Protein kinase C δ and η isoenzymes control the shedding of the interleukin 6 receptor α in myeloma cells

Biochemical Journal

Volumn 358, Issue 1, 2001, Pages 193-200

  Thabard, W ^a   Collette, M ^a   Bataille, R ^a   Amiot, M ^a  

^a INSTITUT DE BIOLOGIE   (France)

Author keywords

ERK MAP kinase; Metalloproteinase; Phorbol ester; PKC inhibitors

Indexed keywords

BONE; CELLS; PROTEINS; TUMORS;

DELETERIOUS EFFECTS;

BIOCHEMISTRY;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C DELTA; PROTEIN KINASE C ETA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C ISOENZYME; RAS PROTEIN; ROTTLERIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

ACETOPHENONES; ANTIBODIES, MONOCLONAL; BENZOPYRANS; BLOTTING, WESTERN; CALCIUM; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; ISOENZYMES; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, FLUORESCENCE; MULTIPLE MYELOMA; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; PROTEIN TRANSPORT; RECEPTORS, INTERLEUKIN-6; SUBCELLULAR FRACTIONS; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0035881511     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3580193     Document Type: Article

References (51)

1. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
2. Paracrine rather than autocrine regulation of myeloma cell growth and differentiation by interleukin-6
3. Interleukin-6 family of cytokines and gp130
4. Interleukin-6 and soluble interleukin-6 receptor: Direct stimulation of gp130 and hematopoiesis
5. Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy
6. Myeloma cells release soluble interleukin-6Rα in relation to disease progression by two distinct mechanisms: Alternative splicing and proteolytic cleavage
7. The function of the soluble interleukin 6 (IL-6) receptor in vivo: Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
8. Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)6/soluble IL-6 receptor double-transgenic mice
9. Major role of the soluble interleukin-6/interleukin-6 receptor complex for the proliferation of interleukin-6-dependent human myeloma cell lines
10. Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors
11. Soluble IL-6Rα upregulates IL-6, MMP-1 and MMP-2 secretion in bone marrow stromal cells
12. 2+ mobilization while basal release is predominantly the product of differential mRNA splicing in THP-1 cells
13. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors
14. Metalloprotease-disintegrins: Links to cell adhesion and cleavage of TNFα and Notch
15. Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
16. Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor
17. Signaling through protein kinase C
18. The extended protein kinase C superfamily
19. Pervanadate activation of intracellular kinases leads to tyrosine phosphorylation and shedding of syndecan-1
20. The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading
21. Ectodomain shedding of TGF-α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
22. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C ζ
23. Protein kinase C δ activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
24. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
25. Protein kinase C δ mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells
26. Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma
27. Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle
28. Membrane protein secretases
29. A cellular striptease act
30. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
31. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
32. Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence
33. Protein kinase C δ
34. Protein kinase C isoenzymes: Divergence in signal transduction?
35. Rottlerin, a novel protein kinase inhibitor
36. Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: Reconstitution of the signalling pathway in vitro
37. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
38. Expression of protein kinase C genes in hemopoietic cells is cell-type and B cell-differentiation stage specific
39. Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells
40. Expression of four protein kinase C isoforms in rat fibroblast. Differential alterations in ras-, src-, and fos-transformed cells
41. Different translocation of three distinct PKC isoforms with tumor-promoting phorbol ester in human platelets
42. Constitutive activity of membrane-inserted protein kinase C
43. η gene product is localized in the cell nucleus
44. Selective up-regulation of protein kinase C θ in phorbol ester-sensitive versus -resistant EL4 mouse thymoma cells
45. Phorbol 12-myristate-13-acetate induces protein kinase C η-specific proliferative response in astrocytic tumor cells
46. A metalloproteinase-disintegrin, MDC9/meltrin-γ/ADAM9 and PKC-δ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
47. Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells
48. Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways by a TIMP-3-sensitive metalloproteinase
49. A combination of anti-interleukin 6 murine monoclonal antibody with dexamethasone and high-dose melphalan induces high complete response rates in advanced multiple myeloma
50. The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha comptex in the pathogenesis of multiple myeloma
51. The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients