Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts

Transplant Immunology

Volumn 4, Issue 1, 1996, Pages 64-67

  Heemann, Uwe ^a   Azuma, Haruhito ^b   Hamar, Peter ^a   Schmid, Christoph ^a   Tilney, Nicholas ^b   Philipp, Thomas ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; IMMUNOHISTOLOGY; KIDNEY ALLOGRAFT REJECTION; LYMPH NODE; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PURINE METABOLISM; RAT; T LYMPHOCYTE;

EID: 0029990776     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(96)80039-6     Document Type: Conference Paper

References (13)

1. Heemann UW, Tullius SG, Azuma H, Kupiec-Weglinsky JW, Tilncy NL. Adhesion molecules and transplantation. Ann Surg 1994; 219: 4-12.
2. Heemann UW, Schmid C, Azuma H, Tilney NL. The role of leuko cyte adhesion molecules in acute transplant rejection. Curr Opin Nephrol Hypertens 1994; 3: 359-64.
3. Morris RE, Wang J, Blum JR et al. Immunosuppressive effects of the morpholinocthyl ester of MMF (RS-61443) in rat and nonhuman primate recipients of heart allografts. Transplant Proc 1991; 23: (suppl 2): 19-25.
4. European Mycophenolate Mofetil Cooperative Study Group. Placebo-controlled study of mycophenolat mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 1995; 3345: 1231-25.
5. Franklin TJ, Cook JM. The inhibition of nucleic acid synthesis by MMF. Biochem J 1969; 113: 515.
6. Young CJ, Sollinger-IIW. RS-61443: a new immunosuppressive agent. Transplant Proc 1994; 26: 3144-46.
7. Allison AC, Eugui EM, Preferential suppression of lymphocyte proliferation by MMF and predicted long-term effects of mycophenolate motetil in transplantation. Transplant Proc 1994; 26: 3205-10.
8. Allison AC, Kowalski WJ, Muller CJ, Waters RV, Eugui EM, MMF and brequinar, inhibitors of purine and pyrimidine synthesis, block the glycolysation of adhesion molecules. Transplant Proc 1993; 25(suppl 3): 67-70.
9. Hecmann UW, Tullius SG, Tamatami T, Miyasaka M, Milford E, Tilney NL. Infiltration patterns of macrophages and lymphocytes in chronically rejecting rat kidney allografts. Transplant Int 1994; 7: 349-55.
10. Azuma H, Binder J, Heeman U, Schmid C, Tullius SG, Tilney NL. Effects of MMF on functional and morphological changes in chronically rejecting rat kidney allografts. Transplantation 1995; 27: 460-66.
11. Azuma H, Binder J, Hecmann U, Tullius SG, Tilney NL. Effect of MMF on chronic rejection of rat kidney allografts. Transplant Proc 1995; 27: 436-37.
12. Hullett DA, Kawamura T, Fujino Y, Allison AM, Sollinger HW. Prolongation of allograft and xenograft survival with mycophenolate mofetil (RS-61443) and brequinar sodium (DUP-785). Transplant Proc 1993; 25(Part 1): 700-701.
13. Gregory CR, Huang X, Pratt RE. et al. Treatment with rapamycin and MMF reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. Transplantation 1995; 59: 655-61.