Weaning of immunosuppression in liver transplant recipients

Transplantation

Volumn 63, Issue 2, 1997, Pages 243-249

  Mazariegos, George V ^a,b   Reyes, Jorge ^a   Marino, Ignazio R ^a   Demetris, Anthony J ^a   Flynn, Bridget ^a   Irish, William ^a   McMichael, John ^a   Fung, John J ^a   Starzl, Thomas E ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIBODY; OKT 3; PREDNISONE; TACROLIMUS;

ALLOGRAFT; ARTICLE; CLINICAL PROTOCOL; CORTICOSTEROID THERAPY; DRUG INDUCED DISEASE; DRUG WITHDRAWAL; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER FUNCTION TEST; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK BENEFIT ANALYSIS;

ADULT; ANALYSIS OF VARIANCE; AZATHIOPRINE; CHILD; CYCLOSPORINE; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; PREDNISONE; PREGNANCY; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; TACROLIMUS; TIME FACTORS;

EID: 0030899508     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199701270-00012     Document Type: Article

References (19)

1. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole organ transplantation: the basis of graft acceptance. Hepatology 1993; 17: 1127.
2. Mazariegos GV, Ramos H, Shapiro R, Zeevi A, Fung JJ, Starzl TE. Weaning of immunosuppression in long-term recipients of living-related renal transplants: a preliminary study. Transplant Proc 1995; 27: 207.
3. Ramos HC, Reyes J, Abu-Elmagd K, et al. Weaning of immunosuppression in long-term liver transplant recipients. Transplantation 1995; 59: 212.
4. Starzl TE, Iwatsuki S, Van Thiel DH, et al. Evolution of liver transplantation. Hepatology 1982; 2: 614.
5. Fung JJ, Todo S, Jain A, Demetris AJ, McMichael JP, Starzl TE: The Pittsburgh randomized trial of tacrolimus versus cyclosporine for liver transplantation. J Am Coll Surg 1996; 183: 117.
6. Demetris AJ, Fung JJ, Todo S, et al. Conversion of liver allograft recipients from cyclosporine to FK 506 immunosuppressive therapy - a clinicopathologic study of 96 patients. Transplantation 1992; 53: 1056.
7. van Hoek B, Wiesner RH, Krom RAF, Ludwig J, Moore SB. Severe ductopenic rejection following liver transplantation: incidence, time of onset, risk factors, treatment, and outcome. Semin Liver Dis 1992; 12: 41.
8. Starzl TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M. Cell migration, chimerism, and graft acceptance. Lancet 1992; 339: 1579.
9. Demetris AJ, Murase N, Fujisaki S, Fung JJ, Rao AS, Starzl TE. Hematolymphoid cell trafficking, microchimerism, and GVHD reactions after liver, bone marrow, and heart transplantation. Transplant Proc 1993; 25: 3337.
10. Qian S, Demetris AJ, Murase N, Rao AS, Fung JJ, Starzl TE. Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology 1994; 19: 916.
11. Starzl TE, Demetris AJ, Murase N, Trucco M, Thomson AW, Rao AS: The lost chord: microchimerism and allograft survival. Immunol Today, (in press).
12. Murase N, Starzl TE, Tanabe M, et al. Variable chimerism, graft versus host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown-Norway rats. Transplantation 1995; 60: 158.
13. Starzl TE, Todo S, Fung J, Demetris AJ, Venkataramanan R, Jain A. FK 506 for human liver, kidney and pancreas transplantation. Lancet 1989; 2: 1000.
14. Sanborn WJ, Hay JE, Porayko MK, et al. Cyclosporine withdrawal for nephrotoxicity in liver transplant recipients does not result in sustained improvement in kidney function and causes cellular and ductopenic rejection. Hepatology 1994; 19: 925
15. Schlitt HJ, Hundrieser J, Ringe B, Pichlmayr R. Donor-type microchimerism associated with graft rejection eight years after liver transplantation. N Engl J Med 1994; 330: 646.
16. Anand AC, Hubscher SG, Gunson BK, McMaster P, Neuberger JM. Timing, significance, and prognosis of late acute liver allograft rejection. Transplantation 1995; 60: 1098.
17. Molleston JP, Alevy YG, Sivasai KSR, Mohanakumar T, Howard TK. Evidence that pediatric liver transplant recipients may undergo late rejection episodes in spite of donor-specific microchimerism. Transplantation 1996; 61: 656.
18. Starzl TE, Koep LJ, Halgrimson CG, et al. Fifteen years of clinical liver transplantation. Gastroenterology 1979; 77: 375.
19. Pappo O, Ramos H, Starzl TE, Fung JJ, Demetris AJ. Structural integrity and identification of causes of liver allograft dysfunction occurring more than 5 years after transplantation. Am J Surg Pathol 1995; 19: 192.