Androgens and the ageing male

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 18, Issue 3, 2004, Pages 349-362

  Swerdloff, Ronald S ^a   Wang, Christina ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Ageing; Bone; Cardiovascular; Cognition; Erectile function; Libido; Mood; Muscle; Prostate; Testosterone

Indexed keywords

ESTRADIOL; GONADORELIN; SEX HORMONE BINDING GLOBULIN; SILDENAFIL; TESTOSTERONE; TESTOSTERONE CIPIONATE; TESTOSTERONE ENANTATE; TESTOSTERONE UNDECANOATE;

ADULT; AGED; AGING; BONE DENSITY; BONE MINERAL; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COGNITION; DISEASE EXACERBATION; EDEMA; ERECTILE DYSFUNCTION; ERYTHROCYTOSIS; FLUID RETENTION; FRAGILITY FRACTURE; HORMONE DEFICIENCY; HUMAN; HYPOGONADISM; LEYDIG CELL; MALE; MUSCLE MASS; MUSCLE STRENGTH; NONHUMAN; POLYCYTHEMIA; PROSTATE CANCER; PROSTATE HYPERTROPHY; REVIEW; RISK BENEFIT ANALYSIS; SEXUAL BEHAVIOR; SIDE EFFECT; SLEEP APNEA SYNDROME; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE; TESTOSTERONE SYNTHESIS; WEIGHT GAIN;

EID: 3342966112     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beem.2004.03.011     Document Type: Article

References (91)

