Intellectual decline in schizophrenia: Evidence from a prospective birth cohort 28 year follow-up study

Journal of Clinical and Experimental Neuropsychology

Volumn 28, Issue 2, 2006, Pages 225-242

  Seidman, Larry J ^a,b,c,h   Buka, Stephen L ^c,d   Goldstein, Jill M ^a,b,c,e,f   Tsuang, Ming T ^a,b,c,d,g  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e Division of Women's Health   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Deterioration; High Risk; IQ; Schizophrenia

Indexed keywords

ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FOLLOW UP; HIGH RISK BEHAVIOR; HUMAN; INTELLECTUAL IMPAIRMENT; INTELLIGENCE QUOTIENT; LONGITUDINAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOSIS; SCHIZOPHRENIA; SCHOOL CHILD; WECHSLER INTELLIGENCE SCALE;

ACHIEVEMENT; ADULT; AGE FACTORS; CHILD; COGNITION DISORDERS; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; SCHIZOPHRENIA; SEVERITY OF ILLNESS INDEX;

EID: 32844457063     PISSN: 13803395     EISSN: None     Source Type: Journal    
DOI: 10.1080/13803390500360471     Document Type: Article

References (75)

1. American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders DSM-III-R (3rd edition revised). Washington, D. C.: American Psychiatric Association.
2. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders: DSM-FV (4th edition). Washington, D. C.: American Psychiatric Association.
3. Aylward, E., Walker, E., & Bettes, B. (1984). Intelligence in schizophrenia: Meta-analysis of the research. Schizophr Bull, 10, 430-459.
4. Bilder, R. M., Lipschutz-Broch, L., Reiter, G., Geisler, S. H., Mayerhoff, D. I., & Lieberman, J. A. (1992). Intellectual deficits in first-episode schizophrenia: Evidence for progressive deterioration. Schizophr Bull, 18, 437-448.
5. Bleuler, E. (1950). Dementia Praecox or The Group of Schizophrenias. New York, NY: International Universities Press, Inc.
6. Broman, S., Bien, E., & Shaughnessy, P. (1985). Low achieving children: The first seven years. Hillsdake, NJ: Lawrence Erlbaum Associates.
7. Broman, S. H., Nichols, P. I., & Kennedy, W. A. (1975). Preschool IQ: Prenatal and early developmental correlates. New York: Halsted Press.
8. Brooker, B. H., & Cyr, J. J. (1986). Tables for clinicians to use to convert WAIS-R short forms. J Clin Psychol, 42, 983-986.
9. Brown, S. J., Rourke, B. P., & Cicchetti, D. (1989). Reliability of tests and measures used in the neuropsychological assessment of children. Clin Neuropsychol, 3, 353-368.
10. Buka, S. L., Goldstein, J. M., Seidman, L. J., Zornberg, G. L., Donatelli, J. A., & Denny, L. et al. (1999). Prenatal complications, genetic vulnerability, and schizophrenia: The New England longitudinal studies of schizophrenia. Psychiatric Annals, 29, 151-156.
11. Buka, S. L., Satz, P., Seidman, L. J., & Lipsitt, L. (1998). Defining learning disabilities: The role of longitudinal studies. Thalamus, 16, 14-29.
12. Buka, S. L., Tsuang, M. T., & Lipsitt, L. P. (1993). Pregnancy/delivery complications and psychiatric diagnosis: A prospective study. Arch Gen Psychiatry, 50, 151-156.
13. Cannon, T. D., Rosso, I. M., Hollister, J. M., Bearden, C. E., Sanchez, L. E., & Hadley, T. (2000). A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. Schizophr Bull, 26, 351-66.
14. Chen, E. Y., Lam, L. C., Chen, R. Y., Nguyen, D. G., & Chan, C. K. (1996). Prefrontal neuropsychological impairment and illness duration in schizophrenia: A study of 204 patients in Hong Kong. Acta Psychiatr Scand, 93, 144-150.
15. Cornblatt, B., Obuchowski, M., Roberts, S., Pollack, S., & Erlenmeyer-Kimling, L. (1999). Cognitive and behavioral precursors of schizophrenia. Dev Psychopathol, 11, 487-508.
