-
1
-
-
0032748914
-
Antithrombin agents: The new class of anticoagulant and antithrombotic drugs
-
Fareed J, B. E. Lewis, D. D. Callas, D. A. Hoppensteadt, J. M. Walenga & R. L. Bick: Antithrombin agents: the new class of anticoagulant and antithrombotic drugs. Clin Appl Thromb Hemost 5, S45-55 (1999)
-
(1999)
Clin Appl Thromb Hemost
, vol.5
-
-
Fareed, J.1
Lewis, B.E.2
Callas, D.D.3
Hoppensteadt, D.A.4
Walenga, J.M.5
Bick, R.L.6
-
3
-
-
0030462546
-
New data on the pharmacology of heparin and low molecular weight heparins
-
Samama MM, L. Bara & I. Gouin-Thibault: New data on the pharmacology of heparin and low molecular weight heparins. Drugs 52 Suppl 7, 8-14 (1996)
-
(1996)
Drugs
, vol.52
, Issue.SUPPL. 7
, pp. 8-14
-
-
Samama, M.M.1
Bara, L.2
Gouin-Thibault, I.3
-
4
-
-
0026761832
-
Low molecular weight heparin in prevention of perioperative thrombosis
-
Leizorovicz A, M. C. Haugh, F. R. Chapuis, M.M. Samama & J. P. Boissel: Low molecular weight heparin in prevention of perioperative thrombosis. Br Med J 305, 913-920 (1992)
-
(1992)
Br Med J
, vol.305
, pp. 913-920
-
-
Leizorovicz, A.1
Haugh, M.C.2
Chapuis, F.R.3
Samama, M.M.4
Boissel, J.P.5
-
5
-
-
0029878458
-
Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia
-
Amiral J, M. Wolf, A. Fischer, C. Boyer-Neumann, A. Vissac, & D. Meyer: Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia. Br J Haematol 92, 954-959 (1996)
-
(1996)
Br J Haematol
, vol.92
, pp. 954-959
-
-
Amiral, J.1
Wolf, M.2
Fischer, A.3
Boyer-Neumann, C.4
Vissac, A.5
Meyer, D.6
-
6
-
-
0031768621
-
Heparin-induced thrombocytopenia
-
Ortel TL: Heparin-induced thrombocytopenia. Semin Hematol 35, 1-2 (1998)
-
(1998)
Semin Hematol
, vol.35
, pp. 1-2
-
-
Ortel, T.L.1
-
8
-
-
0026779989
-
Leeches to hirulogs and other thrombin-directed antithrombotics
-
Fenton II JW: Leeches to hirulogs and other thrombin-directed antithrombotics. Hematol Oncol Clin North Am 6, 1121-1129 (1992)
-
(1992)
Hematol Oncol Clin North Am
, vol.6
, pp. 1121-1129
-
-
Fenton II, J.W.1
-
9
-
-
0033378391
-
Strategies and progress towards the ideal orally active thrombin inhibitor
-
Rewinkel JB & A. E. Adang: Strategies and progress towards the ideal orally active thrombin inhibitor. Curr Pharm Des 5, 1043-1075 (1999)
-
(1999)
Curr Pharm des
, vol.5
, pp. 1043-1075
-
-
Rewinkel, J.B.1
Adang, A.E.2
-
10
-
-
14044276225
-
Peptidomimetic thrombin inhibitors
-
Kikelj D: Peptidomimetic thrombin inhibitors. Pathophysiol Haemost Thromb 33, 487-491 (2003/2004)
-
(2003)
Pathophysiol Haemost Thromb
, vol.33
, pp. 487-491
-
-
Kikelj, D.1
-
11
-
-
18544364319
-
Thrombin and thrombosis
-
Fenton II JW, D.V. Brenzniak, F.A. Ofosu, G.X. Shen, J.R. Jacobson, J.G. Garcia: Thrombin and thrombosis. Cur Drug Target: Cardiovasc Haematol Disord 5, 115-120 (2005)
-
(2005)
Cur Drug Target: Cardiovasc Haematol Disord
, vol.5
, pp. 115-120
-
-
Fenton II, J.W.1
Brenzniak, D.V.2
Ofosu, F.A.3
Shen, G.X.4
Jacobson, J.R.5
Garcia, J.G.6
-
12
-
-
0025898662
-
The history of leeching and hirudin
-
Fields WS: The history of leeching and hirudin. Haemostasis 21 Suppl 1, 3-10 (1991)
-
(1991)
Haemostasis
, vol.21
, Issue.SUPPL. 1
, pp. 3-10
-
-
Fields, W.S.1
-
13
-
-
0025899470
-
Hirudin and derivatives as anticoagulant agents
-
Markwardt F: Hirudin and derivatives as anticoagulant agents. Thromb Haemost 66, 141-152 (1991)
-
(1991)
Thromb Haemost
, vol.66
, pp. 141-152
-
-
Markwardt, F.1
-
14
-
-
0023766115
-
Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin
-
Braun PJ, S. Dennis, J. Hofsteenge, & S. R. Stone: Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin. Biochemistry 27, 6517-6522 (1988)
-
(1988)
Biochemistry
, vol.27
, pp. 6517-6522
-
-
Braun, P.J.1
Dennis, S.2
Hofsteenge, J.3
Stone, S.R.4
-
15
-
-
0030722727
-
A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement
-
Eriksson BI, P. Wille-Jorgensen, P. Kalebo, P. Mouret, N. Rosencher, P. Bosch, M. Baur, S. Ekman, D. Bach, S. Lindbratt & P. Close: A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement. N Engl J Med 337, 1329-1335 (1997)