1. Swerdloff R.S. Wang C. Endocrine system changes in the ageing male in: Lunenfeld B. Gooren L. eds. Textbook of Men's Health 2002 143-147 Parthenon Publishing Group New York
2. Bremner W.J. Vitiello M.V. Prinz P.N. Loss of circadian rhythmicity in blood testosterone levels with ageing in normal men Journal of Clinical Endocrinology and Metabolism 56 1983 1278-1281
3. Tenover J.S. Matsumoto A.M. Clifton D. Bremner W.J. Age-related alterations in the circadian rhythms of pulsatile luteinizing hormone and testosterone secretion in healthy men Journal of Gerontology 43 1988 M163-M169
4. Wang C. Catlin D.H. Demers L.M. Swerdloff R.S. Measurement of serum total testosterone in adult men: comparison of current laboratory methods versus liquid chromatography tandem mass spectrometry Journal of Clinical Endocrinology and Metabolism 89 2004 534-543
5. Vermeulen A. Verdonck A. Kaufman J.M. A critical evaluation of simple methods for estimation of free testosterone in serum Journal of Clinical Endocrinology and Metabolism 84 1999 3666-3672
6. Winter S.J. Kelley D.E. Goodpaster B. The analog free testosterone assay: are the results in men clinically useful Clinical Chemistry 44 1999 2178-2182
7. Vermeulen A. Androgen replacement therapy in the ageing male-a critical evaluation Journal of Clinical Endocrinology and Metabolism 86 2001 2380-2390
8. Snyder P.J. Effects of age on testicular function and consequences of testosterone treatment Journal of Clinical Endocrinology and Metabolism 86 2001 2369-2372
9. Harman M. Metter E.J. Tobin J.D. Pearson J. Blackman M.R. Longitudinal effects of ageing on serum total and free testosterone levels in healthy men Journal of Clinical Endocrinology and Metabolism 86 2001 724-731
10. Gray A. Feldman H.A. McKinlay J.B. Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study Journal of Clinical Endocrinology and Metabolism 73 1991 1016-1025
11. Feldman H.A. Longcope C. Derby C.A. et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male Aging Study Journal of Clinical Endocrinology and Metabolism 87 2002 589-598
12. Dai W.S. Kuller L.H. LaPorte R.E. et al. The epidemiology of plasma testosterone levels in middle-aged men American Journal of Epidemiology 114 1981 804-816
13. Ferrini R.L. Barrett-Connor E. Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men American Journal of Epidemiology 147 1998 750-754
14. Morley J.E. Kaiser F.E. Perry H.M.III et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men Metabolism 46 1997 410-413
15. Swerdloff R.S. Bhasin S. Blackman M. et al. Summary of the consensus session from the Second Annual Andropause Consensus 2001 Meeting 2001 Endocrine Society
16. Vermeulen A. Verdonck L. Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum Journal of Clinical Endocrinology and Metabolism 84 1999 3666-3672
17. Nilsson P. Moller L. Solkad K. Adverse effects of psychosocial stress on gonadal function and insulin levels in middle aged males Journal of Internal Medicine 237 1995 479-486
18. Morley J.E. Perry H.M. Kaiser F.E. et al. Effect of testosterone replacement therapy in old hypogonadal males: a preliminary study Journal of American Geriatric Society 41 1993 149-152
19. Hajjar R.R. Kaiser F.E. Morley J.E. Outcomes of long-term testosterone replacement therapy in older hypogonadal males: a retrospective study Journal of Clinical Endocrinology and Metabolism 82 1997 3793-3796
20. Buena F. Swerdloff R.S. Steiner B.S. et al. Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range Fertility and Sterility 59 1993 1118-1123
21. Christiansen K. Behavioral correlates of testosterone in: Nieschlag E. Behre H.M. eds. Testosterone: Action, Deficiency, Substitution 1998 107-131 Springer Berlin
22. Bacon C.B. Mittleman M.A. Kawachi I. et al. Sexual function in men older than 50 years of age: results from the health professionals follow-up study Annals of Internal Medicine 139 2003 161-168
23. NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases). Erectile Dysfunction. [Online]. Available at: http://www.niddk.nih.gov/health/orolo/pubs/impotnce/impotnce.htm accessed April 2003
24. Marin P. Testosterone, again, and body composition in: Lunenfeld B. Gooren L. eds. Textbook of Men's Health 2002 227-240 Parthenon Publishing Boca Raton, FL
25. Frontera W.R. Hughes V.V. Fiatarone M.A. Fielding R.A. Ageing and skeletal muscle: a 12 year longitudinal study Journal of Applied Physiology 88 2000 1321-1326
26. Reed R.L. Pearlmutter L. Jochum K. Meredith K.E. Mooradian A.D. The relationship between muscle mass and muscle strength in the elderly Journal of the American Geriatric Society 39 1991 555-591
27. Bhasin S. Buckwalter J.G. Testosterone supplementation in older men: a rational idea whose time has not yet come Journal of Andrology 22 2001 718-731
28. Roubenoff R. Grinspoon S. Skolnik P.R. et al. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men American Journal of Physiology-Endocrinology and Metabolism 283 2002 E138-E145
29. Vermeulen A. Goemaere S. Kaufman J.M. Sex hormones, body composition and ageing The Aging Male 2 1999 8-15
30. Tchernof A. Labrie F. Belanger A. et al. Relationships between endogenous sex steroid hormones, sex hormone binding globulin and lipoprotein levels in men contribution of visceral obesity, insulin levels and other metabolic variables Atherosclerosis 133 1997 235-244
31. Griggs R.C. Kingston W. Josefowicz R.F. et al. Effect of testosterone on muscle mass and muscle protein synthesis Journal of Applied Physiology 66 1989 498-503
