Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 7, 1999, Pages 925-930

  Dominguez, Celia ^a,b   Duffy, Daniel E ^a   Han, Qi ^a   Alexander, Richard S ^a   Galemmo Jr , Robert A ^a   Park, Jeongsook M ^a   Wong, Pancras C ^a   Amparo, Eugene C ^a   Knabb, Robert M ^a   Luettgen, Joseph ^a   Wexler, Ruth R ^a  

^a DUPONT COMPANY   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMIDINOINDOLE DERIVATIVE; SERINE PROTEINASE; THROMBIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG; XU 817;

ANTICOAGULATION; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CATALYSIS; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; LIPOPHILICITY; THROMBOEMBOLISM; THROMBOSIS;

AMIDINES; ANIMALS; ANTITHROMBINS; DRUG DESIGN; HETEROCYCLIC COMPOUNDS; HYDROGEN BONDING; INDOLES; MOLECULAR STRUCTURE; RATS;

EID: 0033526016     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00113-4     Document Type: Article

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