Toxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells

Biosensors and Bioelectronics

Volumn 21, Issue 9, 2006, Pages 1804-1811

  Mohan, Dinesh K ^b   Molnar, Peter ^a,b,c   Hickman, James J ^a,b,c  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b AMRL   (United States)

^c Department of Bioengineering ^*  (United States)

Author keywords

Action potential shape analysis; Computer simulation; Hodgkin Huxley model; Linear thermodynamic model; NG108 15; Toxin detection

Indexed keywords

COMPUTER SIMULATION; ELECTRIC CURRENTS; ELECTROPHYSIOLOGY; MATHEMATICAL MODELS; RATE CONSTANTS; THERMODYNAMICS; TOXIC MATERIALS;

ACTION POTENTIAL SHAPE ANALYSIS; HODGKIN-HUXLEY MODEL; LINEAR THERMODYNAMIC MODEL; NG108-15; TOXIN DETECTION;

CELLS;

CALCIUM; ION CHANNEL; POTASSIUM; PYRETHROID; SODIUM; SODIUM CHANNEL BLOCKING AGENT; TEFLUTHRIN; TETRODOTOXIN; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL LINE; DRUG MECHANISM; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; MATHEMATICAL MODEL; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; RAT; RECORDING; THERMODYNAMICS;

ACTION POTENTIALS; BIOLOGICAL ASSAY; CELL DIFFERENTIATION; CELL LINE; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; MICE; MODELS, NEUROLOGICAL; NEURONS; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; RATS;

ANIMALIA;

EID: 32944477947     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bios.2005.09.008     Document Type: Article

References (55)