32. Urban R.J. Bodenburg C. Gilkison C. et al. Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis American Journal Physiology 269 1995 E820-E826
33. Brodsky I.G. Balagogal P. Nair K.S. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men-a clinical research center study Journal of Clinical Endocrinology and Metabolism 81 1996 3469-3475
34. van den Beld A.W. de Jong F.H. Grobbee D.E. Pols H.A.P. Lamberts S.W.J. Measures of bio-available serum testosterone and estradiol and their relationship with muscle strength, bone density and body composition in elderly men Journal of Clinical Endocrinology Metabolism 85 2000 3276-3282
35. Baumgartner R.N. Waters D.L. Gallagher D. Morley J.E. Garry P.J. Predictors of skeletal muscle mass in elderly men and women Mechanisms in Aging Development 107 1999 123-136
36. Wang C. Swerdloff R.S. Iranmanesh A. et al. Transdermal testosterone gel improves sexual function, mood, muscle, strength, and body composition parameters in hypogonadal men Journal of Clinical Endocrinology and Metabolism 85 2000 2839-2853
37. Salehian B. Wang C. Alexander G. et al. Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparing to testosterone enanthate Journal of Clinical Endocrinology and Metabolism 80 1995 3567-3575
38. Bhasin S. Storer T.W. Berman N. et al. A replacement dose of testosterone increases muscle mass and size in hypogonadal men Journal of Clinical Endocrinology and Metabolism 82 1997 407-413
39. Tenover J.S. Effects of testosterone supplementation in the ageing male Journal of Clinical Endocrinology and Metabolism 75 1992 1092-1098
40. Sih R. Morley J.E. Kaiser F.E. Perry H.M.3rd Patrick P. Ross C. Testosterone replacement in older hypogonadal men: a 12 month randomized controlled study Journal of Clinical Endocrinology Metabolism 82 1997 1661-1667
41. Snyder P.J. Peachy H. Hannoush P. et al. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age Journal of Clinical Endocrinology and Metabolism 84 1999 2647-2653
42. Marin P. Holmang S. Gustafson C. et al. Androgen treatment of abdominally obese men Obesity Research 1 1993 245-248
43. Amory J.K. Chansky H.A. Chansky K.L. et al. Preoperative supraphysiologic testosterone in older men undergoing knee replacement surgery Journal of the American Geriatrics Society 50 2002 1698-1701
44. Kenny A.M. Bellatonio S. Gruman C.A. et al. Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 57 2002 M321-M325
45. English K.M. Steeds R.P. Jones T.H. et al. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study Circulation 102 2000 1906-1911
46. Bakhshi V. Eliott M. Gentili A. et al. Testosterone improves rehabilitation outcomes in ill older men Journal of the American Geriatrics Society 48 2000 550-553
47. NIH (National Institutes of Health). Osteoporosis and related bone diseases national resource center. Fast Facts on Osteoporosis [Online]. Available: http://www.osteo.org accessed May 2003
48. NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases). Osteoporosis: Progress and Promise. [Online]. Available: http://www.niams.nih.gov/hi/topics/osteoporosis/opbkgr.htm accessed July 2003
49. Greendale G. Edelstein S. Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men. The Rancho Bernardo Study Journal of Bone and Mineral Research 12 1997 1833-1841
50. Khosla S. Melton L.J. Atkinson E.J. O-Fallon W.M. Klee G.G. Riggs B.L. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men: a key role for bio-available estrogen Journal of Clinical Endocrinology and Metabolism 83 1998 2266-2275
51. Finkelstein J.S. Androgens and bone metabolism in: Nieschlag E. Behre H.M. eds. Testosterone: Action, Deficiency, Substitution 1998 187-207 Springer Berlin
52. Wergdal J.E. Baylink D.J. Mechanism of action of androgens on bone cells in: Bhasin S. Gabelnick H.L. Spieler J.M. Swerdloff R.S. Wang C. Kelly C. eds. Pharmacology, Biology and Clinical Application of Androgens: Current Status and Future Prospects 1996 259-264 Wiley-Liss New York
53. Wang C. Swerdloff R.S. Iranmanesh A. et al. Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men Clinical Endocrinology 54 2001 739-750
54. Wang C. Alexander G. German N. et al. Testosterone replacement therapy improves mood in hypogonadal men-a clinical research center study Journal of Clinical Endocrinology and Metabolism 81 1996 3578-3583
55. Christmas C. O'Connor K.G. Harman S.M. et al. Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 57 2002 M12-M18
56. Kenny A.M. Prestwood K.M. Gruman C.A. et al. Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels Journal of Gerontology. Series A: Biological Sciences and Medical Sciences 56 2001 M266-M272
57. Snyder P.J. Peachey H. Hannoush P. et al. Effects of testosterone treatment on bone mineral density in men over 65 years old Journal of Clinical Endocrinology and Metabolism 84 1999 1966-1972
58. Alexander G.M. Androgens and cognitive function in: Bhasin S. Gabelnick H.L. Spieler J.M. Swerdloff R.S. Wang C. Kelly C. eds. Pharmacology, Biology, and Clinical Applications of Androgens: Current Status and Future Prospects 1996 169-177 Wiley-Liss New York
59. Frye C.A. Seliga A.M. Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats Cognitive, Affective and Behavioral Neuroscience 1 2001 371-381
60. Christiansen K. Kussmann R. Sex hormones and cognitive functions in men Neuropsychobiology 18 1987 27-36
61. McKeever W.F. Deyo A. Testosterone, dihydrotestosterone and spatial task performance of males Bulletin of the Psychonomic Society 28 1990 305-308
