Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning

Journal of Leukocyte Biology

Volumn 71, Issue 1, 2002, Pages 133-140

  Steinberger, Peter ^a   Szekeres, Andreas ^b   Wille, Stefan ^a   Stöckl, Johannes ^a   Selenko, Nicole ^a   Prager, Elisabeth ^b   Staffler, Günther ^b   Madic, Otto ^a   Stockinger, Hannes ^a   Knapp, Walter ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cells surface molecules; Complement; Dendritic cells; Molecular biology

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENTARY DNA; GENE PRODUCT; PROTEIN C1QRP; PROTEIN CD93; SIALOGLYCOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DNA SEQUENCE; GENE EXPRESSION; HEMATOPOIETIC SYSTEM; MOLECULAR CLONING; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; RETROVIRUS; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD44; BASE SEQUENCE; CARRIER PROTEINS; CLONING, MOLECULAR; DENDRITIC CELLS; DNA, COMPLEMENTARY; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PHAGOCYTES; PHAGOCYTOSIS; RECEPTORS, COMPLEMENT; SIALOGLYCOPROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0036142838     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Diagnostic value of monoclonal antibodies to leucocyte-differentiation antigens in lymphoid and nonlymphoid leukemias
2. Joint report of the first international workshop on human leucocyte differentiation antigens by the investigators of the participating laboratories
3. Leucocyte differentiation antigen database
4. CD93 (group 11) cluster workshop report
5. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro
6. Human pulmonary surfactant protein (SP-A), a protein structurally homologous to C1q, can enhance FcR- and CR1-mediated phagocytosis
7. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor
8. Phagocytic cell molecules that bind the collagen-like region of C1q. Involvement in the C1q-mediated enhancement of phagocytosis
9. Dendritic cells and the control of immunity
10. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
11. The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells
12. Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease
13. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells
14. Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes
15. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
16. Signaling and induction of enhanced cytoadhesiveness via the hematopoietic progenitor cell surface molecule CD34
17. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity
18. C1q-binding proteins and C1q receptors
19. The molecular characterization of the fetal stem cell marker AA4
20. Complement receptor type 1 (CR1, CD35) is a receptor for C1q
21. C1Q receptors on cultured human gingival fibroblasts: Analysis of binding properties
22. Identification of types of cells in human peripheral blood that bind C1q
23. Analysis of receptor-mediated C1q binding to human peripheral blood mononuclear cells
24. Characterization and molecular cloning of rat C1qRp, a receptor on NK cells
25. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin
26. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
27. Bacterial lipopolysaccharide, TNF-alpha, and calcium ionophore under serum-free conditions promote rapid dendritic cell-like differentiation in CD14+ monocytes through distinct pathways that activate NK-kappaB
28. The endocytic activity of dendritic cells
29. Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines
30. Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis
31. Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p)
32. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
33. Molecular characterization of the human macrophage mannose receptor: Demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells
34. The mannose receptor is a pattern recognition receptor involved in host defense
35. Innate immune recognition: Mechanisms and pathways
36. Characterization of the murine homolog of C1qR(P): Identical cellular expression pattern, chromosomal location and functional activity of the human and murine C1qR(P)
37. Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis
38. Association of protein kinases with the myeloid cell antigens
39. Phagocytosis of antigens by Langerhans cells in vitro