Effects of acute and chronic treatment with the sodium hydrogen exchanger 1 (NHE-1) inhibitor cariporide on myocardial infarct mass in rabbits with hypercholesterolaemia

Basic and Clinical Pharmacology and Toxicology

Volumn 95, Issue 1, 2004, Pages 24-30

  Jung, Oliver ^a   Albus, Udo ^b   Lang, Hans Jochen ^b   Busch, Andreas E ^b   Linz, Wolfgang ^b  

^a GOETHE UNIVERSITY   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CARIPORIDE; CHOLESTEROL; COCONUT OIL; SODIUM PROTON EXCHANGE PROTEIN 1;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM CELL; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEMODYNAMICS; HYPERCHOLESTEROLEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; AORTA, THORACIC; CHOLESTEROL; DIET, ATHEROGENIC; DRUG ADMINISTRATION SCHEDULE; GUANIDINES; HYPERCHOLESTEROLEMIA; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; PAPILLARY MUSCLES; RABBITS; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 3342896429     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2004.t01-1-pto950105.x     Document Type: Article

References (37)

1. Avkiran, M.: Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia. Amer. J. Cardiol. 1999, 83, 10G-17G.
2. + exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J. Amer. Coll. Cardiol. 2002, 39, 747-753.
3. Becker, R. H. A., G. Wiemer & W. Linz: Preservation of endothelial function by ramipril in rabbits on a long-term atherogenic diet. J. Cardiovasc. Pharmacol. 1991, 18, S110-S115.
4. + exchange. J. Clin. Invest. 1989, 83, 822-829.
5. Birnbaum, Y., S. L. Hale & R. A. Kloner: Differences in reperfusion length following 30 min of ischemia in the rabbit influence infarct size, as measured by triphenyltetrazolium chloride staining. J. Mol. Cell. Cardiol. 1997, 29, 657-666.
6. + exchanger. Cardiovasc. Res. 2002a, 53, 862-868.
7. + exchanger induced by chronic treatment with a selective inhibitor. J. Mol. Cell. Cardiol. 2002b, 34, 1539-1547.
8. + exchanger inhibition: a new antihypertrophic tool. Circ. Res. 2002, 90, 751-753.
9. Creager, M. A., S. J. Gallagher, X. J. Girerd, S. M. Colemean, V. J. Dzau & J. P. Cooke: L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 1992, 90, 1248-1253.
10. Du, Z. Y. & O. L. Woodman: The effect of hypercholesterolemia and atherosclerosis on alpha-adrenoceptor-mediated vasoconstriction in conscious rabbits and rabbit aorta. Eur. J. Pharmacol. 1991, 11, 149-156.
11. 1-adrenergic receptor transgenic mice. Circ. Res. 2002, 90, 814-819.
12. + exchanger activity. Basic Res. Cardiol. 2001, 96, 301-305.
13. 1-adrenergic contractile responses in hypercholesterolemic rabbit common carotid arteries. J. Cardiovasc. Pharmacol. 1993, 22, 58-64.
14. + exchange isoform 1 mRNA expression in isolated rat hearts. Amer. J. Physiol. 1999, 277, H993-H998.
15. Granger, D. N.: Ischemia-reperfusion: mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation 1999, 6, 167-178.
16. + exchange inhibition prevents endothelial dysfunction after I/R injury. Amer. J. Physiol. 2001, 281, H1260-H1266.
17. Hartman, J. G., G. M. Kurc, T. G. Hullinger & T. M. Wall: Inhibition of nitric oxide synthase prevents myocardial protection by ramiprilat. J. Pharmacol. Exp. Therap. 1994, 270, 1071-1078.
18. Hoshida, S., M. Nishda, N. Yamashita, J. Igarashi, M. Hori, T. Kamada & T. Kuzuya: Amelioration of severity of myocardial injury by a nitric donor in rabbits fed a cholesterol rich diet. J. Amer. Coll. Cardiol. 1996, 27, 902-909.
19. Hoshida, S., N. Yamashita, K. Kawahara, T. Kuzuya & M. Hori: Amelioration by quinapril of myocardial infarction induced by coronary occlusion/reperfusion in a rabbit model of athersclerosis. Circulation 1999, 99, 434-440.
20. + exchange inhibition. Circ. Res. 2000, 87, 1133-1140.
21. Jung, O., W. Jung, T. Malinski, G. Wiemer, B. A. Schölkens & W. Linz: Ischemic preconditioning and infarct mass: the effect of hypercholesterolemia and endothelial dysfunction. Clin. Exp. Hypertens. 2000, 22, 165-179.
22. + exchange: structure, regulation, and its role in heart disease. Circ. Res. 1999, 85, 777-786.
23. Karmazyn, M.: Pharmacology and clinical assessment of Cariporide for the treatment of coronary artery disease. Exp. Opin. Invest. Drugs 2000, 9, 1099-1108.
24. + exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats. Amer. J. Physiol. 2001, 280, H738-H745.
25. Levine, G. N., J. F. Keaney & J. A. Vita: Cholesterol reduction in cardiovascular disease: clinical benefits and possible mechanisms, New Engl. J. Med. 1995, 332, 512-521.
26. Linz, W., U. Albus, P. Crause, W. Jung, A. Weichert, B. A. Schölkens & W. Scholz: Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642). Clin. Exp. Hypertens. 1998, 20, 733-749.
27. Lüscher, T. F.: Endothelial dysfunction in atherosclerosis. J. Myocard. Ischemia 1995, 7, 15-20.
28. März, W., R. Sieckmeier, H. Scharnagl, U. B. Seiffert & W. Gross: Fast lipoprotein chromatography: new method of analysis for plasma lipoproteins. Clin. Chem. 1993, 39, 2276-2281.
29. Myers, M. L., P. Farhangkhoee & M. Karmazyn: Hydrogen peroxide induced impairment of post-ischemic ventricular function is prevented by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Cardiovasc. Res. 1998, 40, 290-296.
30. 1-receptor expression. Amer. J. Physiol. 1997, 272, H2701-H2707.
31. 3-symporter. Eur. J. Pharmacol. 2003, 458, 3-16.
32. Scholz, W., U. Albus, L. Counillon, H. Gögelein, H.-J. Lang, W. Linz, A. Weichert & B. A. Schölkens: Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischemia and reperfusion. Cardiovasc. Res. 1995, 29, 260-268.
33. Schuh, J. R., D. J. Blehm, G. E. Frierdich, E. G. McMahon & E. H. Blaine: Differential effects of renin-angiotensin system blockade on atherogenesis in cholesterol-fed rabbits. J. Clin. Invest. 1993, 91, 1453-1458.
34. +-exchange inhibitor cariporide in infarct-induced heart failure. Cardiovasc. Res. 2000, 46, 102-110.
35. Szilvassy, Z., P. Ferdinandy, J. Szilvassy, I. Nagy, S. Karcsu, J. Lonovics, L. Dux & M. Koltai: The loss of pacing-induced preconditioning in atherosclerotic rabbits: role of hypercholesterolemia. J. Mol. Cell. Cardiol. 1995, 27, 2559-2569.
36. Touret, N., V. Tanneur, H. Godart, R. Seidler, N. Taki, E. Burger, J. Dammgen & L. Counillon: Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur. J. Pharmacol. 2003, 459, 151-158.
37. Vane, J. R., E. E. Änggard, R. M. Botting: Regulatory functions of the vascular endothelium. New Engl. J. Med. 1990, 323, 27-36.