-
(1997)
N Engl J Med
, vol.337
, pp. 1329-1335
-
-
Eriksson, B.I.1
Wille-Jorgensen, P.2
Kalebo, P.3
Mouret, P.4
Rosencher, N.5
Bosch, P.6
Baur, M.7
Ekman, S.8
Bach, D.9
Lindbratt, S.10
Close, P.11
-
16
-
-
0030953595
-
Prevention of thromboembolism with use of recombinant hirudin. Results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement
-
Eriksson BI, S. Ekman, S. Lindbratt, M. Baur, D. Bach, C. Torholm, P. Kalebo & P. Close: Prevention of thromboembolism with use of recombinant hirudin. Results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement. J Bone Joint Surg Am 79, 326-333 (1997)
-
(1997)
J Bone Joint Surg Am
, vol.79
, pp. 326-333
-
-
Eriksson, B.I.1
Ekman, S.2
Lindbratt, S.3
Baur, M.4
Bach, D.5
Torholm, C.6
Kalebo, P.7
Close, P.8
-
17
-
-
0028037517
-
Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
-
The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators
-
Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators. Circulation 90, 1631-1637 (1994)
-
(1994)
Circulation
, vol.90
, pp. 1631-1637
-
-
-
18
-
-
0028092111
-
Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial
-
Antman EM: Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial. Circulation 90, 1624-1630 (1994)
-
(1994)
Circulation
, vol.90
, pp. 1624-1630
-
-
Antman, E.M.1
-
19
-
-
0028117846
-
Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study. A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte (ALKK)
-
Neuhaus KL, R. von Essen, U. Tebbe, A. Jessel, H. Heinrichs, W. Maurer, W. Doring, D. Harmjanz, V. Kotter, E. Kalhammer & et al: Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study. A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte (ALKK) Circulation 90: 1638-1642 (1994)
-
(1994)
Circulation
, vol.90
, pp. 1638-1642
-
-
Neuhaus, K.L.1
Von Essen, R.2
Tebbe, U.3
Jessel, A.4
Heinrichs, H.5
Maurer, W.6
Doring, W.7
Harmjanz, D.8
Kotter, V.9
Kalhammer, E.10
-
20
-
-
0029835392
-
A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
-
The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb investigators
-
A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb investigators. N Engl J Med 335, 775-782 (1996)
-
(1996)
N Engl J Med
, vol.335
, pp. 775-782
-
-
-
21
-
-
0029788104
-
Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial
-
Antman EM: Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial. Circulation 94, 911-921 (1996)
-
(1996)
Circulation
, vol.94
, pp. 911-921
-
-
Antman, E.M.1
-
22
-
-
0029880254
-
Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury
-
Rade JJ, A. H. Schulick, R. Virmani & D.A. Dichek: Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat Med 2, 293-298 (1996)
-
(1996)
Nat Med
, vol.2
, pp. 293-298
-
-
Rade, J.J.1
Schulick, A.H.2
Virmani, R.3
Dichek, D.A.4
-
23
-
-
0029101260
-
A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty
-
Helvetica Investigators
-
Serruys PW, J. P. Herrman, R. Simon, W. Rutsch, C. Bode, G. J. Laarman, R. van Dijk, A. A. van den Bos, V. A. Umans, K. A. Fox & et al: A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty. Helvetica Investigators. N Engl J Med 333, 757-763 (1995)
-
(1995)
N Engl J Med
, vol.333
, pp. 757-763
-
-
Serruys, P.W.1
Herrman, J.P.2
Simon, R.3
Rutsch, W.4
Bode, C.5
Laarman, G.J.6
Van Dijk, R.7
Van Den Bos, A.A.8
Umans, V.A.9
Fox, K.A.10
-
24
-
-
0031912147
-
Prolonged thrombin inhibition reduces restenosis after balloon angioplasty in porcine coronary arteries
-
Gallo R, A. Padurean, V. Toschi, J. Bichler, J.T. Fallon, J. H. Chesebro, V. Fuster & J. J. Badimon: Prolonged thrombin inhibition reduces restenosis after balloon angioplasty in porcine coronary arteries. Circulation 97, 581-588 (1998)
-
(1998)
Circulation
, vol.97
, pp. 581-588
-
-
Gallo, R.1
Padurean, A.2
Toschi, V.3
Bichler, J.4
Fallon, J.T.5
Chesebro, J.H.6
Fuster, V.7
Badimon, J.J.8
-
25
-
-
0025900309
-
