Inhibition of Bone Resorption in Vitro and Prevention of Ovariectomy-Induced Bone Loss in Vivo by Flurbiprofen Nitroxybutylester (HCT1026)

Arthritis and Rheumatism

Volumn 44, Issue 9, 2001, Pages 2185-2192

  Armour, Kenneth J ^a   Van 'T Hof, Robert J ^a   Armour, Katharine E ^a   Torbergsen, Anne C ^a   Del Soldato, Piero ^b   Ralston, Stuart H ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b NicOx SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; FLURBIPROFEN; FLURBIPROFEN 4 NITROXYBUTYL ESTER; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL; ARTICLE; C57BL MOUSE; CELL CULTURE; CELL DIVISION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FEMALE; IN VITRO STUDY; MOUSE; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; SPLEEN;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BONE RESORPTION; CELL DIVISION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLURBIPROFEN; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOCLASTS; OVARIECTOMY; SPLEEN;

EID: 0035462290     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200109)44:9<2185::AID-ART372>3.0.CO;2-3     Document Type: Article

References (30)

1. Lowik CWGM, Nibbering PH, van der Ruit M, Papapoulos SE. Inducible production of nitric oxide in osteoblast like cells and in fetal bone explants is associated with supression of osteoclastic bone resorption. J Clin Invest 1994;93:1465-72.
2. van 't Hof RJ, Armour KJ, Smith LM, Armour KE, Wei XQ, Liew FY, et al. Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption. Proc Natl Acad Sci USA 2000;97:7993-8.
3. Armour KE. van 't Hof RJ, Grabowski PS, Reid DM, Ralston SH. Evidence for a pathogenic role of nitric oxide in inflammation-induced osteoporosis. J Bone Miner Res 1999;14:2137-42.
4. Armour KE, Ralston SH. Estrogen upregulates endothelial constitutive nitric oxide synthase expression in human osteoblast-like cells. Endocrinology 1998;139:799-802.
5. Chow JW, Fox SW, Lean JM, Chambers TJ. Role of nitric oxide and prostaglandins in mechanically induced bone formation. J Bone Miner Res 1998;13:1039-44.
6. Hughes FJ, Buttery LD, Hukkanen MV, O'Donnell A, Maclouf J, Polak JM. Cytokine-induced prostaglandin E2 synthesis and cyclooxygenase-2 activity arc regulated both by a nitric oxide-dependent and -independent mechanism in rat osteoblasts in vitro. J Biol Chem 1999;274:1776-82.
7. Morton DJ, Barrett-Connor EL, Schneider DL. Nonsteroidal anti-inflammatory drugs and bone mineral density in older women: the Rancho Bernardo study. J Bone Miner Res 1998;13: 1924-31.
8. Lane NE, Bauer DC, Nevitt MC, Pressman AR, Cummings SR, and the Study of Osteoporotic Fractures Research Group. Aspirin and nonsteroidal antiinflammatory drug use in elderly women: effects on a marker of bone resorption. J Rheumatol 1997;24: 1132-6.
9. Wimalawansa S, Chapa T, Fang L, Yallampalli C, Simmons D, Wimalawansa S. Frequency-dependent effect of nitric oxide donor nitroglycerin on bone. J Bone Miner Res 2000;15:1119-25.
10. Wallace JL, Reuter B, Cicala C, McKnight W, Grisham M, Cirino G. A diclofenac derivative without ulcerogenic properties. Eur J Pharmacol 1994;257:249-55.
11. Davies NM, Roseth AG, Appleyard CB, McKnight W, del Soldato P, Calignano A, et al. NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects. Aliment Pharmacol Ther 1997;11:69-79.
12. van 't Hof RJ, Ralston SH. Cytokinc-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast activity. J Bone Miner Res 1997;12: 1797-804.
13. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, et al. Osteoblastic cells are involved in osteoclast formation. Endocrinology 1988;123:2600-2.
14. MacPherson H, Noble BS, Ralston SH. Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells. Bone 1999;24:179-85.
15. Parfitt AM. Bone histomorphometry: standardization of nomenclature, symbols and units. Summary of proposed system. Bone Miner 1988;4:1-5.
16. Doggett NS, Jawaharlal K. Anorectic activity of prostaglandin precursors. Br J Pharmacol 1977;60:417-23.
17. Ralston SH. The Michael Mason Prize Essay 1997. Nitric oxide and bone: what a gas! Br J Rheumatol 1997;36:831-8.
18. Jamal SA, Browner WS, Bauer DC, Cummings SR. Intermittent use of nitrates increases bone mineral density: the study of osteoporotic fractures. J Bone Miner Res 1998;13:1755-9.
19. Wimalawansa SJ, Chapa MT, Yallampalli C, Zhang R, Simmons DJ. Prevention of corticosteroid-induced bone loss with nitric oxide donor nitroglycerin in male rats. Bone 1997;21:275-80.
20. Cirino G, Wheeler-Jones CP, Wallace JL, del Soldato P, Baydoun AR. Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties. Br J Pharmacol 1996;117:1421-6.
21. Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, et al. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 1997;11:3482-96.
22. Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R. Ostepetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 1997;3:1285-9.
23. Minto M, del Soldato P, Ghezzi P, Fratelli M. A novel acetylsalycilic acid nitroderivative inhibits NFκB activation and is antiproliferative to L929 cells [abstract]. Inflamm Res 1997;46 Suppl:253.
24. Gowen M, Mundy GR. Actions of recombinant interleukin-1, interleukin-2 and interferon gamma on bone resorption in vitro. J Immunol 1986;136:2478-82.
25. Boyce BF, Aufdemorte TB, Garret IR, Yates AJP, Mundy GR. Effects of interleukin-1 on bone turnover in normal mice. Endocrinology 1989;125:1142-50.
26. Okada Y, Lorenzo JA, Freeman AM, Tomita M, Morham SG, Raisz LG, et al. Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture. J Clin Invest 2000;105:823-32.
27. Li X, Okada Y, Pilbeam CC, Lorenzo JA, Kennedy CR, Breyer RM, et al. Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro. Endocrinology 2000;141: 2054-61.
28. Wallace JL, Reuter B, Cicala C, McKnight W, Grisham MB, Cirino G. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 1994;107:173-9.
29. Compston JE, Crawley EO, Evans C, O'Sullivan MM. Spinal trabecular bone mineral content in patients with non-steroid treated rheumatoid arthritis. Ann Rheum Dis 1988;47:660-4.
30. Sambrook PN, Reeve J. Bone disease in rheumatoid arthritis. Clin Sci (Colch) 1988;74:225-30.