Sex hormones, body composition and aging

Aging Male

Volumn 2, Issue 1, 1999, Pages 8-15

  Vermeulen, A ^a   Goemaere, S ^a   Kaufman, J M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Abdominal fat; Aging; Body fat mass; Muscle mass; Sex hormones; Testosterone; Visceral fat

Indexed keywords

ESTRADIOL; INSULIN; SOMATOMEDIN C; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; BODY FAT; BODY MASS; ESTRADIOL BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; MALE; MUSCLE MASS; OBESITY; PRIORITY JOURNAL; SUBCUTANEOUS FAT; TESTOSTERONE BLOOD LEVEL;

EID: 0032977299     PISSN: 13685538     EISSN: None     Source Type: Journal    
DOI: 10.3109/13685539909003178     Document Type: Article

References (49)

1. 1. Katznelson L, Finkelstein JS, Schoenfeld AA, Rosenthal DI, Anderson EJ, Klibanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81: 4358-65
2. 2. Carlson KE, Alston W, Feldman DJ. Electromyographic study of aging in skeletal muscle. Am J Phys Med 1964;43:141-5
3. 3. Forbes GB, Reina JC. Adult lean body mass declines with age. Some longitudinal observations. Metabolism 1970;19:653-63
4. 4. Novak LP. Ageing, total body potassium, fat free mass and cell mass in males and females between ages 18 and 65 years. J Gerontol 1972;27;437-43
5. 5. Shimokata H, Tobin, JD, Muller DC, Elahi D, Coon RJ, Andres R. Studies in the distribution of body fat. 1. Effects of age, sex and obesity. J Gerontol Med Sci 1989;44:M66-73
6. 6. Swerloff RJ, Wang C. Androgens and aging in men. Exp Gerontol 1993;28:435-46
7. 7. Tenover SS. Androgen administration to aging men. Endocrinol Metab Clin 1994;23:877-89
8. 8. Vermeulen A, Stoica T, Verdonck L. The apparent free testosterone concentration - an index of androgenicity. J Clin Endocrinol Metab 1971;33: 759-63
9. 9. Kirschner MA, Samoljik E, Drejka M, Szmal E, Schneider GH, Ertel N. Androgen-estrogen metabolism in women with upper body versus lower body obesity. J Clin Endocrinol Metab 1990; 70:473-9
10. 10. Shimokata M, Andres R, Coon PJ, Elahi D, Muller DC, Tobin JD. Studies in the distribution of body fat. II. Longitudinal effects of changes in weight. Int J Obes 1989;13:455-64
11. 11. Killinger DW, Perel E, Danilesen D, Kharlip L, Lindsay WRV. Influence of adipose tissue distribution on the biological activity of androgens. Ann N Y Acad Sci 1990;5:191-211
12. 12. Harman SM, Tsitouras PD. Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 1980;51:35-40
13. 13. Longcope C. The effect of human chorionic gonadotropin on plasma steroid levels in young and old men. J Clin Endocrinol Metab 1973;21: 583-92
14. 14. Nieschlag E, Lammers V, Freichem CW, Langer K, Wickings EJ. Reproductive function in young fathers and grandfathers. J Clin Endocrinol Metab 1982;55:676-81
15. 15. Zumoff B, Strain GW, Kream J. Age variation of the 24 hour mean plasma concentration of androgens, estrogens and gonadotropins in normal adult men. J Clin Endocrinol Metab 1982;545:534-8
16. 16. Greenblatt RB, Oettinger M, Bohler CSS. Estrogen-androgen levels in aging men and women: therapeutic considerations. J Am Geriatr Soc 1976;24:173-6
17. 17. Hemsel DL, Grodin JM, Bremner PF, Siiteri PK, MacDonald PC. Plasma precursors of estrogens, II. Correlation of the extent of conversion of plasma androstenedione to estrone with age. J Clin Endocrinol Metab 1974;38:476-85
18. 18. Pirke KM, Doerr P. Age related changes in free plasma testosterone, dihydrotestosterone, estradiol and testosterone binding globulin in normal adult males. Acta Endocrinol (Copenh) 1975;80:171-8
19. 19. van den Beld AW, Grobbee DE, Pols HAP, Lamberts SWJ. The role of estrogen in physical and psychological well-being in elderly men. Aging Male 1998;1(Suppl 1):abstr 106
20. 20. Kissebah AH, Evans DJ, Peiris A, Wilson CR. Endocrine characteristics in regional obesities: role of sex steroids. In Vague JK, Björndorp Gury, Grand B, eds. Metabolic Complications of Human Obesities. Amsterdam: Elsevier Science Publishers, 1985:115-30
21. 21. Sparrow D, Borkan GA, Gerzof SG, Wisnewski C, Silbert K. Relationship of computed tomography in male participants of the normative age study. Diabetes 1986;35:411-15
22. 22. Seidell JC, Björntorp P, Sjöström L, Kvist H, Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose and C-peptide levels and negatively with testosterone levels. Metab Clin Exp 1990;39:897-901
