION; ACETYLCHOLINESTERASE; ADMINISTRATION, ORAL; ANIMALS; BIOTRANSFORMATION; CHOLINESTERASE INHIBITORS; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORYLATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 33644510766     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050090r     Document Type: Article

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