Physicochemical determinants for drug induced blockade of HERG potassium channels: effect of charge and charge shielding.

Current medicinal chemistry. Cardiovascular and hematological agents

Volumn 1, Issue 3, 2003, Pages 225-241

  Zolotoy, Alexander B ^a   Plouvier, Bertrand P ^a   Beatch, Gregory B ^a   Hayes, Eric S ^a   Wall, Richard A ^a   Walker, Michael J A ^a  

^a 3650 Wesbrook Mall   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; ANTIARRHYTHMIC AGENT; CATION TRANSPORT PROTEIN; KCNH6 PROTEIN, HUMAN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; HEART; HEART ARRHYTHMIA; HUMAN; IC 50; METABOLISM; MORTALITY; PHYSICAL CHEMISTRY; PHYSIOLOGY; REVIEW; TORSADE DES POINTES;

AMINES; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CATION TRANSPORT PROTEINS; CHEMISTRY, PHYSICAL; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; TORSADES DE POINTES;

EID: 4644299288     PISSN: 15680169     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568016033477432     Document Type: Review

References (88)