1. D. Agin Excitability phenomena in membranes R. Rosen Foundations of Mathematical Biology 1972 Academic Press New York 253 277
2. I.A. Ahmed, and P.M. Hopkins Caffeine and ryanodine differentially modify a calcium-dependent component of soma action-potentials in identified molluscan (Lymnaea stagnalis) neurons in-situ Comp. Biochem. Physiol. C: Pharmacol. Toxicol. Endocrinol. 105 3 1993 363 372
3. M. Akay, and E. Mazza Non-linear dynamic analysis of hypoxia-induced changes in action potential shape in neurons cultured from the rostral ventrolateral medulla (RVLM) FASEB J. 12 4 1998 2881
4. J.M. Amigo, and J. Szczepanski On the number of states of the neuronal sources Biosystems 68 1 2003 57 66
5. A.J. Baeumner Biosensors for environmental pollutants and food contaminants Anal. Bioanal. Chem. 377 3 2003 434 445
6. A. Bentleya, and A. Atkinsona Whole cell biosensors - electrochemical and optical approaches to ecotoxicity testing Toxicol. In Vitro 15 2001 469 475
7. L. Bousse Whole cell biosensors Sens. Actuators B: Chem. 34 1-3 1996 270 275
8. M. Chiappalone, and A. Vato Networks of neurons coupled to microelectrode arrays: a neuronal sensory system for pharmacological applications Biosens. Bioelectron. 18 2003 627 634
9. R.B. Clark, and R.A. Bouchard Heterogeneity of action-potential wave-forms and potassium currents in rat ventricle Cardiovasc. Res. 27 10 1993 1795 1799
10. Cohen, H., 1976. Mathematical developments in Hodgkin-Huxley theory and its approximations. In: Levin, S.A. (Ed.), Proceedings of the Ninth Symposium on Mathematical Biology held in New York, January 1975. American Mathematical Society, Washington, pp. 89-124.
11. G.E. Croston Functional cell-based uHTS in chemical genomic drug discovery Trends Biotechnol. 20 3 2002 110 115
12. M.C.T. Denyer, and M. Riehle Preliminary study on the suitability of a pharmacological bio-assay based on cardiac myocytes cultured over microfabricated microelectrode arrays Med. Biol. Eng. Comput. 36 5 1998 638 644
13. A. Destexhe, and J.R. Huguenard Nonlinear thermodynamic models of voltage-dependent currents J. Comput. Neurosci. 9 2000 259 270
14. L. Djouhri, and S.N. Lawson Changes in somatic action potential shape in guinea-pig nociceptive primary afferent neurones during inflammation in vivo J. Physiol.: Lond. 520 2 1999 565 576
15. J.A. Doebler Effects of neutral ionophores on membrane electrical characteristics of NG108-15 cells Toxicol. Lett. 114 1-3 2000 27 38
16. S. Dokos, and B. Celler Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model J. Theor. Biol. 181 3 1996 245 272
17. G.P. Evans, and M.G. Briers Can biosensors help to protect drinking-water Biosensors 2 5 1986 287 300
18. G.W. Gross, and A. Harsch Odor, drug and toxin analysis with neuronal networks in vitro: extracellular array recording of network responses Biosens. Bioelectron. 12 5 1997 373 393
19. G.W. Gross, and B.K. Rhoades the use of neuronal networks on multielectrode arrays as biosensors Biosen. Bioelectron. 10 6-7 1995 553 567
20. D.E. Heck, and A. Roy Nucleic acid microarray technology for toxicology: promise and practicalities Biological Reactive Intermediates Vi 500 2001 709 714
21. H. Higashida, and R.A. Streaty Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a 2nd messenger in Ng108-15 neuroblastoma glioma hybrid-cells Proc. Natl. Acad. Sci. U.S.A. 83 4 1986 942 946
22. L.A. Hodgkin, and F.A. Huxley A quantitative description of membrane current and its application to conduction and excitation in nerve J. Physiol. 117 1952 500 544
23. Q. Hu, and F. Huang Inhibition of Toosendanin on the delayed rectifier potassium current in neuroblastoma X glioma NG108-15 cells. Brain Res. 751 1997 47 53
24. D.K. Jorkasky What does the clinician want to know from the toxicologist? Toxicol. Lett. 102-103 1998 539 543
25. D.R. Jung, and D.S. Cuttino Cell-based sensor microelectrode array characterized by imaging x-ray photoelectron spectroscopy, scanning electron microscopy, impedance measurements, and extracellular recordings J. Vac. Sci. Technol. A: Vac. Surf. Films 16 3 1998 1183 1188
26. L.B. Kinter, and J.P. Valentin Safety pharmacology and risk assessment Fundam. Clin. Pharmacol. 16 3 2002 175 182
27. M. Krause, and S. Ingebrandt Extended gate electrode arrays for extracellular signal recordings Sens. Actuators B 70 2000 101 107
28. E.A. Lukyanetz Diversity and properties of calcium channel types in NG108-15 hybrid cells Neuroscience 87 1 1998 265 274
29. W. Ma, and G.M. Grant Kir 4.1 channel expression in neuroblastoma× glioma hybrid NG108-15 cell line Dev. Brain Res. 114 1 1999 127 134
30. W. Ma, and J.J. Pancrazio Neuronal and glial epitopes and transmitter-synthesizing enzymes appear in parallel with membrane excitability during neuroblastoma X glioma hybrid differentiation Dev. Brain Res. 106 1998 155 163
31. M. Martin-Caraballo, and J.J. Greer Development of potassium conductances in perinatal rat phrenic motoneurons J. Neurophysiol. 83 6 2000 3497 3508
32. T.W. Mason Fluorescent and Luminescent Probes for Biological Activity 1993 Academic Press London
33. S.I. Morefield, and E.W. Keefer Drug evaluations using neuronal networks cultured on microelectrode arrays Biosens. Bioelectron. 15 7-8 2000 383 396
34. K. Muraki, and Y. Imaizumi Effects of noradrenaline on membrane currents and action-potential shape in smooth-muscle cells from guinea-pig ureter J. Physiol. Lond. 481 3 1994 617 627
35. M. Naessens, and A. Tran-Minh Whole-cell biosensor for determination of volatile organic compounds in the form of aerosols Anal. Chim. Acta 364 1-3 1998 153 158
36. M. Naessens, and C. Tran-Minh Whole-cell biosensor for direct determination of solvent vapours Biosens. Bioelectron. 13 3-4 1998 341 346
37. + currents in repolarization Circ. Res. 82 1 1998 63 81
38. A. Offenhausser, and W. Knoll Cell-transistor hybrid systems and their potential applications Trends Biotechnol. 19 2 2001 62 66
39. E.H. Ohlstein, and R.R. Ruffolo Drug discovery in the next millennium Ann. Rev. Pharmacol. Toxicol. 40 2000 177 191
40. E. Otten, and M. Hulliger A model study on the influence of a slowly activating potassium conductance on repetitive firing patterns of muscle spindle primary endings J. Theor. Biol. 173 1 1995 67 78
41. B.M. Paddle Biosensors for chemical and biological agents of defence interest Biosens. Bioelectron. 11 11 1996 1079 1113
42. J.C. Philp, and S. Balmand Whole cell immobilised biosensors for toxicity assessment of a wastewater treatment plant treating phenolics-containing waste Anal. Chim. Acta 487 2003 61 74
43. K.R. Rogers Biosensors for environmental applications Biosens. Bioelectron. 10 6-7 1995 533 541
44. E.A. Schaffner, and L.J. Barker Investigation of the factors necessary for growth of hippocampal neurons in a defined system J. Neurosci. Methods 62 1995 111 119
45. H. Schmitt, and H. Meves Model experiments on squid axons and NG108-15 mouse neuroblastoma* rat glioma hybrid cells J. Physiol. (Paris) 89 1995 181 193
46. R.M. Shaw, and Y. Rudy Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration Cardiovasc. Res. 35 2 1997 256 272
47. N.A. Shevtsova, and K. Ptak Computational modeling of bursting pacemaker neurons in the pre-Bötzinger complex Neurocomputing 52-54 2003 933 942
48. C.I. Spencer, and K.H. Yuill Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhytm in isolated mammalian ventricular myocytes and perfused hearts J. Pharmacol. Exp. Ther. 298 2001 1067 1082
49. A. Stett, and U. Egert Biological application of microelectrode arrays in drug discovery and basic research Anal. Bioanal. Chem. 377 3 2003 486 495
50. T. Tojima, and Y. Yamane Acquisition of neuronal proteins during differentiation of NG108-15 cells Neurosci. Res. 37 2000 153 161
51. A. Tzoris, and D. Fearnside Direct toxicity assessment of wastewater: Baroxymeter, a portable rapid toxicity device and the industry perspective Environ. Toxicol. 17 3 2002 284 290
52. P.F. van Soest, and K.S. Kits Conopressin affects excitability, firing, and action potential shape through stimulation of transient and persistent inward currents in mulluscan neurons J. Neurophysiol. 79 4 1998 1619 1632
53. I. Weiss, and A. Urbaszek Simulation of the cardiac action-potentials of various cell-types with account being taken of neural influencing factors Biomed. Tech. 40 3 1995 64 69
54. T.F. Weiss Cellular Biophysics 1996 The MIT Press Cambridge, MA
55. Y. Xia, and K.V. Gopal Differential acute effects of fluoxetine on frontal and auditory cortex networks in vitro Brain Res. 973 2 2003 151 160