Human alpha- and zeta-thrombin inhibition by recombinant HV1 and HV2K47 hirudins
-
Witting JI, D.V. Brezniak, J. R. Hayes & J.W. Fenton II: Human alpha- and zeta-thrombin inhibition by recombinant HV1 and HV2K47 hirudins. Thromb Res 63, 473-479 (1991)
-
(1991)
Thromb Res
, vol.63
, pp. 473-479
-
-
Witting, J.I.1
Brezniak, D.V.2
Hayes, J.R.3
Fenton II, J.W.4
-
26
-
-
0024411549
-
Thrombin anion-binding exosite interactions with heparin and various polyanions
-
Fenton II JW, J. I. Witting, C. Pouliott & J. Fareed: Thrombin anion-binding exosite interactions with heparin and various polyanions. Ann N Y Acad Sci 556, 158-165 (1989)
-
(1989)
Ann N Y Acad Sci
, vol.556
, pp. 158-165
-
-
Fenton II, J.W.1
Witting, J.I.2
Pouliott, C.3
Fareed, J.4
-
27
-
-
0025346345
-
Design and characterization of hirulogs: A novel class of bivalent peptide inhibitors of thrombin
-
Maraganore JM, P. Bourdon, J. Jablonski, K. L. Ramachandran & J. W. Fenton II: Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin. Biochemistry 29, 7095-7101 (1990)
-
(1990)
Biochemistry
, vol.29
, pp. 7095-7101
-
-
Maraganore, J.M.1
Bourdon, P.2
Jablonski, J.3
Ramachandran, K.L.4
Fenton II, J.W.5
-
29
-
-
0027497137
-
Initial experience with a direct antithrombin, Hirulog, in unstable angina. Anticoagulant, antithrombotic, and clinical effects
-
Lidon RM, P. Theroux, M. Juneau, B. Adelman & J. Maraganore: Initial experience with a direct antithrombin, Hirulog, in unstable angina. Anticoagulant, antithrombotic, and clinical effects. Circulation 88, 1495-1501 (1993)
-
(1993)
Circulation
, vol.88
, pp. 1495-1501
-
-
Lidon, R.M.1
Theroux, P.2
Juneau, M.3
Adelman, B.4
Maraganore, J.5
-
30
-
-
0028326748
-
A pilot, early angiographic patency study using a direct thrombin inhibitor as adjunctive therapy to streptokinase in acute myocardial infarction
-
Lidon RM, P. Theroux, J. Lesperance, B. Adelman, R. Bonan, D. Duval & J. Levesque: A pilot, early angiographic patency study using a direct thrombin inhibitor as adjunctive therapy to streptokinase in acute myocardial infarction, Circulation 89, 1567-1572 (1994)
-
(1994)
Circulation
, vol.89
, pp. 1567-1572
-
-
Lidon, R.M.1
Theroux, P.2
Lesperance, J.3
Adelman, B.4
Bonan, R.5
Duval, D.6
Levesque, J.7
-
31
-
-
0031761307
-
A randomized comparison of bivalirudin and heparin in patients undergoing coronary angioplasty for postinfarction angina
-
Hirulog Angioplasty Study Investigators
-
Bittl JA & F. Feit: A randomized comparison of bivalirudin and heparin in patients undergoing coronary angioplasty for postinfarction angina. Hirulog Angioplasty Study Investigators. Am J Cardiol 82, 43P-49P (1998)
-
(1998)
Am J Cardiol
, vol.82
-
-
Bittl, J.A.1
Feit, F.2
-
32
-
-
0032731676
-
Antithrombin agents as adjuncts to thrombolytic therapy
-
French JK & H. D. White: Antithrombin agents as adjuncts to thrombolytic therapy. J Thromb Thrombolysis 8, 159-166 (1999)
-
(1999)
J Thromb Thrombolysis
, vol.8
, pp. 159-166
-
-
French, J.K.1
White, H.D.2
-
33
-
-
0031728681
-
Evolution of improved antithrombotic and antiplatelet agents: Genesis of the Comparison of Abciximab Complications with Hirulog [and back-Up Abciximab] Events Trial (CACHET)
-
Topol EJ: Evolution of improved antithrombotic and antiplatelet agents: genesis of the Comparison of Abciximab Complications with Hirulog [and back-Up Abciximab] Events Trial (CACHET) Am J Cardiol 82, 63P-68P (1998)
-
(1998)
Am J Cardiol
, vol.82
-
-
Topol, E.J.1
-
34
-
-
0028962959
-
Inhibition of platelet deposition by combined hirulog and aspirin in a rat carotid endarterectomy model
-
Hamelink JK, D. B. Tang, C. F. Barr, M. R. Jackson, T. J. Reid, E. R. Gomez & B. M. Alving: Inhibition of platelet deposition by combined hirulog and aspirin in a rat carotid endarterectomy model. J Vasc Surg 21, 492-498 (1995)
-
(1995)
J Vasc Surg
, vol.21
, pp. 492-498
-
-
Hamelink, J.K.1
Tang, D.B.2
Barr, C.F.3
Jackson, M.R.4
Reid, T.J.5
Gomez, E.R.6
Alving, B.M.7
-
35
-
-
0030902163
-