16. Cosway, R, Byrne, M., Clafferty, R., Hodges, A., Grant, E., & Abukmeil, S. S. et al. (2000). Neuropsychological change in young people at high risk for schizophrenia: Results from the first two neuropsychological assessments of the Edinburgh High Risk Study. Psychol Med, 30, 1111-1121.
17. Davidson, M., Harvey, P. D., Powchik, P., Parrella, M., White, L., & Knobler, H. Y. et al. (1995). Severity of symptoms in chronically institutionalized geriatric schizophrenic patients. Am J Psychiatry, 152, 197-207.
18. Davidson, M., Reichenberg, A., Rabinowitz, J., Weiser, M., Kaplan, Z., & Mark, M. (1999). Behavioral and intellectual markers for schizophrenia in apparently healthy adolescents. Am J Psychiatry, 156, 1328-1335.
19. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. (1996). Structured clinical interview for DSM-IV axis disorders. Patient Edition (SCID-I/P), Version 2. Washington, D.C.: American Psychiatric Press.
20. Fish, B., Shapiro, T., Halpern, F., & Wile, R. (1965). The prediction of schizophrenia in infancy: III. A ten-year follow-up report of neurological and psychological development. Am J Psychiatry, 121, 768-775.
21. Fish, B., Marcus, J., Hans, S. L., Auerbach, J. G., & Perdue, S. (1992). Infants at risk for schizophrenia: Sequelae of a genetic neurointegrative defect. A review and replication analysis of pandys-maturation in the Jerusalem infant development study. Arch Gen Psychiatry, 49, 221-235.
22. Fucetola, R., Seidman, L. J., Kremen, W.S., Faraone, S. V., Goldstein, J. M., & Tsuang, M. T. (2000). Age and neuropsychological function in schizophrenia: A decline in executive functions compared to normal volunteers. Biol Psychiatry, 48, 137-146.
23. Goldberg, E., & Seidman, L. J. (1991). Higher cortical functions in normals and in schizophrenia: A selective review. In S. Steinhauer, J. Gruzelier, & J. Zubin (Eds.), Handbook of Schizophrenia (Vol. 5). Neuropsychology, psychophysiology and information processing (pp. 553-597). New York: Elsevier.
24. Goldberg, T. E., Hyde, T. M., Kleinman, J. E., & Weinberger, D. R. (1993). Course of schizophrenia: Neuropsychological evidence for a static encephalopathy. Schizophr Bull, 19, 797-804.
25. Goldberg, T. E., Torrey, E. F., Gold, J. M., Bigelow, L. B., Ragland, R. D., & Taylor, E. et al. (1995). Genetic risk of neuropsychological impairment in schizophrenia: A study of monozygotic twin discordant and concordant for the disorder. Schizophr Res, 17, 77-84.
26. Goldstein, J. M., Seidman, L. J., Buka, S. L., Horton, N. J., Donatelli, J. L., & Rieder, R. O. et al. (2000). Impact of genetic vulnerability and hypoxia on overall intelligence by age 7 in offspring at high risk for schizophrenia compared with affective psychoses. Schizophr Bull, 26, 323-334.
27. Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry, 153, 321-330.
28. Hamlin, R. M., & Ward, W. D. (1973). Schizophrenic intelligence, symptoms and release from the hospital. J Abnorm Psychol, 81, 11-16.
29. Harvey, P. D., Docherty, N. M., Serper, M. R., & Rasmussen, M. (1990). Cognitive deficits and thought disorder: II. An eight month follow-up study. Schizophr Bull, 16, 147-156.
30. Harvey, P. D., Silverman, J. M., Mohs, R. C., Parrella, M., White, L., & Powchik, P. et al. (1999). Cognitive decline in late-life schizophrenia: A longitudinal study of geriatric chronically hospitalized patients. Biol Psychiatry, 45, 32-40.
31. Harvey, P. D., White, L., Parrella, M., Putnam, K. M., Kincaid, M. M., & Powchik, P. et al. (1995). The longitudinal stability of cognitive impairment in schizophrenia: Mini-Mental State scores at one- and two-year follow-ups in geriatric inpatients. Br J Psychiatry, 166, 630-633.
32. Heaton, R. K., & Drexler, M. (1987). Clinical neuropsychological findings in schizophrenia and aging. In N. E. Miller, & G. D. Cohen (Eds.), Schizophrenia and Aging: Schizophrenia, paranoia, and schizophreniform disorders in later life. New York: Guilford.
