Association of the human adiponectin gene and insulin resistance

European Journal of Human Genetics

Volumn 12, Issue 3, 2004, Pages 199-205

  Filippi, Emanuela ^a   Sentinelli, Federica ^a   Trischitta, Vincenzo ^a,b   Romeo, Stefano ^a   Arca, Marcello ^a   Leonetti, Frida ^a   Di Mario, Umberto ^a   Baroni, Marco Giorgio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CSS Scientific Institute   (Italy)

Author keywords

Adiponectin gene; BMI (body mass index); Insulin resistance; Real time PCR; Single nucleotide polymorphisms (SNPs)

Indexed keywords

ADIPONECTIN; GUANINE; INSULIN; TYROSINE;

ADIPOCYTE; ADULT; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; HETEROZYGOSITY; HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; BASE SEQUENCE; BODY MASS INDEX; FEMALE; GUANINE; HUMANS; INSULIN; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; THYMINE;

EID: 3342997341     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201120     Document Type: Article

References (32)

1. Weyer C, Funahashi T, Tanaka S et al: Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930-1935.
2. Hotta K, Funahashi T, Arita Y et al: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20: 1595-1599.
3. Kumada M, Kihara S, Sumitsuji S et al: Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003; 23: 85-89.
4. Tschritter O, Fritsche A, Thamer C et al: Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003; 52: 239-243.
5. Lindsay RS, Funahashi T, Hanson RL et al: Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 2002; 360: 57-58.
6. Spranger J, Kroke A, Mohlig M et al: Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003; 361: 226-228.
7. Maeda N, Takahashi M, Funahashi T et al: PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50: 2094-2099.
8. Kissebah AH, Sonnenberg GE, Myklebust J et al: Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci USA 2000; 97: 14478-14483.
9. Vionnet N, Hani El-H, Dupont S et al: Genome wide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 2000; 67: 1470-1480.
10. Kondo H, Shimomura I, Matsukawa Y et al: Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002; 51: 2325-2328.
11. Hara K, Boutin P, Mori Y et al: Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002; 51: 536-540.
12. Menzaghi C, Ercolino T, Di Paola R et al: A haplotype in the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002; 51: 2306-2312.
13. Stumvoll M, Tschritter O, Fritsche A et al: Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002; 51: 37-41.
14. Vasseur F, Helbecque N, Dina C et al: Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 2002; 11: 2607-2614.
15. Rose GA, Blackburn H: Cardiovascular Survey Methods, 1st edn., No. 56. Geneva (Switzerland): World Health Organization; 1968.
16. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Diabetes Care 2001; 24 (Suppl 1): S5.
17. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation 1999.
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
19. Wittwer CT, Ririe KM, Andrew RV, David DA, Gundry RA, Balls UJ: The LightCycler: a microvolume multisample fluorimeter with rapid temperature control. Biotechniques 1997; 22: 176-181.
20. Ririe KM, Rasmussen RP, Wittwer CT.:Product differentiation by analysis of DNA melting curves during the polymerase chain reaction. Anal Biochem 1997; 245: 154-160.
21. Bernard PS, Pitham GH, Wittwer CT: Color multiplexing hybridization probes using the aploprotein E locus as a model system for genotyping. Anal Biochem 1999; 273: 221-228.
22. Daly LE, Bourke GJ, McGilvray J: Interpretation and Uses of Medical Statistics, Fifth edition. Oxford: Blackwell Scientific Publications; 2000.
23. Baroni MG, Alcolado JC, Pozzilli P, Cavallo MG, Li SR, Galton DJ: Polymorphisms at the GLUT2 (beta-cell/liver) glucose transporter gene and non-insulin-dependent diabetes mellitus (NIDDM): analysis in affected pedigree members. Clin Genet 1992; 41: 229-234.
24. Hill WG, Robertson A: Linkage disequilibrium of finite populations. Theor Appl Genet 1968; 38: 226-231.
25. Lewontin RC: The interaction of selection and linkage 1. General considerations: heterotic models. Genetics 1984; 49: 49-67.
26. Yang WS, Tsou PL, Lee WJ et al: Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity. J Mol Med 2003, May 16 (Epub ahead of print).
27. Jupe ER, Badgett AA, Neas BR et al: Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. Lancet 2001; 357: 1588-1589.
28. Wong PM, Yuan Q, Chen H, Sultzer BM, Chung SW: A single point mutation at the 3′-UTR of Ran mRNA leads to profound changes in lipopolysaccharide endotoxin-mediated responses. J Biol Chem 2001; 276: 33129-33138.
29. Xia JB, Sherer SW, Cohen PT et al: A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Diabetes 1998; 47: 1519-1524.
30. Frittitta L, Erccolino T, Bozzali M et al: A cluster of 3 single nucleotide polymorphisms in the 3′-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and associates with increased PC-1 protein content and insulin resistance related abnormalities. Diabetes 2001; 50: 1952-1955.
31. Di Paola R, Frittitta L, Miscio G et al: A variation in 3′ UTR of hPTP1B increases specific gene expression and associates with insulin resistance. Am J Hum Genet 2002; 70: 806-812.
32. Yamamoto Y, Hirose H, Saito I et al: Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) 2002; 103: 137-142.