Inhibition by hirulog-1 of generation of plasminogen activator inhibitor-1 from vascular smooth-muscle cells induced by thrombin
-
Ren S, J. W. Fenton II, J. M. Maraganore, A. Angel & G. X. Shen: Inhibition by hirulog-1 of generation of plasminogen activator inhibitor-1 from vascular smooth-muscle cells induced by thrombin, J Cardiovasc Pharmacol 29, 337-342 (1997)
-
(1997)
J Cardiovasc Pharmacol
, vol.29
, pp. 337-342
-
-
Ren, S.1
Fenton II, J.W.2
Maraganore, J.M.3
Angel, A.4
Shen, G.X.5
-
36
-
-
0034037776
-
Hirulog-1 reduces expression of platelet-derived growth factor in neointima of rat carotid artery induced by balloon catheter injury
-
Xue M, J. W. Fenton II & G. X. Shen: Hirulog-1 reduces expression of platelet-derived growth factor in neointima of rat carotid artery induced by balloon catheter injury. J Vasc Res 37, 82-92 (2000)
-
(2000)
J Vasc Res
, vol.37
, pp. 82-92
-
-
Xue, M.1
Fenton II, J.W.2
Shen, G.X.3
-
37
-
-
8944234846
-
Effectiveness of hirulog in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits
-
Sarembock IJ, S. D. Gertz, L. M. Thome, K. W. McCoy, M. Ragosta, E. R. Powers, J. M. Maraganore & L. W. Gimple: Effectiveness of hirulog in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. J Vasc Res 33, 308-314 (1996)
-
(1996)
J Vasc Res
, vol.33
, pp. 308-314
-
-
Sarembock, I.J.1
Gertz, S.D.2
Thome, L.M.3
McCoy, K.W.4
Ragosta, M.5
Powers, E.R.6
Maraganore, J.M.7
Gimple, L.W.8
-
38
-
-
0033842367
-
New bivalent thrombin inhibitors with N(alpha)(methyl)arginine at the P1-position
-
Steinmetzer T, M. Batdordshjin, F. Pineda, L. Seyfarth, A. Vogel, S. Reissmann, J. Hauptmann & J. Sturzebecher: New bivalent thrombin inhibitors with N(alpha)(methyl)arginine at the P1-position. Biol Chem 381, 603-610 (2000)
-
(2000)
Biol Chem
, vol.381
, pp. 603-610
-
-
Steinmetzer, T.1
Batdordshjin, M.2
Pineda, F.3
Seyfarth, L.4
Vogel, A.5
Reissmann, S.6
Hauptmann, J.7
Sturzebecher, J.8
-
39
-
-
0029879577
-
Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-ketc-amide transition-state mimetic
-
Krishnan R, A. Tulinsky, G. P. Vlasuk, D. Pearson, P. Vallar, P., Bergum, T. K. Brunck & W. C. Ripka: Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-ketc-amide transition-state mimetic. Protein Sci 5, 422-433 (1996)
-
(1996)
Protein Sci
, vol.5
, pp. 422-433
-
-
Krishnan, R.1
Tulinsky, A.2
Vlasuk, G.P.3
Pearson, D.4
Vallar, P.5
Bergum, P.6
Brunck, T.K.7
Ripka, W.C.8
-
40
-
-
2642675221
-
Effective use of BCH-2763, a new potent injectable direct thrombin inhibitor, in combination with tissue plasminogen activator (tPA) in a rat arterial thrombolysis model
-
Deschenes I, C. D. Finkle & P. D. Winocour: Effective use of BCH-2763, a new potent injectable direct thrombin inhibitor, in combination with tissue plasminogen activator (tPA) in a rat arterial thrombolysis model. Thromb Haemost 80, 186-191 (1998)
-
(1998)
Thromb Haemost
, vol.80
, pp. 186-191
-
-
Deschenes, I.1
Finkle, C.D.2
Winocour, P.D.3
-
41
-
-
0031987937
-
Vascular cell-derived fibrinolytic regulators and atherothrombotic vascular disorders
-
Shen GX: Vascular cell-derived fibrinolytic regulators and atherothrombotic vascular disorders. Int J Mol Med 1, 399-408 (1998)
-
(1998)
Int J Mol Med
, vol.1
, pp. 399-408
-
-
Shen, G.X.1
-
42
-
-
0037630699
-
Hirulog-like peptide reduces restenosis and expression of tissue factor and transforming growth factor-beta in carotid artery of atherosclerotic rabbits
-
Chen X, S. Ren, M.G. Ma, S. Dharmalingam, L. Lu, M. Xue, J. Ducas & G.X. Shen. Hirulog-like peptide reduces restenosis and expression of tissue factor and transforming growth factor-beta in carotid artery of atherosclerotic rabbits. Atherosclerosis 169, 31-40 (2003)
-
(2003)
Atherosclerosis
, vol.169
, pp. 31-40
-
-
Chen, X.1
Ren, S.2
Ma, M.G.3
Dharmalingam, S.4
Lu, L.5
Xue, M.6
Ducas, J.7
Shen, G.X.8
-
43
-
-
0019891328
-
Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion
-