33. Heaton, R., Paulsen, J. S., McAdams, L. A., & Kuck, J. et al. (1994). Neuropsychological deficits in schizophrenics: Relationship to age, chronicity and dementia. Arch Gen Psychiatry, 51, 469-476.
34. Hyde, T. M., Nawroz, S., Goldberg, T. E., Bigelow, L. B., Strong, D., & Ostrem, J. L. et al. (1994). Is there cognitive decline in schizophrenia: A cross-sectional study. Br J Psychiatry, 164, 494-500.
35. Jastak, J. F., & Jastak, S (1965). The Wide Range Achievement Test. Wilmington, Delaware: Jastak Associates.
36. Jones, P., Rodgers, B., Murray, R. M., & Marmot, M. (1994). Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet, 344, 1398-1402.
37. Keefe, R. S. E., Seidman, L. J., Christensen, B. K., Hamer, R. M., Sharma, T., & Sitskoorn, M. M. et al. (2004). Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: A randomized, double-blind trial of olanzapine versus low doses of haloperidol. Am J Psychiatry, 161, 985-995.
38. Klonoff, H., Fibiger, C. H., & Hutton, G. H. (1970). Neuropsychological patterns in chronic schizophrenia. J Nerv Ment Dis, 150, 291-300.
39. Kondel, T. K., Mortimer, A. M., Leeson, V. C., Laws, K. R., & Hirsch, S. R. (2003). Intellectual differences between schizophrenic patients and normal controls across the adult lifespan. J Clin Exp Neuropsychol, 25, 1045-1056.
40. Koren, D., Seidman, L. J., Harrison, R. H., Lyons, M. J., Kremen, W. S., & Caplan, B. B. et al. (1998). Factor structure of the Wisconsin Card Sorting Test: Dimensions of deficit in schizophrenia. Neuropsychology, 12, 289-302.
41. Kraepelin, E. (1919). Dementia Praecox and Paraphrenia. Edinburgh: E & S Livingstone.
42. Kremen, W. S., Buka, S. L., Seidman, L. J., Goldstein, J. M., Koren, D., & Tsuang, M. T. (1998). IQ decline during childhood and adult psychotic symptoms in a community sample: A 19-year longitudinal study. Am J Psychiatry, 155, 672-679.
43. Kremen, W. S., Seidman, L. J., Faraone, S. V., & Tsuang, M. T. (2001). IQ and neuropsychological profiles in patients with schizophrenia and normal volunteers. Biol Psychiatry, 50, 453-462.
44. Margolis, R. B., Taylor, J. M., & Greenlief, C. L. (1986). A cross-validation of two short forms of the WAIS-R in a geriatric sample suspected dementia. J Clin Psychol, 42, 145-146.
45. Maxwell, M. E. (1996). Family interview for genetic studies. Clinical Neurogenetics Branch: Intramural Research Program. NIMH.
46. Mednick, S. A., Parnas, J., & Schulsinger, F. (1987). The Copenhagen High-Risk Project, 1962-86. Schizophr Bull, 13, 485-95.
47. Moberg, P. J., Doty, R. L., Turetsky, B. I., Arnold, S. E., Mahr, R. N., & Gur, R. C. et al. (1997). Olfactory identification deficits in schizophrenia: Correlation with duration of illness. Am J Psychiatry, 154, 1016-1018.
48. Mockler, D., Riordan, J., & Sharma, T. (1997). Memory and intellectual deficits do not decline with age in schizophrenia. Schizophr Res, 26, 1-7.
49. Murray, R. M., & Lewis, S. W. (1987). Is schizophrenia a neurodevelopmental disorder? Br Med J, 295, 681-682.
50. Myrianthopoulos, N. C., & French, K. S. (1968). An application of the U.S. Bureau of the Census socioeconomic index to a large, diversified patient population. Soc Sci Med, 2, 283-299.
51. Nichols, P. L., & Chen, T. C. (1981). Minimal brain dysfunction: A prospective study. Hillsdale, NJ: Lawrence Erlbaum Associates.
52. Niendam, T. A., Bearden, C. E., Rosso, I. M., Sanchez, L. E., Hadley, T., & Nuechterlein, K. H. et al. (2003). A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am J Psychiatry, 160, 2060-2062.
53. Niswander, K. R., & Gordon, M. (1972). The women and their pregnancies. Washington, D.C.: U.S. Government Printing Office.
