Toxicogenomic approach to endocrine disrupters: Identification of a transcript profile characteristic of chemicals with estrogenic activity

Toxicologic Pathology

Volumn 32, Issue SUPPL. 2, 2004, Pages 59-70

  Naciff, Jorge M ^a   Daston, George P ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

17 ethynyl estradiol; Bisphenol A; Endocrine disrupters; Gene expression profiling; Genistein; Microarrays; Reproductive system of the female rat; Uterotrophic assay

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ACTIN; ALDEHYDE DEHYDROGENASE; CALCIUM BINDING PROTEIN; CARCINOEMBRYONIC ANTIGEN; CREATINE KINASE; CYTOKERATIN 18; DESMIN; DRINKING WATER; ETHINYLESTRADIOL; FC RECEPTOR; FIBRONECTIN; GENISTEIN; GLUTATHIONE TRANSFERASE; GUANINE DEAMINASE; HEAT SHOCK PROTEIN 27; HYDROXYSTEROID DEHYDROGENASE; METALLOTHIONEIN; PESTICIDE; SOMATOMEDIN BINDING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; COST; DNA MICROARRAY; EMBRYOTOXICITY; ENDOCRINE FUNCTION; ENVIRONMENTAL EXPOSURE; ESTROGEN ACTIVITY; FEMALE; FETOTOXICITY; FOOD CONTAMINATION; GENE EXPRESSION PROFILING; GENOTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; TOXICITY TESTING; UNITED STATES; WATER CONTAMINATION;

ANIMALS; ENDOCRINE SYSTEM; ESTRADIOL; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; GENISTEIN; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOLS; RATS; TRANSCRIPTION, GENETIC; UTERUS; XENOBIOTICS;

ANIMALIA;

EID: 3342931244     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230490463812     Document Type: Conference Paper

References (32)