Okamoto S, A. Hijikata, R. Kikumoto, S. Tonomura, H. Hara, K. Ninomiya, A. Maruyama, M. Sugano & Y. Tamao: Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion. Biochem Biophys Res Commun 101, 440-446 (1981)
-
(1981)
Biochem Biophys Res Commun
, vol.101
, pp. 440-446
-
-
Okamoto, S.1
Hijikata, A.2
Kikumoto, R.3
Tonomura, S.4
Hara, H.5
Ninomiya, K.6
Maruyama, A.7
Sugano, M.8
Tamao, Y.9
-
44
-
-
0034091906
-
Clinical application of argatroban as an alternative anticoagulant for extracorporeal circulation
-
Kawada T, H. Kitagawa, M. Hoson, Y. Okada & J. Shiomura: Clinical application of argatroban as an alternative anticoagulant for extracorporeal circulation, Hematol Oncol Clin North Am 14, 445-457 (2000)
-
(2000)
Hematol Oncol Clin North Am
, vol.14
, pp. 445-457
-
-
Kawada, T.1
Kitagawa, H.2
Hoson, M.3
Okada, Y.4
Shiomura, J.5
-
45
-
-
2942665487
-
Small-molecule direct antithrombins: Argatroban
-
Fareed J & W.P. Jeske: Small-molecule direct antithrombins: argatroban. Best Pract Res Clin Haematol 17, 127-138 (2004)
-
(2004)
Best Pract Res Clin Haematol
, vol.17
, pp. 127-138
-
-
Fareed, J.1
Jeske, W.P.2
-
46
-
-
0029065197
-
Comparative studies on the anticoagulant and protease generation inhibitory actions of newly developed site-directed thrombin inhibitory drugs. Efegatran, argatroban, hirulog, and hirudin
-
Callas DD, D. Hoppensteadt & J. Fareed: Comparative studies on the anticoagulant and protease generation inhibitory actions of newly developed site-directed thrombin inhibitory drugs. Efegatran, argatroban, hirulog, and hirudin. Semin Thromb Hemost 21, 177-183 (1995)
-
(1995)
Semin Thromb Hemost
, vol.21
, pp. 177-183
-
-
Callas, D.D.1
Hoppensteadt, D.2
Fareed, J.3
-
47
-
-
0025328906
-
Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a tree tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H
-
Bajusz S, E. Szell, D. Bagdy, E. Barabas, G. Horvath, M. Dioszegi, Z. Fittler, G. Szabo, A. Juhasz, E. Tomori & et al: Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a tree tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H. J Med Chem 33, 1729-1735 (1990)
-
(1990)
J Med Chem
, vol.33
, pp. 1729-1735
-
-
Bajusz, S.1
Szell, E.2
Bagdy, D.3
Barabas, E.4
Horvath, G.5
Dioszegi, M.6
Fittler, Z.7
Szabo, G.8
Juhasz, A.9
Tomori, E.10
-
48
-
-
0028860447
-
Aspirin does not potentiate effect of suboptimal dose of the thrombin inhibitor inogatran during coronary thrombolysis
-
Chen LY, W. W. Nichols, C. Mattsson, A. C. Teger-Nilson, R. Wallin, T. G. Saldeen & J. L. Mehta: Aspirin does not potentiate effect of suboptimal dose of the thrombin inhibitor inogatran during coronary thrombolysis. Cardiovasc Res 30, 866-874 (1995)
-
(1995)
Cardiovasc Res
, vol.30
, pp. 866-874
-
-
Chen, L.Y.1
Nichols, W.W.2
Mattsson, C.3
Teger-Nilson, A.C.4
Wallin, R.5
Saldeen, T.G.6
Mehta, J.L.7
-
49
-
-
0030932442
-
In vitro effects of inogatran, a selective low molecular weight thrombin inhibitor
-
Teger-Nilsson AC, R. Bylund, D. Gustafsson, E. Gyzander & U. Eriksson: In vitro effects of inogatran, a selective low molecular weight thrombin inhibitor. Thromb Res 85, 133-145 (1997)
-
(1997)
Thromb Res
, vol.85
, pp. 133-145
-
-
Teger-Nilsson, A.C.1
Bylund, R.2
Gustafsson, D.3
Gyzander, E.4
Eriksson, U.5
-
50
-
-
0032522549
-
Heparin is more effective than inogatran, a low-molecular weight thrombin inhibitor in suppressing ischemia and recurrent angina in unstable coronary disease
-
Thrombin Inhibition in Myocardial Ischemia (TRIM) Study Group
-
Andersen K & M. Dellborg: Heparin is more effective than inogatran, a low-molecular weight thrombin inhibitor in suppressing ischemia and recurrent angina in unstable coronary disease. Thrombin Inhibition in Myocardial Ischemia (TRIM) Study Group. Am J Cardiol 81, 939-944 (1998)
-
(1998)
Am J Cardiol
, vol.81
, pp. 939-944
-
-
Andersen, K.1
Dellborg, M.2
-
51
-
-
0030946942
-
Molecular determinants of recognition for the intestinal peptide carrier
-
Swaan PW & J. J. Tukker: Molecular determinants of recognition for the intestinal peptide carrier. J Pharm Sci 86, 596-602 (1997)
