Embryonic stem cells in predictive cardiotoxicity: Laser capture microscopy enables assay development

Toxicological Sciences

Volumn 90, Issue 1, 2006, Pages 149-158

  Chaudhary, Khuram W ^a,b   Barrezueta, Nestor X ^a   Bauchmann, Mary B ^a   Milici, Anthony J ^a   Beckius, Gretchen ^a   Stedman, Donald B ^a   Hambor, John E ^a   Blake, William L ^a   McNeish, John D ^a   Bahinski, Anthony ^a   Cezar, Gabriela Gebrin ^a,b,c  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

Cardiomyocytes; Cardiotoxicity; Embryonic stem cells; Laser microdissection and pressure catapulting

Indexed keywords

ALPHA ACTIN; BIOLOGICAL MARKER; CALCIUM CHANNEL L TYPE; CONNEXIN 43; CONNEXIN 45; NIFEDIPINE; PHOSPHOLAMBAN; TRANSCRIPTION FACTOR GATA 4;

ANIMAL CELL; ARTICLE; CARDIOTOXICITY; CELL ASSAY; CELL HETEROGENEITY; CELL TYPE; CONTROLLED STUDY; EMBRYONIC STEM CELL; EXTRACELLULAR CALCIUM; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LASER CAPTURE MICRODISSECTION; LASER PRESSURE CATAPULTING; MOUSE; NONHUMAN; PREDICTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VALIDATION PROCESS;

ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL MARKERS; CALCIUM; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FETAL HEART; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART DISEASES; LASERS; MICE; MICE, INBRED DBA; MICRODISSECTION; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC; NIFEDIPINE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STEM CELLS; XENOBIOTICS;

ANIMALIA;

EID: 33144474711     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfj078     Document Type: Article

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