62. Cherrier M.M. Anawalt B.D. Herbst K.L. et al. Cognitive effects of short-term manipulation of serum sex steroids in healthy young men Journal of Clinical Endocrinology and Metabolism 87 2002 3090-3096
63. Janowski S.C. Oviatt S.K. Orwoll E.S. Testosterone influences spatial cognition in older men Behavior Neuroscience 108 1994 325-332
64. Barrett-Connor E. von Muhlen D.G. Kritz-Silverstein D. Bio-available testosterone and depressive mood in older men. The Rancho-Bernardo Study Journal of Clinical Endocrinology and Metabolism 84 1999 573-577
65. Pope H.G. Jr Cohane G.H. Kanayama G. et al. Testosterone gel supplementation for men with refractory depression: a randomized placebo-controlled trial American Journal of Psychiatry 160 2003 105-111
66. Rabkin J.G. Wagner G.J. Rabkin R. Testosterone therapy for human immunodeficiency virus-positive men with and without hypogonadism Journal of Clinical Psychopharmacology 19 1999 19-27
67. Matsumoto A.M. Andropause: clinical implications of the decline in serum testosterone levels with ageing in men Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 57 2002 M76-M99
68. Cauley J.A. Gutai J.P. Kuller L.H. Dai W.S. Usefulness of sex steroid hormone levels in predicting coronary artery disease in men American Journal of Cardiology 60 1987 771-777
69. Yarnell J.W. Beswick A.D. Sweetnam P.M. Riad-Fahmy D. Endogenous sex hormones and ischemic heart disease in men. The Caerphilly prospective study Arteriosclerosis and thrombosis 13 4 1993 517-520
70. Barrett-Connor E. Khaw K.T. Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study Circulation 78 1988 539-545
71. Bhasin S. Storer T.W. Asbel-Sethi N. et al. Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels Journal of Clinical Endocrinology and Metabolism 89 1998 3155-3162
72. Simon D. Charles M.A. Lahlou N. et al. Androgen therapy improves insulin sensitivity and decreases leptin level in health adult men with low plasma total testosterone: a 3-month randomized placebo-controlled trial Diabetes Care 24 2001 2149-2151
73. Blackman M.R. Sorkin J.D. Munzer T. et al. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial Journal of the American Medical Association 288 2002 2282-2292
74. Clague J.E. Wu F.C. Horan M.A. Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men International Journal of Andrology 22 1999 261-265
75. Drinka P.J. Jochen A.L. Cuisinier M. et al. Polycythemia as a complication of testosterone replacement therapy in nursing home men with low testosterone levels Journal of the American Geriatrics Society 43 1995 899-901
76. Ferrando A.A. Sheffield-Moore M. Yeckel C.W. et al. Testosterone administration to older men improves muscle function: molecular and physiological mechanisms American Journal of Physiology-Endocrinology and Metabolism 282 2002 E601-E607
77. Uyanik B.S. Ari Z. Gumus B. et al. Beneficial effects of testosterone undecanoate on the lipoprotein profiles in healthy elderly men: a placebo-controlled study Japanese Heart Journal 28 1997 73-82
78. Kenny A.M. Prestwood K.M. Gruman C.A. et al. Effects of transdermal testosterone on lipids and vascular reactivity in older men with low bioavailable testosterone levels Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 57 2002 M460-M465
79. Bagatell C.J. Heiman J.R. Matsumoto A.M. et al. Metabolic and behavioral effects of high-dose, exogenous testosterone in health men Journal of Clinical Endocrinology and Metabolism 79 1994 561-567
80. Meriggiola M.C. Marcovina S. Paulsen C.A. Bremner W.J. Testosterone enanthate at a dose of 200 mg/week decreases HDL-cholesterol levels in healthy men International Journal of Andrology 18 1995 237-242
81. Anderson F.H. Francis R.M. Faulkner K. Androgen supplementation in eugonadal men with osteoporosis-effects of 6 months of treatment on bone mineral density and cardiovascular risk factors Bone 18 1996 171-177
82. Tenover J.L. Risks and benefits of testosterone in older men in: Robarire B. Chemes H. Morales C.R. eds. Andrology in the 21st Century 2001 395-405 Medimond Montreal
83. Thompson P.D. Ahlberg A.W. Moyna N.M. et al. Effect of intravenous testosterone on myocardial ischemia in men with coronary artery disease American Heart Journal 143 2002 249-256
84. NCI (National Cancer Institute). Prevention of prostate cancer. [Online]. Available at: http://www.nic.nih.gov/cancerinfo/pdq/ prevention/prostate/healthprofessional [accessed April 2003]
85. Bhasin S. Singh A.B. Mac R.P. et al. Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan Journal of Andrology 24 2003 299-311
86. Shaneyfelt T. Husein R. Bubley G. Mantzoros C.S. Hormonal predictors of prostate cancer: a meta-analysis Journal of Clinical Oncology 18 2000 847-853
87. Schatzl G. Madersbacher S. Thurridl T. et al. High-grade prostate cancer is associated with low serum testosterone levels Prostate 47 2001 52-58
88. Massengill J.C. Sun L. Moul J.W. et al. Pretreatment total testosterone level predicts pathological stage in patients with localized prostate cancer treated with radical prostatectomy Journal of Urology 169 2003 1670-1675
89. Prehn R.T. On the prevention and therapy of prostate cancer by androgen administration Cancer Research 59 1999 4161-4164
90. IOM (Institute of Medicine) Testosterone in aging, clinical research directions Liverman C.T. Blazer D.G. 2004 National Academies Press Washington DC
91. Cunningham G.R. Overview of androgens on the normal and abnormal prostate Bhasin S. Gabelnick H.L. Spieler J.M. Swerdloff R.S. Wang C. Kelly C. Pharmacology, Biology, and Clinical Application of Androgens: Current Status and Future Prospects 1996 187-207 Wiley-Liss New York