-
(1997)
J Pharm Sci
, vol.86
, pp. 596-602
-
-
Swaan, P.W.1
Tukker, J.J.2
-
52
-
-
0031952430
-
Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery
-
Mehta JL, L. Chen, W. W. Nichols, C. Mattsson, D. Gustafsson & T. G. Saldeen: Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol 31, 345-351 (1998)
-
(1998)
J Cardiovasc Pharmacol
, vol.31
, pp. 345-351
-
-
Mehta, J.L.1
Chen, L.2
Nichols, W.W.3
Mattsson, C.4
Gustafsson, D.5
Saldeen, T.G.6
-
53
-
-
0037033169
-
Molecular design and structure-activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664
-
Das J, S.D. Kimball, S.E. Hall, W.C. Han, E. Iwanowicz, J. Lin, R.V. Moquin, I.A. Reid, J.S. Sack, M.F. Malley, C.Y. Chang, S. Chong, D.B. Wang-Iverson, D.G. Roberts, S.M. Seiler, W.A. Schumacher & M.L. Ogletree: Molecular design and structure-activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. Bioorg Med Chem Lett 12, 45-49 (2002)
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 45-49
-
-
Das, J.1
Kimball, S.D.2
Hall, S.E.3
Han, W.C.4
Iwanowicz, E.5
Lin, J.6
Moquin, R.V.7
Reid, I.A.8
Sack, J.S.9
Malley, M.F.10
Chang, C.Y.11
Chong, S.12
Wang-Iverson, D.B.13
Roberts, D.G.14
Seiler, S.M.15
Schumacher, W.A.16
Ogletree, M.L.17
-
54
-
-
0023920918
-
Experimental oral anticoagulation by a directly acting thrombin inhibitor (RGH-2958)
-
Bagdy D, E. Barabas, Z. Fittler, E. Orban, G. Rabloczky, S. Bajusz & E. Szell: Experimental oral anticoagulation by a directly acting thrombin inhibitor (RGH-2958) Folia Haematol Int Mag Klin Morphol Blutforsch 115, 136-140 (1988)
-
(1988)
Folia Haematol Int Mag Klin Morphol Blutforsch
, vol.115
, pp. 136-140
-
-
Bagdy, D.1
Barabas, E.2
Fittler, Z.3
Orban, E.4
Rabloczky, G.5
Bajusz, S.6
Szell, E.7
-
55
-
-
0027991615
-
Analysis of the thrombin inhibitor DuP 714 by an enzyme-linked immunosorbent assay
-
Mitchell TJ, R. M. Knabb, D. D. Christ, A. R. Farmer & T. M. Reilly: Analysis of the thrombin inhibitor DuP 714 by an enzyme-linked immunosorbent assay. Blood Coagul Fibrinolysis 5, 517-521 (1994)
-
(1994)
Blood Coagul Fibrinolysis
, vol.5
, pp. 517-521
-
-
Mitchell, T.J.1
Knabb, R.M.2
Christ, D.D.3
Farmer, A.R.4
Reilly, T.M.5
-
56
-
-
0033678017
-
Successful attenuation of venous thrombus growth in rabbits after the administration of a novel oral thrombin inhibitor
-
Friederich PW, T. T. Keller, B. J. Biemond, R. J. Peters, W. Hornberger, H. R. Buller & M. Levi: Successful attenuation of venous thrombus growth in rabbits after the administration of a novel oral thrombin inhibitor. Thromb Haemost 84, 858-864 (2000)
-
(2000)
Thromb Haemost
, vol.84
, pp. 858-864
-
-
Friederich, P.W.1
Keller, T.T.2
Biemond, B.J.3
Peters, R.J.4
Hornberger, W.5
Buller, H.R.6
Levi, M.7
-
57
-
-
0034526532
-
The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis
-
McClanahan TB, G. W. Hicks, D. P. Ignasiak, R. Bousley, T. E. Mertz, P. Juneau, N. Janiczek-Dolphin, I. C. Kim & K. P. Gallagher: The Antithrombotic Effects of CI-1028, an Orally Bioavailable Direct Thrombin Inhibitor, in a Canine Model of Venous and Arterial Thrombosis. J Thromb Thrombolysis 10, 277-284 (2000)
-
(2000)
J Thromb Thrombolysis
, vol.10
, pp. 277-284
-
-
McClanahan, T.B.1
Hicks, G.W.2
Ignasiak, D.P.3
Bousley, R.4
Mertz, T.E.5
Juneau, P.6
Janiczek-Dolphin, N.7
Kim, I.C.8
Gallagher, K.P.9
-
58
-
-
0033526016
-
Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors
-
Dominguez C, D.E. Duffy, Q. Han, R.S. Alexander, R.A. Galemmo Jr, J.M. Park, P.C. Wong, E.C. Amparo, R.M. Knabb, J. Luettgen, R.R. Wexler: Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors. Bioorg Med Chem Lett 9, 925-930 (1999)
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 925-930
-
-
Dominguez, C.1
Duffy, D.E.2
Han, Q.3
Alexander, R.S.4
Galemmo Jr., R.A.5
Park, J.M.6
Wong, P.C.7
Amparo, E.C.8
Knabb, R.M.9
Luettgen, J.10
Wexler, R.R.11
-
59
-
-
0032892945
-
Antithrombotic efficacy of thrombin inhibitor L-374,087: Intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis
