Glucocorticoid receptor alpha and beta isoforms are not mutated in bipolar affective disorder

Molecular Psychiatry

Volumn 5, Issue 2, 2000, Pages 196-202

  Moutsatsou, P ^a   Tsolakidou, A ^a   Trikkas, G ^b   Troungos, C ^a   Sekeris, C E ^a,c  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^c INSTITUTE OF BIOLOGY   (Greece)

Author keywords

Affective disease; Glucocorticoids; Mutation; Receptor; Receptor isoforms

Indexed keywords

GLUCOCORTICOID RECEPTOR; ISOPROTEIN;

ADULT; AGAR GEL ELECTROPHORESIS; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC PREDISPOSITION; HUMAN; MALE; MANIC DEPRESSIVE PSYCHOSIS; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

EID: 0034097593     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000646     Document Type: Article

References (35)

1. 1 Detera-Wadleigh SD, Badner JA, Goldin LR, Berrettini WH, Sanders AR, Rollins DY et al. Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder on 21q. Am J Hum Genet 1996; 58: 1279-1285.
2. 2 Nothen MM, Cochon N, Craddock N, Albus M, Maier W, Lichtermann D et al. Linkage studies of bipolar disorder to chromosome 18 markers. Biol Psychiatry 1996; 39: 501-508.
3. 3 MacKinnon DF, Jamison KR, DePaulo JR. Genetics of manic depressive illness. Annu Rev Neurosci 1997; 20: 355-373.
4. 4 Musselman DL, Nemeroff CB. Adrenal function in major depression. The Endocrinologist 1995; 5: 91-96.
5. 5 Van Praag HM. Faulty cortisol/serotonin interplay. Psychopathological and biological characterisation of a new, hypothetical depression subtype (SeCA depression). Psychiatr Res 1996; 65: 143-157.
6. 6 Mann JJ, Malone KM. Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry 1997; 41: 162-171.
7. 7 Deuschle M, Schweiger U, Weber B, Gotthardt U, Korner A, Schmider J et al. Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls. J Clin Endocrinol Metab 1997; 82: 234-238.
8. 8 Lowy MT, Reder AT, Antel JP, Meltzer HY. Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone. Am J Psychiatry 1984; 141: 1365-1370.
9. 9 Young EA, Haskett RF, Weinberg VM, Watson SJ, Akie H. Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry 1991; 48: 693-699.
10. 10 Barden N, Reul JMH, Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 1995; 18: 6-11.
11. 11 Murphy BEP. Antiglucocorticoid therapies in major depression: a review. Psychoneuroendocrinology 1997; 22: 5125-5132.
12. 12 Pariante CM, Nemeroff CB, Miller AH. Glucocorticoid receptors in depression. Israel Med Sci 1995; 31: 705-712.
13. 13 Schlechte JA, Sherman B. Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolaemia. Psychoneuroendocrinology 1985; 10: 469-474.
14. 14 Wassef A, Smith EM, Rose RM, Gardner R, Nguyen H, Meyer WJ. Mononuclear leucocyte glucocorticoid receptor binding characteristics and down regulation in major depression. Psychoneuroendocrinology 1990; 15: 59-68.
15. 15 Gormley GJ, Lowy MT, Reder AT, Hospelhom VD, Antel JP, Meltzer HY. Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test. Am J Psychiatry 1985; 142: 1278-1284.
16. 16 Whalley CJ, Borthwick N, Copolov D, Dick H, Christie JE, Fink G. Glucocorticoid receptors and depression. Br Med J 1986; 292: 859-861.
17. 17 Rupprecht R, Kornhuber J, Wodarz N, Lugauer J, Göbel C, Riederer P et al. Lymphocyte glucocorticoid receptor binding during depression and after clinical recovery. J Affect Dis 1991; 22: 31-35.
18. 18 Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 1985; 318: 635-641.
19. 19 Encio IJ, Detera-Wadleigh SD. The genomic structure of the human glucocorticoid receptor. J Biol Chem 1991; 266: 7182-7188.
20. 20 Nobukumi Y, Smith CL, Hager GL, Detera-Wadleigh SD. Characterization of the human glucocorticoid receptor promoter. Biochemistry 1995; 34: 8207-82014.
21. 21 Tsai MJ, O'Malley BW. Molecular mechanisms of action of steroid/thyroid receptor super-family members. Ann Rev Biochem 1994; 63: 451-486.
22. 22 Beato M, Herrlich P, Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell 1995; 83: 851-857.
23. 23 Gottlicher M, Heck S, Herrlich P. Transcriptional cross-talk, the second mode of steroid hormone receptor action. J Mol Med 1998; 76: 480-489.
24. 24 Krstic MD, Rogatsky I, Yamamoto KR, Garabedian MJ. Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. Mol Cell Biol 1997; 17: 3947-3954.
25. 25 Rogatsky I, Logan SK, Garabedian MJ. Antagonism of glucocorticoid receptor transcriptional activation by the c-fun N-terminal kinase. Proc Natl Acad Sci USA 1998; 95: 2050-2055.
26. 26 Hurley DM, Accili D, Stratakis CA, Karl M, Vamvakopoulos N, Rorer E et al. Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familiar glucocorticoid resistance. J Clin Invest 1991; 87: 680-686.
27. 27 Chrousos GP, Castro M, Leung DYM, Webster E, Kino T, Bamberger C et al. Molecular mechanisms of glucocorticoid resistance/ hypersensitivity potential clinical implications. Am J Respir Crit Care Med 1996; 154: 539-544.
28. 28 Rogatsky I, Waase CLM, Carabedian MJ. Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). J Biol Chem 1998; 273: 14315-14321.
29. 29 Bamberger CM, Bamberger A, DeCastro M, Chrousos GP. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995; 95: 2435-2441.
30. 30 Koper JW, Stolk RP, De Lange P, Huizenga NATM, Molijn GJ, Pols HAP et al. Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. Hum Genet 1997; 99: 663-668.
31. 31 Karl M, Lamberts SWJ, Detera-Wadleigh SD, Encio IJ, Stratakis CA, Hurley DM et al. Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene. J Clin Endocrinol Metab 1993; 76: 683-689.
32. 32 Shimizu S, Nomura K, Ujihara M, Sakamoto K, Shibata H, Suzuki T et al. An allele-specific abnormal transcript of the heat shock protein 70 gene in patients with major depression. Biochem Biophys Res Commun 1996; 219: 745-752.
33. 33 Adcock IM. Steroid resistance in asthma: molecular mechanisms. Am J Respir Crit Care Med 1996; 154: 558-561.
34. 34 Webster JC, Jewell CM, Bodwell JE, Munck A, Sar M, Cidlowski JA. Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein. J Biol Chem 1997; 272: 9287-9293.
35. 35 Nuller JL, Ostroumova MN. Resistance to inhibiting effect of dexamethasone in patients with endogenous depression. Acta Psychiatr Scand 1980; 61: 169-177.