23. 23. Seidell JC, Oosterlee A, Deurenberg P, Hautvast JGAJ, Ruys JHJ. Abdominal fat depots measured with computed tomography: effects of degree of obesity, sex and age. Eur J Clin Nutr 1988;42: 805-13
24. 24. Shephard RJ. Physical Activity and Aging. London: Groom Helm, 1978:193-6
25. 25. Rudman D, Drinka PJ, Wilson CR, Mattson DE, Schermaus F, Cuisinier Mc, et al. Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol 1994;40:653-61
26. 26. Vermeulen A. Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin C levels. J Clin Endocrinol Metab 1987;64:884-8
27. 27. Iranmanesh A, Lazzarilde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half life of endogenous GH in healthy men. J Clin Endocrinol Metab 1991;73:1081-8
28. 28. Jörgensen JOL, Vahl N, Hansen TB, Thuesen L, Hagen C, Christiansen JS. Growth hormone versus placebo treatment for one year in growth hormone deficient adults: increase in exercise capacity and normalisation of body composition. Clin Endocrinol 1996;45:681-8
29. 29. Fryburg DA, Barrett E. Growth hormone acutely stimulates skeletal muscle but not whole body protein synthesis in humans. Metabolism 1993;42: 1222-7
30. 30. Sartorio A, Narici MV. Growth hormone (GH) treatment in GH deficient adults: effects on muscle size, strength and neural activation. Clin Physiol 1994;14:527-37
31. 31. Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormone binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 1996; 81:1821-6
32. 32. Glass AR. Endocrine aspects of obesity. Med Clin North Am 1989;73:139-60
33. 33. Frystyk J, Vestbo E, Skjaerbaek C, Mogensen CE, Orskov H. Free insulin-like growth factor in human obesity. Metabolism 1995;44:37-44
34. 34. Ho KY, Weissberger AJ. Secretory patterns of growth hormone according to age and sex. Horm Res 1990;33(Suppl 4):7-11
35. 35. Märin P, Krotkiewski M, Björntorp P. Androgen treatment of middle aged obese men: effects on metabolism of adipose tissues. Eur J Med 1992;1: 329-36
36. 36. Märin P, Holmäng S, Gustafsson C, Jönsson L, Kvist H, Elander A, et al. Androgen treatment of abdominally obese men. Obesity Res 1993;1:245-9
37. 37. Tchernof A, Labrie F, Bélanger A, Prud'homme D, Bouchard A, Tremblay A, et al. Relationships between endogenous steroid hormones, sex hormone binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables. Atherosclerosis 1997; 133:235-44
38. 38. Brodsky I, Balagopal P, Nair SK. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men. A clinical research center study. J Clin Endocrinol Metab 1996; 81:3469-74
39. 39. Wang C, Eyre DR, Clark R, Kleinberg D, Newman C, Iranmanesh A, et al. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption and increases bone formation markers in hypogonadal men. A clinical research center study. J Clin Endocrinol Metab 1996;81:3654-62
40. 40. Bhasin S, Storer TW, Berman N, Yarasheski RE, Clevenger B, Phillips J, et al. Testosterone replacement increases fat free mass and muscle size in hypogonadal men. J Clin Endocrinol Metab 1997;82: 407-13
41. 41. Marin P, Holmäng S, Jönsson L, Sjöstrom L, Kvist H, Holm G, et al. The effects of testosterone treatment on body composition and metabolism in middle aged men. Int J Obesity 1992;16;991-7
42. 42. Morley JE, Perry HM, Kaiser FE, Kraenzle D, Jensen J, Houston K, et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 1993;41: 149-52
43. 43. Sih R, Morley JE, Kaiser FE, Perry HM III, Patrick P, Ross C. Testosterone replacement in older hypogonadal men: a 12 month randomized controlled trial. J Clin Endocrinol Metab 1997;82: 1661-7
44. 44. Tenover JS. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992;75:1092-8
45. 45. Bhasin S, Storer TW, Berman N, Calligari C, Clevenger B, Phillips S, et al. The effect of supra-physiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 1996;335: 1-7
46. 46. Alen M, Rahkila M, Vihko R. Response of serum hormones to androgen administration in power athletes. Med Sci Sports Med 1985;17:354-9
47. 47. Xu X, De Pergola G, Björntorp P. The effects of androgens on the regulation of lipolysis in adipose tissue cells. Endocrinology 1990;126:1229-34
48. 48. von Eckhardstein A. Androgens, cardiovascular risk factors and atherosclerosis. In Nieschlmag E, Behre HM, eds. Testosterone, Action, Deficiency, Substitution, 2nd edn. Berlin: Springer, 1998:229-57
49. 49. Marin P, Oden B, Björntorp P. Assimilation and mobilisation of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men. Clin Endocrinol Metab 1995;80:239-43