Regulation of CD93 cell surface expression by protein kinase C isoenzymes

Microbiology and Immunology

Volumn 50, Issue 2, 2006, Pages 93-103

  Ikewaki, Nobunao ^a   Kulski, Jerzy K ^b   Inoko, Hidetoshi ^b  

^a KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b TOKAI UNIVERSITY   (Japan)

Author keywords

CD93 expression; Down regulation; Protein kinase C isoenzymes (PKCs)

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; COMPLEMENT COMPONENT C1Q RECEPTOR; COMPLEMENT RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GAMMA INTERFERON; GLUTARALDEHYDE; HERBIMYCIN A; INTERLEUKIN 8; ISOENZYME; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MNI 11; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT INTERLEUKIN 2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; ROTTLERIN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL STRAIN; CELL STRAIN U937; CELL SURFACE; CYTOKINE PRODUCTION; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; PHOSPHORYLATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; UMBILICAL VEIN; UPREGULATION;

EID: 33244479639     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2006.tb03774.x     Document Type: Article

References (43)

1. Bohlson, S.S., Silva, R., Fonseca, M.I., and Tenner, A.J. 2005. CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J. Immunol. 175: 1239-1247.
2. Bohlson, S.S., Zhang, M., Ortiz, C.E., and Tenner, A.J. 2005. CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. J. Leukoc. Biol. 77: 80-89.
3. Cho, J.Y., Skubitz, K.M., Katz, D.R., and Chain, B.M. 2003. CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases. Exp. Cell Res. 286: 1-11.
4. Cipriani, B., Knowles, H., Chen, L., Battistini, L., and Brosnan, C.F. 1996. Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. J. Immunol. 157: 3850-3859.
5. Danet, G.H., Luongo, J.L., Butler, G., Lu, M.M., Tenner, A.J., Simon, M.C., and Bonnet, D.A. 2002. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc. Natl. Acad. Sci. U.S.A. 99: 10441-10445.
6. Dean, Y.D., McGreal, E.P., Akatsu, H., and Gasque, P. 2000. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. J. Biol. Chem. 275: 34382-34392.
7. Dean, Y.D., McGreal, E.P., and Gasque, P. 2001. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. Eur. J. Immunol. 31: 1370-1381.
8. Deszo, E.L., Brake, D.K., Cengel, K.A., Kelley, K.W., and Freund, G.G. 2001. CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta. J. Biol. Chem. 276: 10212-10217.
9. Fonseca, M.I., Carpenter, P.M., Park, M., Palmarini, G., Nelson, E.L., and Tenner, A.J. 2001. C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue. J. Leukoc. Biol. 70: 793-800.
10. Gasque, P. 2004. Complement: a unique innate immune sensor for danger signals. Mol. Immunol. 41: 1089-1098.
11. Ghebrehiwet, B., and Peerschke, E.I. 2004. cC1q-R (calreticulin) and gC1q-R/p33: ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection. Mol. Immunol. 41: 173-183.
12. Hendey, B., Zhu, C.L., and Greenstein, S. 2002. Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells. J. Leukoc. Biol. 71: 863-870.
13. Ikewaki, N., and Inoko, H. 1996. Development and characterization of a novel monoclonal antibody (mNI-11) that induces cell adhesion of the LPS-stimulated human monocyte-like cell line U937. J. Leukoc. Biol. 59: 697-708.
14. Ikewaki, N., Tamauchi, H., Yamada, A., Mori, N., Yamao, H., Inoue, H., and Inoko, H. 2000. A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells. J. Clin. Immunol. 20: 317-324.
15. Ikewaki, N., Yamada, A., and Inoko, H. 2003. Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line. Microbiol. Immunol. 47: 775-783.
16. Jack, R.M., Lowenstein, B.A., and Nicholson-Weller, A. 1994. Regulation of C1q receptor expression on human polymorphonuclear leukocytes. J. Immunol. 153: 262-269.
17. Kontny, E., Kurowska, M., Szczepanska, K., and Maslinski, W. 2000. Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. J. Leukoc. Biol. 67: 249-258.