-
Cook JJ, S. J. Gardell, M. A. Holahan, G. R. Sitko, G. L. Stump, A. A. Wallace, D. B. Gilberto, T. R. Hare, J. A. Krueger, D. L. Dyer, P. E. Sanderson, J. P. Vacca, J. A. Shafer & J. J. Lynch Jr: Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis. J Pharmacol Exp Ther 289, 503-510 (1999)
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 503-510
-
-
Cook, J.J.1
Gardell, S.J.2
Holahan, M.A.3
Sitko, G.R.4
Stump, G.L.5
Wallace, A.A.6
Gilberto, D.B.7
Hare, T.R.8
Krueger, J.A.9
Dyer, D.L.10
Sanderson, P.E.11
Vacca, J.P.12
Shafer, J.A.13
Lynch Jr., J.J.14
-
60
-
-
0026575221
-
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
-
Bock LC, L. C. Griffin, J. A. Latham, E. H. Vermaas & J. J. Toole: Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature 355, 564-566 (1992)
-
(1992)
Nature
, vol.355
, pp. 564-566
-
-
Bock, L.C.1
Griffin, L.C.2
Latham, J.A.3
Vermaas, E.H.4
Toole, J.J.5
-
61
-
-
0028136665
-
The application of a modified nucleotide in aptamer selection: Novel thrombin aptamers containing 5-(1-pentynyl)-2′-deoxyuridine
-
Latham JA, R. Johnson, & J. J. Toole: The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing 5-(1-pentynyl)-2′-deoxyuridine. Nucleic Acids Res 22, 2817-2822 (1994)
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 2817-2822
-
-
Latham, J.A.1
Johnson, R.2
Toole, J.J.3
-
62
-
-
0028097736
-
A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formation
-
Li WA, A. V. Kaplan, G. W. Grant, J. J. Toole & L. L. Leung: A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formation. Blood 83, 677-682 (1994)
-
(1994)
Blood
, vol.83
, pp. 677-682
-
-
Li, W.A.1
Kaplan, A.V.2
Grant, G.W.3
Toole, J.J.4
Leung, L.L.5
-
63
-
-
0029915374
-
Prevention of deep-vein thrombosis after total hip replacement: Direct thrombin inhibition with recombinant hirudin, CGP 39393
-
Eriksson BI, S. Ekman, P. Kalebo, B. Zachrisson, D. Bach & P. Close: Prevention of deep-vein thrombosis after total hip replacement: direct thrombin inhibition with recombinant hirudin, CGP 39393. Lancet 347, 635-639 (1996)
-
(1996)
Lancet
, vol.347
, pp. 635-639
-
-
Eriksson, B.I.1
Ekman, S.2
Kalebo, P.3
Zachrisson, B.4
Bach, D.5
Close, P.6
-
64
-
-
0027985641
-
Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery
-
Ginsberg JS, M. T. Nurmohamed, M. Gent, B. MacKinnon, J. Sicurella, P. Brill-Edwards, M. N. Levine, A. A. Panju, P. Powers, P. Stevens & et al. Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery. Circulation 90, 2385-2389 (1994)
-
(1994)
Circulation
, vol.90
, pp. 2385-2389
-
-
Ginsberg, J.S.1
Nurmohamed, M.T.2
Gent, M.3
MacKinnon, B.4
Sicurella, J.5
Brill-Edwards, P.6
Levine, M.N.7
Panju, A.A.8
Powers, P.9
Stevens, P.10
-
65
-
-
0032958887
-
Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: Experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion
-
Kleiman NS, C. B. Granger, H. D. White, P. Armstrong, D. Ardissino, F. V. de Werf, P. Zoldeyhi, T. D. Thompson, R. M. Califf & E. J. Topol: Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion. Am Heart J 137, 12-23 (1999)
-
(1999)
Am Heart J
, vol.137
, pp. 12-23
-
-
Kleiman, N.S.1
Granger, C.B.2
White, H.D.3
Armstrong, P.4
Ardissino, D.5
De Werf, F.V.6
Zoldeyhi, P.7
Thompson, T.D.8
Califf, R.M.9
Topol, E.J.10
-
66
-
-
0033574099
-
FDA panel votes against approval for bivalirudin
-
Pina I: FDA panel votes against approval for bivalirudin. Circulation 99, 1277 (1999)
-
(1999)
Circulation
, vol.99
, pp. 1277
-
-
Pina, I.1
-
67
-
-
0027987849
-
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
-
The Scandinavian Simvastatin Survival Study Group: Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet 344, 1383-1389 (1994)
-
(1994)
Lancet
, vol.344
, pp. 1383-1389
-
-
-
68
-
-
0342981862
-
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
-
Cholesterol and Recurrent Events Trial investigators
-