54. Olin, S. S., & Mednick, S.A. (1996). Risk factors of psychosis: Identifying vulnerable populations premorbidly. Schizophr Bull, 22, 223-240.
55. Payne, R. W. (1960). Cognitive abnormalities. In H. J. Eysenck (Ed.), Handbook of abnormal psychology (pp. 420-483). London, England: Pitman Medical.
56. Robins, L. N., Helzer, J. E., Croughan, J., & Ratcliff, K. S. (1981). National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. Arch Gen Psychiatry, 38, 381-389.
57. Roth, D. L., Hughes, C. W., Monkowski, P. G., & Crosson, B. (1984). Investigation of the validity of WAIS-R short forms for patients suspected to have brain impairment. J Consult Clin Psychol, 52, 722-723.
58. Rund, B. R. (1998). A review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophr Bull, 24, 425-435.
59. Russell, A. J., Munro, J. C., Jones, P. B., Hemsley, D. R., & Murray, R. M. (1997). Schizophrenia and the myth of intellectual decline. Am J Psychiatry, 154, 635-639.
60. Ryan, J. J., Larsen, J., & Prifitera, A. (1983). Validity of two and four subtest short forms of the WAIS-R in a psychiatric sample. J Consul Clin Psychol, 51, 460.
61. Seidman, L. J. (1983). Schizophrenia and brain dysfunction: An integration of recent neurodiagnostic findings. Psychol Bull, 94, 195-238.
62. Seidman, L. J. (1990). The neuropsychology of schizophrenia: A neurodevelopmental and case study approach. J Neuropsychiatiy Clin Neurosci, 2, 301-312.
63. Seidman, L. J., Buka, S. L., Goldstein, J. M., Horton, N., Rieder, R. O., & Donatelli, J. et al. (2000). The relationship of obstetrical complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal Project. Schizophr Bull, 26, 309-321.
64. Seidman, L. J., Cassens, G., Kremen, W. S., & Pepple, J. R. (1992). The neuropsychology of schizophrenia. In R. White (Ed.), Clinical syndromes in adult neuropsychology: The practioner's handbook (pp. 381-449). Amsterdam: Elsevier.
65. Sheitman, B. B., Murray, M. G., Snyder, J. A., Silva, S., Goldman, R., & Chakos, M. et al. (2000). IQ scores of treatment resistant schizophrenia patients before and after the onset of the illness. Schizophr Res, 46, 203-207.
66. Smith, A. (1964). Mental deterioration in chronic schizophrenia. J Ment Nerv Dis, 139, 479-487.
67. Stone, W. S., Faraone, S. V., Seidman, L. J., Olson, E. A., & Tsuang, M. T. (2005). Searching for the liability to schizophrenia: Concepts and methods underlying genetic high risk studies of adolescents. J Child Adolescent Psychopharmacology, 15, 403-417.
68. Sullivan, E. V., Shear, P. K., Zipursky, R. B., Sagar, H. J., & Pfefferbaum, A. (1994). A deficit profile of executive, memory, and motor functions in schizophrenia. Biol Psychiatry, 36, 641-653.
69. Sweeney, J. A., Haas, G. L., Keilp, J. G., & Long, M. (1991). Evaluation of the stability of neuropsychological functioning after acute episodes of schizophrenia: A one-year follow-up study. Psychiatry Res, 38, 63-76.
70. Thompson, A. P., Howard, D., & Anderson, J. (1986). Two and four subtest short forms of the WAIS-R: Validity in a psychiatric sample. Can J Behavioral Science, 18, 287-293.
71. Waddington, J. L., Youssef, H. A., & Kinsella, A. (1990). Cognitive dysfunction in schizophrenia followed up over 5 years, and its longitudinal relationship to the emergence of tardive dyskinesia. Psychol Med, 20, 835-842.
72. Wechsler, D. (1949). The Wechsler Intelligence Scale for Children. New York, NY: The Psychological Corporation.
73. Wechsler, D. (1981). Manual for the Wechsler Adult Intelligence Scale-revised. San Antonio, TX: Psychological Corporation.
74. Weinberger, D.R. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry, 44, 660-690.
75. Woods, B. T. (1998). Is schizophrenia a progressive neurodevelopmental disorder? Towards a unitary pathogenetic mechanism. Am J Psychiatry, 155, 1661-1670.