18. Kozawa, O., Suzuki, A., Tokuda, H., Kaida, T., and Uematsu, T. 1997. Protein kinase C activation by interleukin (IL)-1 limits IL-1-induced IL-6 synthesis in osteoblast-like cells: involvement of phosphatidylcholine-specific phospholipase C. J. Cell Biochem. 67: 103-111.
19. Malhotra, R., Willis, A.C., Jensenius, J.C., Jackson, J., and Sim, R.B. 1993. Structure and homology of human C1q receptor (collectin receptor). Immunology 78: 341-348.
20. Maruyama, H., Galvan, M., Waffarn, F., and Tenner, A.J. 2003. Human cord blood leukocyte innate immune responses to defense collagens. Pediatr. Res. 54: 724-731.
21. McGreal, E.P., and Gasque, P. 2002. Structure-function studies of the receptors for complement C1q. Biochem. Soc. Trans. 30: 1010-1014.
22. McGreal, E.P., Ikewaki, N., Akatsu, H., Morgan, B.P., and Gasque, P. 2002. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J. Immunol. 168: 5222-5232.
23. Nauta, A.J., Castellano, G., Xu, W., Woltman, A.M., Borrias, M.C., Daha, M.R., van Kooten, C., and Roos, A. 2004. Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells. J. Immunol. 173: 3044-3050.
24. Nepomuceno, R.R., Henschen-Edman, A.H., Burgess, W.H., and Tenner, A.J. 1997. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity 6: 119-129.
25. Nepomuceno, R.R., Ruiz, S., Park, M., and Tenner, A.J. 1999. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. J. Immunol. 162: 3583-3589.
26. Nepomuceno, R.R., and Tenner, A.J. 1998. C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. J. Immunol. 160: 1929-1935.
27. Ni, H., Ergin, M., Tibudan, S.S., Denning, M.F., Izban, K.F., and Alkan, S. 2003. Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. Br. J. Haematol. 121: 849-856.
28. Nicholson-Weiler, A., and Klickstein, L.B. 1999. C1q-binding proteins and C1q receptors. Curr. Opin. Immunol. 11: 42-46.
29. Norsworthy, P.J., Fossati-Jimack, L., Cortes-Hernandez, J., Taylor, P.R., Bygrave, A.E., Thompson, R.D., Nourshargh, S., Walport, M.J., and Botto, M. 2004. Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J. Immunol. 172: 3406-3414.
30. Norsworthy, P.J., Taylor, P.R., Walport, M.J., and Botto, M. 1999. Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p). Mamm. Genome 10: 789-793.
31. Park, M., and Tenner, A.J. 2003. Cell surface expression of C1qRP/CD93 is stabilized by O-glycosylation. J. Cell Physiol. 196: 512-522.
32. Poole, A.W., Pula, G., Hers, I., Crosby, D., and Jones, M.L. 2004. PKC-interacting proteins: from function to pharmacology. Trends Pharmacol. Sci. 25: 528-535.
33. Pshenichkin, S.P., Szekely, A.M., and Wise, B.C. 1994. Transcriptional and posttranscriptional mechanisms involved in the interleukin-1, steroid, and protein kinase C regulation of nerve growth factor in cortical astrocytes. J. Neurochem. 63: 419-428.
34. Schutze, S., Machleidt, T., and Kronke, M. 1994. The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction. J. Leukoc. Biol. 56: 533-541.
35. Spitaler, M., and Cantrell, D.A. 2004. Protein kinase C and beyond. Nat. Immunol. 5: 785-790.
36. Steinberger, P., Szekeres, A., Wille, S., Stockl, J., Selenko, N., Prager, E., Staffler, G., Madic, O., Stockinger, H., and Knapp, W. 2002. Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. J. Leukoc. Biol. 71: 133-140.
37. Susarla, B.T., and Robinson, M.B. 2003. Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. J. Neurochem. 86: 635-645.
38. Tenner, A.J. 1998. C1q receptors regulating specific functions of phagocytic cells. Immunobiology 199: 250-264.
39. Tenner, A.J., Robinson, S.L., and Ezekowitz, R.A. 1995. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor. Immunity 3: 485-493.
40. Thabard, W., Collette, M., Bataille, R., and Amiot, M. 2001. Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells. Biochem. J. 358: 193-200.
41. Tillman, D.M., Izeradjene, K., Szucs, K.S., Douglas, L., and Houghton, J.A. 2003. Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. Cancer Res. 63: 5118-5125.
42. Walport, M.J., Davies, K.A., and Bott, M. 1998. C1q and systemic lupus erythematosus. Immunobiology 199: 265-285.
43. Webster, S.D., Park, M., Fonseca, M.I., and Tenner, A.J. 2000. Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis. J. Leukoc. Biol. 67: 109-116.