Sacks FM, M.A. Pfeffer, L.A. Moye, J.L. Rouleau, J.D. Rutherford, T.G. Cole, L. Brown, J.W. Warnica, J.M. Arnold, C.C. Wun, B.R. Davis & E. Braunwald: The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 335, 1001-1009 (1996)
-
(1996)
N Engl J Med
, vol.335
, pp. 1001-1009
-
-
Sacks, F.M.1
Pfeffer, M.A.2
Moye, L.A.3
Rouleau, J.L.4
Rutherford, J.D.5
Cole, T.G.6
Brown, L.7
Warnica, J.W.8
Arnold, J.M.9
Wun, C.C.10
Davis, B.R.11
Braunwald, E.12
-
69
-
-
0032487931
-
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
-
The Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group: Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 339, 1349-1357 (1998)
-
(1998)
N Engl J Med
, vol.339
, pp. 1349-1357
-
-
-
70
-
-
0036156342
-
The MRC/BHF Heart Protection Study: Preliminary results
-
Collins R, R. Peto, J. Armitage: The MRC/BHF Heart Protection Study: preliminary results. Int J Clin Pract 56, 53-56 (2002)
-
(2002)
Int J Clin Pract
, vol.56
, pp. 53-56
-
-
Collins, R.1
Peto, R.2
Armitage, J.3
-
71
-
-
0037840242
-
MRC/BHF Heart Protection Study of cholesterol-lowering with Simvastatin in 5963 people with diabetes: A randomized placebo-controlled trial
-
Collins R, J. Armitage, S. Parish, P. Sleigh, R. Peto: Heart Protection study Collaborative Group:MRC/BHF Heart Protection Study of cholesterol-lowering with Simvastatin in 5963 people with diabetes: a randomized placebo-controlled trial. Lancet 361, 2005-2016 (2003)
-
(2003)
Lancet
, vol.361
, pp. 2005-2016
-
-
Collins, R.1
Armitage, J.2
Parish, S.3
Sleigh, P.4
Peto, R.5
-
72
-
-
18444400587
-
Statins: Effects beyond cholesterol lowering. Guest Editor's comments
-
Shen GX: Statins: Effects beyond cholesterol lowering. Guest Editor's comments. Cur Drug Target: Cardiovasc Haematol Disord 5:111-113 (2005)
-
(2005)
Cur Drug Target: Cardiovasc Haematol Disord
, vol.5
, pp. 111-113
-
-
Shen, G.X.1
-
73
-
-
0031586447
-
Simvastatin reduces monocyte-tissue-factor expression type IIa hypercholesterolaemia
-
Ferro D, S. Basili, C. Alessandri, B. Mantovani, C. Cordova, F. Violi: Simvastatin reduces monocyte-tissue-factor expression type IIa hypercholesterolaemia. Lancet 350, 1222 (1997)
-
(1997)
Lancet
, vol.350
, pp. 1222
-
-
Ferro, D.1
Basili, S.2
Alessandri, C.3
Mantovani, B.4
Cordova, C.5
Violi, F.6
-
74
-
-
0033373592
-
Statins as cellular antithrombotics
-
Fenton II JW & G.X. Shen: Statins as cellular antithrombotics. Haemostasis 29, 166-169 (1999)
-
(1999)
Haemostasis
, vol.29
, pp. 166-169
-
-
Fenton II, J.W.1
Shen, G.X.2
-
75
-
-
25444495637
-
Impact of Simvastatin on hemostatic and fibrinolytic regulators in type 2 diabetic mellitus
-
Epub. April 29
-
Ludwig S, S. Dharmalingam, S. Erickson-Nesmith, S. Ren, F. Zhu, G. M. Ma, R. Zhao, J. W. Fenton II, F. A. Ofosu, H. te Velthuis, G. van Mierlo & G. X. Shen: Impact of Simvastatin on hemostatic and fibrinolytic regulators in type 2 diabetic mellitus. Diabetes Res Clin Prac Epub. April 29 (2005)
-
(2005)
Diabetes Res Clin Prac
-
-
Ludwig, S.1
Dharmalingam, S.2
Erickson-Nesmith, S.3
Ren, S.4
Zhu, F.5
Ma, G.M.6
Zhao, R.7
Fenton II, J.W.8
Ofosu, F.A.9
Te Velthuis, H.10
Van Mierlo, G.11
Shen, G.X.12
-
76
-
-
17044448335
-
Mechanisms of action of statins and their pleiotropic effects
-
Davignon J & L. Mabile: Mechanisms of action of statins and their pleiotropic effects. Ann Endocrinol 62, 101-112 (2001)
-
(2001)
Ann Endocrinol
, vol.62
, pp. 101-112
-
-
Davignon, J.1
Mabile, L.2
-
77
-
-
0037117639
-
Statin prevents tissue factor expression in human endothelial cells: Role of Rho/Rho-kinase and Akt pathways
-
Eto M, T. Kozai, F. Cosentino, H. Joch & T.F. Luscher: Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways. Circulation 105, 1756-1759 (2002)
-
(2002)
Circulation
, vol.105
, pp. 1756-1759
-
-
Eto, M.1
Kozai, T.2
Cosentino, F.3
Joch, H.4
Luscher, T.F.5
-
78
-
-
0041735202
-
A safety look at currently available statins
-
Moghadasian MH: A safety look at currently available statins. Expert Opin Drug Saf 1, 269-274 (2002)
-
(2002)
Expert Opin Drug Saf
, vol.1
, pp. 269-274
-
-
Moghadasian, M.H.1
|