An adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 25, 2003, Pages 15101-15106

  Zhang, Lixin ^a,b   Tang, Yucheng ^a   Akbulut, Hakan ^a,c   Zelterman, Daniel ^a,b   Linton, Phyllis Jean ^a   Deisseroth, Albert B ^a  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ANKARA UNIVERSITY   (Turkey)

Author keywords

E7 viral antigen; Immunotherapy; Memory cells; MUC 1 antigen; T cells

Indexed keywords

ADENOVIRUS VECTOR; CANCER VACCINE; CD40 LIGAND; CD8 ANTIGEN; HUMAN PAPILLOMAVIRUS E7 FOREIGN ANTIGEN; HYBRID PROTEIN; MUCIN 1; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CANCER IMMUNOTHERAPY; CELL ACTIVATION; CELLULAR IMMUNITY; CLONAL ANERGY; CONTROLLED STUDY; DENDRITIC CELL; DRUG MECHANISM; GENETIC CODE; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; ANTIGENS; ANTIGENS, NEOPLASM; CA-15-3 ANTIGEN; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DENDRITIC CELLS; FEMALE; GENETIC VECTORS; IMMUNOTHERAPY; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, NUDE; MICE, TRANSGENIC; PAPILLOMAVIRIDAE; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

ADENOVIRIDAE; ANIMALIA; HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRUS;

EID: 0344736643     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2135379100     Document Type: Article

References (19)

1. Xiang, R., Primus, F. J., Ruehlmnn, J. M., Niethammer, A. G., Silletti, S., Lode, H. N., Dolman, C. S., Gillies, S. D. & Reisfeld, R. A. (2001) J. Immunol. 167, 4560-4565.
2. Karpuses, M., Hsu, Y. M., Wang, J. H., Thompson, J., Lederman, S., Chess, L. & Thomas, D. (1995) Structure (London) 3, 1031-1039.
3. Gallichan, W. S. & Rosenthal, K. L. (1996) J. Exp. Med. 184, 1879-1890.
4. Bosch, F. X., Manos, M. M., Munoz, N., Sherman, M., Jansen, A. M., Peto, J., Schiffman, M. H., Moreno, V., Kurman, R. & Shah, K. V. (1995) J. Natl. Cancer Inst. 87, 796-802.
5. Morozov, A., Shiyanov, P., Barr, E., Leiden, J. M. & Raychaudhuri, P. (1997) J. Virol. 71, 3451-3457.
6. Kadish, A. S., Timmons, P., Wang, Y., Ho, G. Y. F., Burk, R. D., Ketz, J., He, W., Romney, S. L., Johnson, A., Angeletti, R., et al. (2002) Cancer Epidemiol. Biomarkers. Prev. 11, 483-488.
7. Goodwin, E. C. & DiMaio, D. (2000) Proc. Natl. Acad. Sci. USA 97, 12513-12517.
8. Hu, G., Liu, W., Mendelsohn, J., Ellis, L., Radinsky, R. & Deisseroth, A. B. (1997) J. Natl. Cancer Inst. 89, 1271-1277.
9. Taylor-Papadimitriou, J., Burchell, J., Miles, D. W. & Dalziel, M. (1999) Biochim. Biophys. Acta 1455, 301-313.
10. Koido, S., Kashiwaba, M., Chen, D. S., Gendler, S., Kufe, D. & Gong, J. L. (2000) J. Immunol. 165, 5713-5719.
11. Tempero, R. M., VanLith, M. L., Morikane, K., Rowse, G. J., Gendler, S. J. & Hollingsworth, M. A. (1998) J. Immunol. 161, 5500-5506.
12. He, Z., Wlazlo, A. P., Kowalczyk, D., Cheng, J., Xiang, Z. Q., Giles-Davis, W. & Ertl, H. C. J. (2000) Virology 270, 146-161.
13. Lin, K. Y., Guamieri, F. G., Staveley-O'Carroll, K. F., Levitsky, H. I., August, J. T., Pardoil, D. M. & Wu, T. C. (1996) Cancer Res. 56, 21-26.
14. Ribas, A., Butterfield, L. H., Amarnani S. N., Dissette, V. B., Kim, D., Meng, W. S., Miranda, G. A., Wang, H. J., McBride, W. H., Glaspy, J. A. & Economou, J. S. (2001) Cancer Res. 61, 8787-8793.
15. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. & Steinman, R. M. (1992) J. Exp. Med. 176, 1693-1702.
16. Li, J., Sun, Y. & Garen, A. (2002) Proc. Natl Acad. Sci. USA 99, 16232-16236.
17. Kikuchi, T., Moore, M. A. & Crystal, R. G. (2000) Blood 96, 91-99.
18. Barratt-Boyes, S. M., Vlad, A. & Finn, O. J. (1999) Clin. Cancer Res. 5, 1918-1924.
19. Tempero, R. M., Rowe, G. J., Gendler, S. J. & Hollingsworth, M. A. (1999) Int. J. Cancer 80, 595-599.