1. Agnihotri, R., Crawford, H. C., Haro, H., Matrisian, L. M., Havrda, M. C., and Liaw, L. (2001). Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). J Biol Chem 276, 28261-7.
2. Apparao, K. B., Murray, M. J., Fritz, M. A., Meyer, W. R., Chambers, A. F., Truong, P. R., and Lessey, B. A. (2001). Osteopontin and its receptor alphavbeta (3) integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab 86, 4991-5000.
3. Ashby, J., and Tinwell, H. (1998). Uterotrophic activity of bisphenol A in the immature rat. Environ Health Perspect 106, 719-20.
4. Ashkar, S., Weber, G. F., Panoutsakopoulou, V., Sanchirico, M. E., Jansson, M., Zawaideh, S., Rittling, S. R., Denhardt, D. T., Glimcher, M. J., and Cantor, H. (2000). Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 287, 860-4.
5. Branham, W. S., Zehr, D. R., Chen, J. J., and Sheehan, D. M. (1988). Alterations in developing rat uterine cell populations after neonatal exposure to estrogens and antiestrogens. Teratology 38, 271-9.
6. Couse, J. F., Lindzey, J., Grandien, K., Gustafsson, J. A., and Korach, K. S. (1997). Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERa-knockout mouse. Endocrinology 138, 4613-21.
7. Diel, P., Schulz, T., Smolnikar, K., Strunck, E., Vollmer, G., and Michna, H. (2000). Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity. J Steroid Biochem Mol Biol 73, 1-10.
8. Gong, X. Q., and Li, L. (2002). Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. J Biol Chem 277, 12310-7.
9. Gunther, E. C., Stone, D. J., Gerwien, R. W., Bento, P., and Heyes, M.P. (2003). Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro. Proc Natl Acad Sci USA 100, 9608-13.
10. Hall, J. M., Couse, J. F., and Korach, K. S. (2001). The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276, 36869-72.
11. Hamadeh, H. K., Bushel, P. R., Jayadev, S., DiSorbo, O., Bennett, L., Li, L., Tennant, R., Stoll, R., Barrett, J. C., Paules, R. S., Blanchard, K., and Afshari, C. A. (2002a). Prediction of compound signature using high density gene expression profiling. Toxicol Sci 67, 232-40.
12. Hamadeh, H. K., Bushel, P. R., Jayadev, S., Martin, K., DiSorbo, O., Sieber, S., Bennett, L., Tennant, R., Stoll, R., Barrett, J. C., Blanchard, K., Paules, R. S., and Afshari, C. A. (2002b). Gene expression analysis reveals chemical-specific profiles. Toxicol Sci 67, 219-31.
13. Klinge, C. M. (2001). Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 29, 2905-19.
14. Lee, M. S., Lowe, G., Flanagan, S., Kuchler, K., and Glackin, C. A. (2000). Human Dermo-1 has attributes similar to twist in early bone development. Bone 27, 591-602.
15. Liaw, L., Birk, D. E., Ballas, C. B., Whitsitt, J. S., Davidson, J. M., and Hogan, B. L. (1998). Altered wound healing in mice lacking a functional osteopontin gene (sppl). J Clin Invest 101, 1468-78.
16. Lockhart, D. J., Dong, H., Byrne, M. C., Follettie, M. T., Gallo, M. V., Chee, M. S., Mittmann, M., Wang, C., Kobayashi, M., Horton, H., and Brown, E. L. (1996). Expression monitoring by hybrydization to high-density oligonucleotide arrays. Nat Biotechnol 14, 1675-80.
17. McLachlan, J. A., and Newbold, R. R. (1987). Estrogens and development. Environ Health Perspect 75, 25-7.
18. Morimoto, I., Sasaki, Y., Ishida, S., Imai, K., and Tokino, T. (2002). Identification of the osteopontin gene as a direct target of TP53. Genes Chromosomes Cancer 33, 270-8.
19. Naciff, J. M., Jump, M. L., Torontali, S. M., Carr, G. J., Tiesman, J. P., Overmann, G. J., and Daston, G. P. (2002). Gene expression profile induced by 17 α-ethynyl estradiol, bisphenol a, and genistein in the developing female reproductive system of the rat. Toxicol Sci 68, 184-99.
20. Naciff, J. M., Overmann, G. J., Torontali, S. M., Carr, G. J., Tiesman, J. P., Richardson, B. D., and Daston, G. P. (2003). Gene expression profile induced by 17 alpha-ethynyl estradiol in the prepubertal female reproductive system of the rat. Toxicol Sci 72, 314-30.
21. Nilsson, S., Makela, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., and Gustafsson, J. A. (2001). Mechanisms of estrogen action. Physiol Rev 81, 1535-65.
22. Noda, S., Sawaki, M., Shiraishi, K., Yamasaki, K., and Yamaguchi, R. (2002). Age-related changes of genital systems in the female Crj:CD (SD) IGS rats during sexual maturation. J Vet Med Sci 64, 315-9.
23. Nuwaysir, E. F., Bittner, M., Trent, J., Barrett, J. C., and Afshari, C. A. (1999). Microarrays and toxicology: the advent of toxicogenomics. Mol Carcinogensis 24, 153-9.
24. Riggs, B. I., and Hartmann, L. C. (2003). Selective estrogen-receptor modulators mechanisms of action and application to clinical practice. N Engl J Med 348, 618-29.
25. Shang, Y., and Brown, M. (2002). Molecular determinants for the tissue specificity of SERMs. Science 295, 2465-8.
26. Steiner, S., and Anderson, N. L. (2000). Expression profiling in toxicology: potential and limitations. Toxicol Lett 112-113, 467-71.
27. Tamura, M., and Noda, M. (1999). Identification of DERMO-1 as a member of helix-loop-helix type transcription factors expressed in osteoblastic cells. J Cell Biochem 72, 167-76.
28. Thigpen, J. E., Setchell, K. D., Ahlmark, K. B., Locklear, J., Spahr, T., Caviness, G. F., Goelz, M. F., Haseman, J. K., Newbold, R. R., and Forsythe, D. B. (1999). Phytoestrogen content of purified, open- and closed-formula laboratory animal diets. Lab Anim Sci 49, 530-6.
29. Toorop, A. I., Meijs-Roelofs, H. M., Kramer, P., and de Greef, W. J. (1984). Ovarian steroid concentrations in rats approaching first ovulation. J Endocrinol 100, 281-6.
30. U. S. Environmental Protection Agency (1998). USA Environmental Protection Agency. Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC). Final Report Chapter 5: Screening and Testing. (http://www.epa.gov/ scipoly/oscpendo/history/finalrpt.htm).
31. vom Saal, F. S., Timms, B. G., Montano, M. M., Palanza, P., Thayer, K. A., Nagel, S. C., Dhar, M. D., Ganjam, V. K., Parmigiani, S., and Welshons, W. V. (1997). Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 94, 2056-61.
32. Yu, W. H., Woessner, J. F. Jr, McNeish, J. D., and Stamenkovic, I. (2002). CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev 16, 307-23.